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The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism.
Yang C, Tan W, Whittle C, Qiu L, Cao L, Akbarian S, Xu Z
PLoS One. 2010 . 5(12):e15878.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
28195tdp43-EGFP construct2
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28196tdp43-EGFP construct3
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28197tdp43-EGFP construct4
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28198tdp43-EGFP construct5
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28199tdp43-EGFP construct6
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28200tdp43-EGFP construct7
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28201tdp43-EGFP construct8
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28202tdp43-EGFP construct9
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28203tdp43-EGFP construct10
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28204tdp43-EGFP construct11
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28205wtTDP43tdTOMATOHA
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28206TDP43 NOTAG1
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28207TDP43 NOTAG2
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28208TDP43 NOTAG3
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28209TDP43 NOTAG6
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28210TDP43 NOTAG11
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28211miR-TDP43a
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28212miR-TDP43b
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Antibodies from Article