The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system.
Saha I, Yuste-Checa P, Da Silva Padilha M, Guo Q, Korner R, Holthusen H, Trinkaus VA, Dudanova I, Fernandez-Busnadiego R, Baumeister W, Sanders DW, Gautam S, Diamond MI, Hartl FU, Hipp MS
Nat Commun. 2023 Feb 2;14(1):560. doi: 10.1038/s41467-023-36058-2. PubMed Article
Saha I, Yuste-Checa P, Da Silva Padilha M, Guo Q, Korner R, Holthusen H, Trinkaus VA, Dudanova I, Fernandez-Busnadiego R, Baumeister W, Sanders DW, Gautam S, Diamond MI, Hartl FU, Hipp MS
Nat Commun. 2023 Feb 2;14(1):560. doi: 10.1038/s41467-023-36058-2. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 188572 | Tet-off TauRD (P301L/V337M) | Dox-repressible expression of the Tau repeat domain |
| 188573 | Tet-off Full length Tau (0N4R, P301L/V337M) | Dox-repressible expression of the 0N4R Tau isoform |