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Gasdermin D pore-forming activity is redox-sensitive.
Devant P, Borsic E, Ngwa EM, Xiao H, Chouchani ET, Thiagarajah JR, Hafner-Bratkovic I, Evavold CL, Kagan JC
Cell Rep. 2023 Jan 31;42(1):112008. doi: 10.1016/j.celrep.2023.112008. Epub 2023 Jan 19. PubMed Article

Plasmids from Article

ID Plasmid Purpose
201166pMSCV-GSDMD-MycExpression of GSDMD gene in mammalian cells by retroviral transduction
201167pMSCV-GSDMD_C39A-MycExpression of GSDMD gene in mammalian cells by retroviral transduction
201168pMSCV-GSDMD_C192A-MycExpression of GSDMD gene in mammalian cells by retroviral transduction
201169pMSCV-GSDMD_NoCys-MycExpression of GSDMD gene in mammalian cells by retroviral transduction
201170pRetroX-TRE3G_NT-GSDMDDox-inducible expression of NT-GSDMD gene in mammalian cells by retroviral transduction
201171pRetroX-TRE3G_NT-GSDMD_C39ADox-inducible expression of NT-GSDMD gene in mammalian cells by retroviral transduction
201172pRetroX-TRE3G_NT-GSDMD_C192ADox-inducible expression of NT-GSDMD gene in mammalian cells by retroviral transduction
201173pRetroX-TRE3G_NT-GSDMD_NoCysDox-inducible expression of NT-GSDMD gene in mammalian cells by retroviral transduction
201174pRetroX-TRE3G_NT-GSDMD_I105N_Dox-inducible expression of NT-GSDMD gene in mammalian cells by retroviral transduction
201175pRetroX-TRE3G_NT-GSDMD_I105N_C39ADox-inducible expression of NT-GSDMD gene in mammalian cells by retroviral transduction
201176pRetroX-TRE3G_NT-GSDMD_I105N__C192ADox-inducible expression of NT-GSDMD gene in mammalian cells by retroviral transduction
201177pRetroX-TRE3G_NT-GSDMD_I105N_NoCysDox-inducible expression of NT-GSDMD gene in mammalian cells by retroviral transduction
201178pRetroX-TRE3G_NT-GSDMD_I105N_C192onlyDox-inducible expression of NT-GSDMD gene in mammalian cells by retroviral transduction

Antibodies from Article