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Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease.
Zhou P, Song G, Liu H, Yuan M, He WT, Beutler N, Zhu X, Tse LV, Martinez DR, Schafer A, Anzanello F, Yong P, Peng L, Dueker K, Musharrafieh R, Callaghan S, Capozzola T, Limbo O, Parren M, Garcia E, Rawlings SA, Smith DM, Nemazee D, Jardine JG, Safonova Y, Briney B, Rogers TF, Wilson IA, Baric RS, Gralinski LE, Burton DR, Andrabi R
Immunity. 2023 Mar 14;56(3):669-686.e7. doi: 10.1016/j.immuni.2023.02.005. Epub 2023 Feb 16.
PubMed Article

Plasmids from Article

ID Plasmid Purpose
194493pcDNA3.3_SARS2_BQ.1.1expressing SARS-CoV-2 BQ.1.1 spike protein for pseudovirus production
194494pcDNA3.3_SARS2_XBBexpressing SARS-CoV-2 XBB spike protein for pseudovirus production

Antibodies from Article