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PRL3 pseudophosphatase activity is necessary and sufficient to promote metastatic growth.
Kozlov G, Funato Y, Chen YS, Zhang Z, Illes K, Miki H, Gehring K
J Biol Chem. 2020 Aug 14;295(33):11682-11692. doi: 10.1074/jbc.RA120.014464. Epub 2020 Jun 22.
PubMed Article

Plasmids from Article

ID Plasmid Purpose
209792hPRL1_1-169Bacterial expression of human PRL-1 without farnesylation motif
209793hPRL1_1-169_C104DBacterial expression of human PRL-1 C104D mutant without farnesylation motif
209794hPRL2_1-163Bacterial expression of human PRL-2 without farnesylation motif
209797hPRL3_1-169_C104DBacterial expression of human PRL-3 C104D mutant without farnesylation motif

Antibodies from Article