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The let-7/LIN-41 pathway regulates reprogramming to human induced pluripotent stem cells by controlling expression of prodifferentiation genes.
Worringer KA, Rand TA, Hayashi Y, Sami S, Takahashi K, Tanabe K, Narita M, Srivastava D, Yamanaka S
Cell Stem Cell. 2014 Jan 2;14(1):40-52. doi: 10.1016/j.stem.2013.11.001. Epub 2013 Nov 14.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
52716pMXs-hs-LIN-41retroviral expression of human LIN-41 / TRIM71
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52717pMXS-hs-3xHA-LIN-41retroviral expression of human LIN-41 / TRIM71 with 3 N-terminal HA tags
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52718pMXs-hs-3xHA-deltaRING-LIN-41retroviral expression of human LIN-41 / TRIM71 containing a RING domain deletion and 3 N-terminal HA tags
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52719pMXs-hs-3xHA-deltaBBox-LIN-41retroviral expression of human LIN-41 / TRIM71 containing deletion of the BBox domain and 3 N-terminal HA tags
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52720pMXs-hs-3xHA-deltaCoiledCoil-LIN-41retroviral expression of human LIN-41 / TRIM71 containing deletion of the Coiled Coil domain and 3 N-terminal HA tags
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52721pMXs-hs-3xHA-deltaFilamin-LIN-41retroviral expression of human LIN-41 / TRIM71 containing deletion of the Filamin domain and 3 N-terminal HA tags
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52722pMXs-hs-3xHA-delta6xNHL-LIN-41retroviral expression of human LIN-41 / TRIM71 containing deletion of the 6xNHL repeats and 3 N-terminal HA tags
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52723pMXs-hs-3xHA-NHL only-LIN-41retroviral expression of human LIN-41 / TRIM71 containing only the NHL repeats and 3 N-terminal HA tags
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52724pMXs-hs-EGR1retroviral expression of human EGR1
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52725pMXs-hs-3xHA-C12AC15A-LIN-41retroviral expression of human LIN-41 / TRIM71 containing cysteine to alanine point mutations at cysteine 12 and 15 and 3 N-terminal HA tags
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52726pMXs-hs-3xHA-7CtoA-LIN-41retroviral expression of human LIN-41 / TRIM71 containing cysteine to alanine point mutations of all 7 cysteines in the RING domain and 3 N-terminal HA tags
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52727pMXS-hs-HMGA2retroviral expression of human HMGA2
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52728pMXs-hs-NRASretroviral expression of human NRAS
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52729pMXs-hs-KRASretroviral expression of human KRAS
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52730pMXs-hs-HRASretroviral expression of human HRAS
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52731pMXs-hs-CDC34retroviral expression of human CDC34
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