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Comprehensive AAV capsid fitness landscape reveals a viral gene and enables machine-guided design.
Ogden PJ, Kelsic ED, Sinai S, Church GM
Science. 2019 Nov 29;366(6469):1139-1143. doi: 10.1126/science.aaw2900. PubMed Article

Plasmids from Article

ID Plasmid Purpose
199599pRepExpresses AAV2 rep gene; accessory plasmid for the pCMV-Cap SSM library.
199601pRep-Cap Scanning Saturation Mutagenesis (SSM) pooled librarypRep-Cap SSM library enables VP1, VP2, and VP3 expression under the control of the endogenous p40 promoter

Antibodies from Article