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Occludin is a direct target of thyroid transcription factor-1 (TTF-1/NKX2-1).

Runkle EA, Rice SJ, Qi J, Masser D, Antonetti DA, Winslow MM, Mu D
J Biol Chem. 2012 Aug 17;287(34):28790-801. doi: 10.1074/jbc.M112.367987. Epub 2012 Jul 2. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
46387pGL4.10-Claudin-1Claudin-1 promoter reporter assay
49989pcDNA3.1(+)-wt-TTF-1For transient transfection to express human wild type TTF-1 protein
52063pcDNA3.1(+)-TTF-1-HDDIt encodes a mutant of TTF-1 in which the homeodomain is deleted
75084pMSCV-hygro-TTF-1 Q210K-Y214Mretroviral vector containing human TTF-1 mutant cDNA
75264pcDNA3.1(+)-TTF-1-Q50K-Y54MExpresses a double point mutant of human TTF-1
75265pcDNA3.1(+)-TTF-1-AD1-deletionExpresses a deletion mutant of human TTF-1 lacking the activation domain 1
75266pcDNA3.1(+)-TTF-1-AD2-deletionExpresses a deletion mutant of human TTF-1 lacking the activation domain 2
88868SFTPB Promoter reporterSurfactant Protein B Gene Promoter Reporter

Antibodies from Article