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RHOBTB3 promotes proteasomal degradation of HIFalpha through facilitating hydroxylation and suppresses the Warburg effect.

Zhang CS, Liu Q, Li M, Lin SY, Peng Y, Wu D, Li TY, Fu Q, Jia W, Wang X, Ma T, Zong Y, Cui J, Pu C, Lian G, Guo H, Ye Z, Lin SC
Cell Res. 2015 Sep;25(9):1025-42. doi: 10.1038/cr.2015.90. Epub 2015 Jul 28. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
246211pBOBI N-HA HIF2aUsed for transfection of cells for expression N-HA HIF2a
246212pBOBI N-FLAG HIF2aUsed for transfection of cells for expression N-FLAG HIF2a
246216CMV5 N-HA hHIF1a P402AUsed for transfection of cells for expression N-HA hHIF1a P402A

Antibodies from Article