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A simplified function-first method for the discovery and optimization of bispecific immune engaging antibodies.
Shepherd A, Bennychen B, Marcil A, Bloemberg D, Pon RA, Weeratna RD, McComb S
PLoS One. 2023 Jun 22;18(6):e0273884. doi: 10.1371/journal.pone.0273884. eCollection 2023. PubMed Article

Plasmids from Article

ID Plasmid Purpose
190677pBITE-CD19-CD3Encodes a modularized form of HD37-OKT3 bispecific antibody
190679pBITE-EGFRvIII-F265-OKT3Encodes an EGFRvIII-CD3 BITE protein (F265 clone)
190680pBITE-EGFRvIII-F263-OKT3Encodes an EGFRvIII-CD3 BITE protein (F263 clone)
190681pBITE-EGFRvIII-F269-OKT3Encodes an EGFRvIII-CD3 BITE protein (F269 clone)
190682pBITE-EGFRvIII-F271-OKT3Encodes an EGFRvIII-CD3 BITE protein (F271 clone)

Antibodies from Article