Pyroglutamation of cell surface proteins CD47 and TRP1 by glutaminyl cyclase modulates therapeutic antibody binding.
van der Plas-van Duijn A, Winkelman LMT, Lensen C, van Duivendijk M, Derksen I, van Veenendaal JMF, Schaap G, Sluijter M, van Groningen TJB, van Doorn R, van Hall T, Slieker RC, Sharp TH, Beltman JB, Bresser K, Scheeren FA
Commun Biol. 2025 Nov 13;8(1):1561. doi: 10.1038/s42003-025-08938-4.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 242866 | cleaveBADTrp | Expression of cleavable Trp1 (extracellular domain) |
| 242867 | Trp1-WT-display | Expression of ECD of WT- Trp1 fused to display TMD. |
| 242868 | Trp1-Ala-display | Expression of ECD of Trp-1-ala fused to display TMD. |