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Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration.
Perciavalle RM, Stewart DP, Koss B, Lynch J, Milasta S, Bathina M, Temirov J, Cleland MM, Pelletier S, Schuetz JD, Youle RJ, Green DR, Opferman JT
Nat Cell Biol. 2012 Apr 29;14(6):575-83. doi: 10.1038/ncb2488.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
45818pMSCV-puro-5A, 6A mMCL1-OM
45819pMSCV-puro-Delta N67-mMCL1
45820pMSCV-puro-mMCL1 Delta C22
45822pMSCV-puro-AS9 (Mito MTS)-Delta N67-mMCL1
45823pMSCV-puro-Delta-ATG1-mMCL1This plasmid was made to show that the two MCL-1 bands DO NOT arise from a non-canonical translation initiation downstream of the start codon.