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Receptor-Guided AAV Tropism Engineering via MATCH.

Graham N, Kumar S, Rainaldi J, Yang S, Portell A, Santoso B, Mali P
ACS Synth Biol. 2026 May 23. doi: 10.1021/acssynbio.5c00910. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
258656pAAV-AAV-DJ-SpyTagEncodes the AAV-DJ capsid with SpyTag001 inserted after VP1 residue 589 and flanked by GSS linkers.
258657pAAV-AAV9_Loop1_SpyTag_2xGSSEncodes the AAV9 capsid with SpyTag001 inserted after VP1 residue 456 and flanked by 2xGSS linkers.
258658pAAV-AAV9_Loop2_SpyTag_2xGSSEncodes the AAV9 capsid with SpyTag001 inserted after VP1 residue 587 and flanked by 2xGSS linkers.
258659pCAG-αCD3-scFv-1-SpyCatcherMammalian expression vector encoding SpyCatcher-linked αCD3-scFv-1

Antibodies from Article