Mutated ATP10B increases Parkinson's disease risk by compromising lysosomal glucosylceramide export.
Martin S, Smolders S, Van den Haute C, Heeman B, van Veen S, Crosiers D, Beletchi I, Verstraeten A, Gossye H, Gelders G, Pals P, Hamouda NN, Engelborghs S, Martin JJ, Eggermont J, De Deyn PP, Cras P, Baekelandt V, Vangheluwe P, Van Broeckhoven C
Acta Neuropathol. 2020 Jun;139(6):1001-1024. doi: 10.1007/s00401-020-02145-7. Epub 2020 Mar 14. PubMed Article
Martin S, Smolders S, Van den Haute C, Heeman B, van Veen S, Crosiers D, Beletchi I, Verstraeten A, Gossye H, Gelders G, Pals P, Hamouda NN, Engelborghs S, Martin JJ, Eggermont J, De Deyn PP, Cras P, Baekelandt V, Vangheluwe P, Van Broeckhoven C
Acta Neuropathol. 2020 Jun;139(6):1001-1024. doi: 10.1007/s00401-020-02145-7. Epub 2020 Mar 14. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 203694 | pcDNA3_CDC50A | expresses CDC50A |
| 203695 | pcDNA3_ATP10B | expresses ATP10B |
| 203696 | pcDNA3_ATP10B-D433N | expresses ATP10B with the catalytic mutation D433N |
| 203697 | pcDNA3_ATP10B-E210A | expresses ATP10B with the catalytic mutation E210A |
| 203698 | pcDNA3_ATP10B-E993A | expresses ATP10B with the pathogenic mutation E993A |
| 203699 | pcDNA3_ATP10B-G671R-N865K | expresses ATP10B with the pathogenic mutations G671R and N865K |
| 203700 | pcDNA3_ATP10B-I1038T | expresses ATP10B with the pathogenic mutation I1038T |
| 203701 | pcDNA3_ATP10B-R153X | expresses ATP10B with the pathogenic mutation R153X |
| 203702 | pcDNA3_ATP10B-V748L | expresses ATP10B with the pathogenic mutation V748L |