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Calcium-independent biosensors for multiplexed in vivo imaging of extracellular lactate dynamics

Liu J, Mizuno H, Than-Trong E, Machler P, Kubotera H, Barbay T, Wang C, To Q, Kamijo Y, Nishimura T, Boisvert M, Paquet M, Drobizhev M, Cragg SJ, Nagai J, Kleinfeld D, Charpak S, Nasu Y
bioRxiv October 5, 2026 (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
256032pBAD-R-iLACCO2HBiosensor for intracellular L-lactate
256033pBAD-R-iLACCO2MBiosensor for intracellular L-lactate
256034pBAD-R-iLACCO2LBiosensor for intracellular L-lactate
256035pBAD-R-diLACCO2ctrlBiosensor for intracellular L-lactate
256036pBAD-iLACCO2HBiosensor for intracellular L-lactate
256037pBAD-iLACCO2LBiosensor for intracellular L-lactate
256038pBAD-iLACCO2MBiosensor for intracellular L-lactate
256039pBAD-diLACCO2ctrlBiosensor for intracellular L-lactate
256040pcDNA-R-eLACCO3HBiosensor for extracellular L-lactate
256041pcDNA-R-eLACCO3MBiosensor for extracellular L-lactate
256042pcDNA-R-eLACCO3LBiosensor for extracellular L-lactate
256043pcDNA-R-deLACCO3ctrlBiosensor for extracellular L-lactate
256044pcDNA-R-iLACCO2HBiosensor for intracellular L-lactate
256045pcDNA-R-iLACCO2MBiosensor for intracellular L-lactate
256046pcDNA-R-iLACCO2LBiosensor for intracellular L-lactate
256047pcDNA-R-diLACCO2ctrlBiosensor for intracellular L-lactate
256048pcDNA-iLACCO2HBiosensor for intracellular L-lactate
256049pcDNA-iLACCO2LBiosensor for intracellular L-lactate
256050pcDNA-iLACCO2MBiosensor for intracellular L-lactate
256051pcDNA-diLACCO2ctrlBiosensor for intracellular L-lactate
256052pcDNA-eLACCO3HBiosensor for extracellular L-lactate
256053pcDNA-eLACCO3LBiosensor for extracellular L-lactate
256054pcDNA-eLACCO3MBiosensor for extracellular L-lactate
256055pcDNA-deLACCO3ctrlBiosensor for extracellular L-lactate

Antibodies from Article