Adenine base editor-based correction of the cardiac pathogenic Lmna c.1621C > T mutation in murine hearts.
Yang L, Liu Z, Sun J, Chen Z, Gao F, Guo Y
J Cell Mol Med. 2024 Feb;28(4):e18145. doi: 10.1111/jcmm.18145. PubMed Article
Yang L, Liu Z, Sun J, Chen Z, Gao F, Guo Y
J Cell Mol Med. 2024 Feb;28(4):e18145. doi: 10.1111/jcmm.18145. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 206967 | pAAV-CMV-TadA7.10-SpG N aa2-713-InteinN | Expresses TadA7.10 and SpG cas9N by the constitutive CMV promoter |
| 206968 | pAAV-CMV-TadA8e-SpG N aa2-713-InteinN | Expresses TadA8e and SpG cas9N by the constitutive CMV promoter |
| 206974 | pAAV-CASI-InteinC-NG C aa714-1368-U6-Lmna sgRNA1 | Expresses NG cas9C by the constitutive CASI promoter and sgRNA targeting murine Lmna c.1621T mutation by U6 promoter |
| 206979 | pAAV-EFS-TadA8e-Sauri-U6-Lmna sgRNA | Expresses SauriABE8e by EFS promoter and sgRNA targeting murine Lmna c.1621T mutation by U6 promoter |
| 208110 | pAAV-CASI-InteinC-SpG C aa714-1368-U6-Lmna sgRNA1 | Expresses SpG cas9C by the constitutive CASI promoter and sgRNA targeting murine Lmna c.1621T mutation by U6 promoter |
| 208111 | pAAV-CASI-inteinC-aa713 SpG C-U6- sgRNA scaffold | Expresses SpG cas9C by the constitutive CASI promoter and sgRNA scaffold by U6 promoter |