Nested epistasis enhancer networks for robust genome regulation.
Lin X, Liu Y, Liu S, Zhu X, Wu L, Zhu Y, Zhao D, Xu X, Chemparathy A, Wang H, Cao Y, Nakamura M, Noordermeer JN, La Russa M, Wong WH, Zhao K, Qi LS
Science. 2022 Aug 11:eabk3512. doi: 10.1126/science.abk3512. PubMed Article
Lin X, Liu Y, Liu S, Zhu X, Wu L, Zhu Y, Zhao D, Xu X, Chemparathy A, Wang H, Cao Y, Nakamura M, Noordermeer JN, La Russa M, Wong WH, Zhao K, Qi LS
Science. 2022 Aug 11:eabk3512. doi: 10.1126/science.abk3512. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 190684 | pSLQ1373_mU6_sgRNA targeting e1 | sgRNA targeting enhancer 1 of MYC |
| 190685 | pSLQ1373_mU6_sgRNA targeting e3 | sgRNA targeting enhancer 3 of MYC |
| 190686 | pSLQ5004_hU6_sgRNA targeting e4 | sgRNA targeting enhancer 4 of MYC |
| 190687 | pSLQ5004_hU6_sgRNA targeting e7 | sgRNA targeting enhancer 7 of MYC |
| 190688 | double_sgRNA targeting e1 and e4 | sgRNAs targeting enhancer 1 and 4 of MYC separately |
| 190689 | double_sgRNA targeting e3 and e7 | sgRNAs targeting enhancer 3 and 7 of MYC separately |