We narrowed to 3 results for: broad host range

...human, mouse, and rat reference genomes. Hosted by the Broad GPP and developed by the John Doench , David...sequence and checks for off-target binding. Supports a range of Cas enzymes (Cas9 and Cas12) and organisms. Developed...gene inactivation, NHEJ, and HDR. Includes a wide range of reference genomes, including animals, plants,...and cytosine (CBE) base editors. Includes a wide range of reference genomes, including animals, plants,...for off-target binding. Currently supports a wide range of organims. Developed by the Michael Boutros Lab...

...invading phages and plasmids. CRISPR loci in microbial hosts contain a combination of CRISPR-associated (Cas)...vectors that can be combined with Cas9 in a wide range of applications. Full references are below. The ... studying the function of genetic elements. To broadly enable the application of Cas9 in vivo and ex vivo...

... DNA, which scientists have modified for a wide range of genome engineering techniques . Collectively,... often found in plants, expanding the targeting range for plant genome engineering. Read more about Cas9...non-specifically. Cas12a also has an expanded targeting range to AT-rich regions, as it recognizes TTTV (V = A.... R., Maxwell, K. L., & Doudna, J. A. (2017). A Broad-Spectrum inhibitor of CRISPR-Cas9. Cell , 170 (6...& Liu, D. R. (2018). Evolved Cas9 variants with broad PAM compatibility and high DNA specificity. Nature...screens in E. coli identify essential genes and phage host factors. PLOS Genetics . 14 (11), e1007749. PMID...with increased activities and improved targeting ranges for gene, epigenetic and base editing. Nature Biotechnology...