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pCMV5B-Flag-Smurf2 wt Citations (9)

Originally described in: Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation.
Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, Wrana JL Mol Cell. 2000 Dec . 6(6):1365-75. PubMed Journal

Articles Citing pCMV5B-Flag-Smurf2 wt

Articles
Smurf2 regulates IL17RB by proteasomal degradation of its novel binding partner DAZAP2. Popova A, Kzhyshkowska J, Nurgazieva D, Goerdt S, Gratchev A. Immunobiology. 2012 Mar;217(3):321-8. doi: 10.1016/j.imbio.2011.10.004. Epub 2011 Oct 20. PubMed
Functional characterization of a WWP1/Tiul1 tumor-derived mutant reveals a paradigm of its constitutive activation in human cancer. Courivaud T, Ferrand N, Elkhattouti A, Kumar S, Levy L, Ferrigno O, Atfi A, Prunier C. J Biol Chem. 2015 Jul 7. pii: jbc.M115.642314. PubMed
E3 Ubiquitin Ligase NEDD4 Promotes Influenza Virus Infection by Decreasing Levels of the Antiviral Protein IFITM3. Chesarino NM, McMichael TM, Yount JS. PLoS Pathog. 2015 Aug 11;11(8):e1005095. doi: 10.1371/journal.ppat.1005095. eCollection 2015 Aug. PubMed

Associated Plasmids
RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor beta signaling. Malonis RJ, Fu W, Jelcic MJ, Thompson M, Canter BS, Tsikitis M, Esteva FJ, Sanchez I. J Biol Chem. 2017 May 5;292(18):7435-7451. doi: 10.1074/jbc.M117.783662. Epub 2017 Mar 14. PubMed
The MAPK Erk5 is necessary for proper skeletogenesis involving a Smurf-Smad-Sox9 molecular axis. Iezaki T, Fukasawa K, Horie T, Park G, Robinson S, Nakaya M, Fujita H, Onishi Y, Ozaki K, Kanayama T, Hiraiwa M, Kitaguchi Y, Kaneda K, Yoneda Y, Takarada T, Guo XE, Kurose H, Hinoi E. Development. 2018 Jul 26;145(14). pii: dev.164004. doi: 10.1242/dev.164004. PubMed
Protein kinase CK2 activation is required for transforming growth factor beta-induced epithelial-mesenchymal transition. Kim S, Ham S, Yang K, Kim K. Mol Oncol. 2018 Oct;12(10):1811-1826. doi: 10.1002/1878-0261.12378. Epub 2018 Sep 21. PubMed
MiR-195 and miR-497 suppress tumorigenesis in lung cancer by inhibiting SMURF2-induced TGF-beta receptor I ubiquitination. Chae DK, Park J, Cho M, Ban E, Jang M, Yoo YS, Kim EE, Baik JH, Song EJ. Mol Oncol. 2019 Dec;13(12):2663-2678. doi: 10.1002/1878-0261.12581. Epub 2019 Nov 8. PubMed
Ubiquitin Ligase SMURF2 Interacts with Filovirus VP40 and Promotes Egress of VP40 VLPs. Shepley-McTaggart A, Schwoerer MP, Sagum CA, Bedford MT, Jaladanki CK, Fan H, Cassel J, Harty RN. Viruses. 2021 Feb 12;13(2). pii: v13020288. doi: 10.3390/v13020288. PubMed
The miR-15b-Smurf2-HSP27 axis promotes pulmonary fibrosis. Jeon S, Jin H, Kim JM, Hur Y, Song EJ, Lee YJ, Na Y, Cho J, Lee YS. J Biomed Sci. 2023 Jan 7;30(1):2. doi: 10.1186/s12929-023-00896-5. PubMed

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