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Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration.
Perciavalle RM, Stewart DP, Koss B, Lynch J, Milasta S, Bathina M, Temirov J, Cleland MM, Pelletier S, Schuetz JD, Youle RJ, Green DR, Opferman JT
Nat Cell Biol. 2012 Apr 29;14(6):575-83. doi: 10.1038/ncb2488.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
45817pMSCV-puro-mMCL1-WT
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45818pMSCV-puro-5A, 6A mMCL1-OM
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45819pMSCV-puro-Delta N67-mMCL1
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45820pMSCV-puro-mMCL1 Delta C22
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45822pMSCV-puro-AS9 (Mito MTS)-Delta N67-mMCL1
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45823pMSCV-puro-Delta-ATG1-mMCL1This plasmid was made to show that the two MCL-1 bands DO NOT arise from a non-canonical translation initiation downstream of the start codon.
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