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Non-invasive control of gene editing in vivo by photoswitchable Cas12f and focused ultrasound.

Song D, Malinao MG, Wu X, Jiang S, Jiang D, Westberg M, Su Y, Cai S, Lee D, Repina NA, Schaffer DV, Ji HP, Hong G, Lin MZ
Cell. 2026 Sep 28:S0092-8674(26)01074-3. doi: 10.1016/j.cell.2026.09.005. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
261716pAAV-U6-sgRNA (LSL targeting)-CMV-ps2-CasMINIloxP-STOP-loxP (LSL) gene editing using ps2-CasMINI
261717pAAV-U6-sgRNA (LSL targeting)-CMV-ps2-eCas12f1loxP-STOP-loxP (LSL) gene editing using ps2-eCas12f1
261718pAAV-U6-sgRNA (LSL targeting)-CMV-ps2-AsCas12f-HKRAloxP-STOP-loxP (LSL) gene editing using ps2-AsCas12f-HKRA
261720pAAV-U6-sgRNA (TTR targeting)-HCRhAAT-ps2-eCas12f1TTR gene editing using ps2-eCas12f1

Antibodies from Article