The effects of allosteric and competitive inhibitors on ZIKV protease conformational dynamics explored through smFRET, nanoDSF, DSF, and (19)F NMR.
Maus H, Hammerschmidt SJ, Hinze G, Barthels F, Perez Carrillo VH, Hellmich UA, Basche T, Schirmeister T
Eur J Med Chem. 2023 Oct 5;258:115573. doi: 10.1016/j.ejmech.2023.115573. Epub 2023 Jun 21. PubMed Article
Maus H, Hammerschmidt SJ, Hinze G, Barthels F, Perez Carrillo VH, Hellmich UA, Basche T, Schirmeister T
Eur J Med Chem. 2023 Oct 5;258:115573. doi: 10.1016/j.ejmech.2023.115573. Epub 2023 Jun 21. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 198432 | 5ZiPro | Conformation sensitive site specific Cys-labeling |
| 198434 | eZiPro | Activity/inhibition assays, 19F-NMR |
| 198435 | eZiPro W61*F | Activity/inhibition assays, 19F-NMR assignment |
| 198436 | eZiPro W5F | Activity/inhibition assays, 19F-NMR assignment |
| 198437 | eZiPro W50F | Activity/inhibition assays, 19F-NMR assignment |
| 198438 | eZiPro W69F | Activity/inhibition assays, 19F-NMR assignment |
| 198439 | eZiPro W83F | Activity/inhibition assays, 19F-NMR assignment |
| 198440 | eZiPro W89F | Activity/inhibition assays, 19F-NMR assignment |
| 198441 | gZiPro | Activity/inhibition assays, 19F-NMR |
| 198442 | gZiPro W61*F | Activity/inhibition assays, 19F-NMR assignment |
| 198443 | gZiPro W5F | Activity/inhibition assays, 19F-NMR assignment |
| 198444 | gZiPro W50F | Activity/inhibition assays, 19F-NMR assignment |
| 198445 | gZiPro W69F | Activity/inhibition assays, 19F-NMR assignment |
| 198446 | gZiPro W83F | Activity/inhibition assays, 19F-NMR assignment |
| 198447 | gZiPro W89F | Activity/inhibition assays, 19F-NMR assignment |