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Fully murine CD105-targeted CAR-T cells provide an immunocompetent model for CAR-T cell biology.
Lontos K, Wang Y, Colbert M, Kumar A, Joshi S, Philbin M, Wang Y, Frisch A, Lohmueller J, Rivadeneira DB, Delgoffe GM
Oncoimmunology. 2022 Oct 18;11(1):2131229. doi: 10.1080/2162402X.2022.2131229. eCollection 2022. PubMed Article

Plasmids from Article

ID Plasmid Purpose
193942pMSGV-mCD105scFv-myc-CD28HTMcostim-T2A-Thy1.1a fully murine CAR targeting CD105 (endoglin), a component of the TGFβ receptor expressed on the surface of certain solid tumors and acute leukemias.

Antibodies from Article