Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognition.
Wang Q, Young P, Walters KJ
J Mol Biol. 2005 May 6;348(3):727-39. doi: 10.1016/j.jmb.2005.03.007.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 260881 | pET26b S5a(196-306) | S5a(196-306) contains two ubiquitin-interacting motifs (UIMs) through which S5a/RPN10/PSMD4 recruits ubiquitylated substrates to the proteasome for their degradation. |
| 260882 | pGEX-6P S5a (196-272) | S5a/RPN10/PSMD4 ubiquitin-interacting motif 1 (UIM1) |
| 260883 | pGEX-6P S5a (273-306) | S5a/RPN10/PSMD4 ubiquitin-interacting motif 2 (UIM2) |