Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule.
Bielskute-Garcia S, Mateos B, Awawdy M, Garcia-Cabau C, Niskanen H, Sanchez-Zarzalejo C, Bracaglia L, Pierattelli R, Felli IC, Frigole-Vivas M, Garcia J, Riera A, Hnisz D, Salvatella X
Sci Adv. 2026 Feb 27;12(9):eadz7400. doi: 10.1126/sciadv.adz7400. Epub 2026 Feb 27.
(Link opens in a new window)
PubMed
(Link opens in a new window)
Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 249247 | pJM118_CFP-hFUS-IDR | For overexpression of CFP-LacI-hFUD-IDR |
| 249248 | pJM118-CFP-LacI-AR_NTD_Human | For overexpression of CFP-LacI-AR-NTD |
| 249249 | pJM118-CFP-LacI-ER_NTD_Human | For overexpression of CFP-LacI-ER-NTD |
| 249250 | pJM118-CFP-LacI-NR3C1(GR)_NTD_Human | For overexpression of CFP-LacI-GR-NTD |
| 249251 | pJM118-CFP-LacI-NR3C2(MR)_NTD_Human | For overexpression of CFP-LacI-MR-NTD |
| 249252 | pJM118-CFP-LacI-PGR(PR)_NTD_Human | For overexpression of CFP-LacI-PR-NTD |
| 249253 | pJM118_CFP-LacI-MCS | For overexpression of CFP-LacI |
| 249254 | pHR_RNAPII_CTD_YFP | For overexpression of RNAPII.CTD-YFP |