Cooperativity between Cas9 and hyperactive AID establishes broad and diversifying mutational footprints in base editors.
Berrios KN, Barka A, Gill J, Serrano JC, Bailer PF, Parker JB, Evitt NH, Gajula KS, Shi J, Kohli RM
Nucleic Acids Res. 2024 Jan 23:gkae024. doi: 10.1093/nar/gkae024. PubMed Article
Berrios KN, Barka A, Gill J, Serrano JC, Bailer PF, Parker JB, Evitt NH, Gajula KS, Shi J, Kohli RM
Nucleic Acids Res. 2024 Jan 23:gkae024. doi: 10.1093/nar/gkae024. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 216729 | AID-C12*-BE4max | Expresses a BE4max base editing construct comprised of the hyperactive AID-C12* and nCas9 (Cas9 with D10A mutation) in mammalian cells. |
| 216731 | AID-C12*-dCas9-BE4max | Expresses a BE4max base editing construct comprised of the hyperactive AID-C12* and dCas9 (Cas9 with D10A and H840A mutations) in mammalian cells. |