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Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.
Calvo SE, Pagliarini DJ, Mootha VK
Proc Natl Acad Sci U S A. 2009 May 5;106(18):7507-12. doi: 10.1073/pnas.0810916106. Epub 2009 Apr 16.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
48158psicheck-2-Acsm2contains Renilla Luciferase gene preceded by an intact (ATG) upstream open reading frame element
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48159psicheck-2-Acsm2 modcontains Renilla Luciferase gene preceded by a mutated (ATG --> TTG) upstream open reading from element
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48160psicheck-2-Slc25a15contains Renilla Luciferase gene preceded by an intact (ATG) upstream open reading frame element
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48161psicheck-2-Slc25a15 modcontains Renilla Luciferase gene preceded by a mutated (ATG --> TTG) upstream open reading from element
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48162psicheck-2-Phbcontains Renilla Luciferase gene preceded by an intact (ATG) upstream open reading frame element
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48163psicheck-2-Phb modcontains Renilla Luciferase gene preceded by a mutated (ATG --> TTG) upstream open reading from element
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48164psicheck-2-Mutcontains Renilla Luciferase gene preceded by an intact (ATG) upstream open reading frame element
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48165psicheck-2-Mut modcontains Renilla Luciferase gene preceded by a mutated (ATG --> TTG) upstream open reading from element
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48166psicheck-2-Mrpl1contains Renilla Luciferase gene preceded by an intact (ATG) upstream open reading frame element
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48167psicheck-2-LPPRCcontains Renilla Luciferase gene preceded by an intact (ATG) upstream open reading frame element
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48168psicheck-2-LPPRC-modcontains Renilla Luciferase gene preceded by a mutated (ATG --> TTG) upstream open reading frame element
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48169psicheck-2-Sfxn3contains Renilla Luciferase gene preceded by an intact (ATG) upstream open reading frame element
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48170psicheck-2-Sfxn3-modcontains Renilla Luciferase gene preceded by a mutated (ATG --> TTG) upstream open reading frame element
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48171psicheck-2-Casp8-modcontains Renilla Luciferase gene preceded by a mutated (ATG --> ATT) upstream open reading frame element
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48172psicheck-2-Casp8contains Renilla Luciferase gene preceded by an intact (ATG) upstream open reading frame element
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48173psicheck-2-Mc2r-modcontains Renilla Luciferase gene preceded by a mutated (ATG --> GTG) upstream open reading frame element
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48174psicheck-2-Mc2rcontains Renilla Luciferase gene preceded by an intact (ATG) upstream open reading frame element
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48175psicheck-2-Tas2r3-modcontains Renilla Luciferase gene preceded by a mutated (ATG --> ACG) upstream open reading frame element
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48176psicheck-2-Tas2r3contains Renilla Luciferase gene preceded by an intact (ATG) upstream open reading frame element
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48177psicheck-2-Kdr-modcontains Renilla Luciferase gene preceded by a mutated (ATG --> GTG) upstream open reading frame element
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48178psicheck-2-Kdrcontains Renilla Luciferase gene preceded by an intact (ATG) upstream open reading frame element
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48179psicheck-2-Hsdl2contains Renilla Luciferase gene preceded by an intact (ATG) upstream open reading frame element
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48180psicheck-2-Hsdl2-modcontains Renilla Luciferase gene preceded by a mutated (ATG --> TTG) upstream open reading frame element
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49569psicheck-2-Mrpl11-modcontains Renilla Luciferase gene preceded by a mutated (ATG --> TTG) upstream open reading frame element
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