Development of receptor and oncogene-responsive luciferase reporter vectors that are activated via kinase signaling to AP-1.
Coleman DJL, Ames L, Aain H, Gamble J, Koscielniak K, Zhang Z, Lau C, Joyce A, Cockerill PN
Exp Hematol. 2026 Sep;161:105491. doi: 10.1016/j.exphem.2026.105491. Epub 2026 Aug 13.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 71258 | pAP1-3 | luciferase reporter with 3 copies of the stromelylisin gene AP-1 site in front of hGM-CSF -55 to +28 minimal promoter |
| 217413 | LEGO-GM55 | Luciferase expression vector with the minimal GM-CSF promoter |
| 217414 | LEGO-AP1x3-GM55 | Luciferase expression vector with 3 AP-1 sites and the minimal GM-CSF promoter. Alias: LEGO-GM55-AP-1x3 |
| 217415 | LEGO-AP1x6-GM55 | Luciferase expression vector with 6 AP-1 sites and the minimal GM-CSF promoter. Alias: LEGO-GM55-AP-1x6 |
| 217416 | LEGO-pDHS-AP1x6-GM55 | Luciferase expression vector with 6 AP-1 sites and the minimal GM-CSF promoter, and a chromatin priming element. Alias: LEGO-GM55-AP-1x6-pDHS(IL-3) |
| 217417 | LEGO-pDHS-AP1x6-MGM264 | Luciferase expression vector with 6 AP-1 sites and the full length GM-CSF promoter, and a chromatin priming element. Alias: LEGO-MGM264-AP-1x6 |
| 217418 | LEGO-pDHS-AP1x6-DUSP5 | Luciferase expression vector with 6 AP-1 sites and the full length DUSP5 promoter, and a chromatin priming element. Alias: LEGO-DUSP5p-AP-1x6 |
| 217419 | LEGO-pDHS-ITDE-AP1x6-DUSP5 | Luciferase expression vector with an oncogene-inducible enhancer, 6 AP-1 sites, the full length DUSP5 promoter, and a chromatin priming element. Alias: LEGO-DUSP5p-AP-1x6-ITDe |