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Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617.
Peng L, Hu Y, Mankowski MC, Ren P, Chen RE, Wei J, Zhao M, Li T, Tripler T, Ye L, Chow RD, Fang Z, Wu C, Dong MB, Cook M, Wang G, Clark P, Nelson B, Klein D, Sutton R, Diamond MS, Wilen CB, Xiong Y, Chen S
Nat Commun. 2022 Mar 28;13(1):1638. doi: 10.1038/s41467-022-29288-3.
PubMed Article

Plasmids from Article

ID Plasmid Purpose
192175HH02-LP Clone 2 heavy chainClone 2 heavy chain (HH02)
192176HH06-LP Clone 6 heavy chainClone 6 heavy chain (HH06)
192177HH13 Clone 13 heavy chainClone 13 heavy chain (HH013)
192178HH13A Clone 13A heavy chainClone 13A heavy chain (HH13A)
192179HK02-LP Clone 2 light chainClone 2 light chain (HK02)
192182HK13A Clone 13A light chainClone 13A light chain (HK13A)
192183Clone 16 - 1 HH02 pFUSE-IgG1-Hole mutation-hole-clone2Clone 16 (HH02) pFUSE-IgG1-Hole mutation-hole-clone2
192184Clone 16 - 2 HH06 pFUSE-IgG1-Knob-mutation knob-clone6Clone 16 (HH06) pFUSE-IgG1-Knob-mutation knob-clone6
192185Clone 16 - 3 HK02 pFUSE-IgG-human kappa VL-CH1 hole-clone2Clone 16 (HK02) pFUSE-IgG-human kappa VL-CH1 hole-clone2

Antibodies from Article