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M50 Super 8x TOPFlash Citations (316)

Plasmid Article: Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements.
Veeman MT, Slusarski DC, Kaykas A, Louie SH, Moon RT Curr Biol. 2003 Apr 15. 13(8):680-5.
PubMed Journal

Articles Citing M50 Super 8x TOPFlash

Articles
Bacillus anthracis edema toxin activates nuclear glycogen synthase kinase 3beta. Larabee JL, DeGiusti K, Regens JL, Ballard JD. Infect Immun. 2008 Nov;76(11):4895-904. doi: 10.1128/IAI.00889-08. Epub 2008 Sep 2. PubMed
AMP-activated protein kinase (AMPK) cross-talks with canonical Wnt signaling via phosphorylation of beta-catenin at Ser 552. Zhao J, Yue W, Zhu MJ, Sreejayan N, Du M. Biochem Biophys Res Commun. 2010 Apr 23;395(1):146-51. doi: 10.1016/j.bbrc.2010.03.161. Epub 2010 Mar 31. PubMed
A muscle resident cell population promotes fibrosis in hindlimb skeletal muscles of mdx mice through the Wnt canonical pathway. Trensz F, Haroun S, Cloutier A, Richter MV, Grenier G. Am J Physiol Cell Physiol. 2010 Nov;299(5):C939-47. doi: 10.1152/ajpcell.00253.2010. Epub 2010 Sep 1. PubMed
Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation. Reddy VS, Valente AJ, Delafontaine P, Chandrasekar B. J Cell Physiol. 2011 Dec;226(12):3303-15. doi: 10.1002/jcp.22676. PubMed
Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition. Aisagbonhi O, Rai M, Ryzhov S, Atria N, Feoktistov I, Hatzopoulos AK. Dis Model Mech. 2011 Jul;4(4):469-83. doi: 10.1242/dmm.006510. Epub 2011 Feb 14. PubMed
Trenbolone enhances myogenic differentiation by enhancing beta-catenin signaling in muscle-derived stem cells of cattle. Zhao JX, Hu J, Zhu MJ, Du M. Domest Anim Endocrinol. 2011 May;40(4):222-9. doi: 10.1016/j.domaniend.2011.01.004. Epub 2011 Feb 26. PubMed
Methylation and loss of Secreted Frizzled-Related Protein 3 enhances melanoma cell migration and invasion. Ekstrom EJ, Sherwood V, Andersson T. PLoS One. 2011 Apr 8;6(4):e18674. doi: 10.1371/journal.pone.0018674. PubMed
Negative cross-talk between calcium-sensing receptor and beta-catenin signaling systems in colonic epithelium. Rey O, Chang W, Bikle D, Rozengurt N, Young SH, Rozengurt E. J Biol Chem. 2012 Jan 6;287(2):1158-67. doi: 10.1074/jbc.M111.274589. Epub 2011 Nov 17. PubMed
Modulation of Wnt/beta-catenin signaling in human embryonic stem cells using a 3-D microwell array. Azarin SM, Lian X, Larson EA, Popelka HM, de Pablo JJ, Palecek SP. Biomaterials. 2012 Mar;33(7):2041-9. Epub 2011 Dec 15. PubMed

Associated Plasmids

RUNX3-mediated transcriptional inhibition of Akt suppresses tumorigenesis of human gastric cancer cells. Lin FC, Liu YP, Lai CH, Shan YS, Cheng HC, Hsu PI, Lee CH, Lee YC, Wang HY, Wang CH, Cheng JQ, Hsiao M, Lu PJ. Oncogene. 2012 Sep 27;31(39):4302-16. doi: 10.1038/onc.2011.596. Epub 2012 Jan 9. PubMed
Aging brain microenvironment decreases hippocampal neurogenesis through Wnt-mediated survivin signaling. Miranda CJ, Braun L, Jiang Y, Hester ME, Zhang L, Riolo M, Wang H, Rao M, Altura RA, Kaspar BK. Aging Cell. 2012 Jun;11(3):542-52. doi: 10.1111/j.1474-9726.2012.00816.x. Epub 2012 Apr 4. PubMed
The clock gene, brain and muscle Arnt-like 1, regulates adipogenesis via Wnt signaling pathway. Guo B, Chatterjee S, Li L, Kim JM, Lee J, Yechoor VK, Minze LJ, Hsueh W, Ma K. FASEB J. 2012 Aug;26(8):3453-63. doi: 10.1096/fj.12-205781. Epub 2012 May 18. PubMed
The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate beta-catenin signaling. Borgal L, Habbig S, Hatzold J, Liebau MC, Dafinger C, Sacarea I, Hammerschmidt M, Benzing T, Schermer B. J Biol Chem. 2012 Jul 20;287(30):25370-80. doi: 10.1074/jbc.M112.385658. Epub 2012 May 31. PubMed
mrhl RNA, a long noncoding RNA, negatively regulates Wnt signaling through its protein partner Ddx5/p68 in mouse spermatogonial cells. Arun G, Akhade VS, Donakonda S, Rao MR. Mol Cell Biol. 2012 Aug;32(15):3140-52. doi: 10.1128/MCB.00006-12. Epub 2012 Jun 4. PubMed
Glycogen synthase kinase 3 (GSK3) inhibitor, SB-216763, promotes pluripotency in mouse embryonic stem cells. Kirby LA, Schott JT, Noble BL, Mendez DC, Caseley PS, Peterson SC, Routledge TJ, Patel NV. PLoS One. 2012;7(6):e39329. doi: 10.1371/journal.pone.0039329. Epub 2012 Jun 26. PubMed
StearoylCoA desaturase-5: a novel regulator of neuronal cell proliferation and differentiation. Sinner DI, Kim GJ, Henderson GC, Igal RA. PLoS One. 2012;7(6):e39787. doi: 10.1371/journal.pone.0039787. Epub 2012 Jun 22. PubMed
Snf1-related kinase inhibits colon cancer cell proliferation through calcyclin-binding protein-dependent reduction of beta-catenin. Rines AK, Burke MA, Fernandez RP, Volpert OV, Ardehali H. FASEB J. 2012 Nov;26(11):4685-95. doi: 10.1096/fj.12-212282. Epub 2012 Aug 8. PubMed
The (pro)renin receptor ((P)RR) can act as a repressor of Wnt signalling. Bernhard SM, Seidel K, Schmitz J, Klare S, Kirsch S, Schrezenmeier E, Zaade D, Meyborg H, Goldin-Lang P, Stawowy P, Zollmann FS, Unger T, Funke-Kaiser H. Biochem Pharmacol. 2012 Dec 15;84(12):1643-50. doi: 10.1016/j.bcp.2012.09.020. Epub 2012 Sep 26. PubMed
Lithium rescues synaptic plasticity and memory in Down syndrome mice. Contestabile A, Greco B, Ghezzi D, Tucci V, Benfenati F, Gasparini L. J Clin Invest. 2013 Jan;123(1):348-61. doi: 10.1172/JCI64650. Epub 2012 Dec 3. PubMed
Wnt/beta-catenin pathway is regulated by PITX2 homeodomain protein and thus contributes to the proliferation of human ovarian adenocarcinoma cell, SKOV-3. Basu M, Roy SS. J Biol Chem. 2013 Feb 8;288(6):4355-67. doi: 10.1074/jbc.M112.409102. Epub 2012 Dec 17. PubMed
Fanconi anemia proteins interact with CtBP1 and modulate the expression of the Wnt antagonist Dickkopf-1. Huard CC, Tremblay CS, Helsper K, Delisle MC, Schindler D, Levesque G, Carreau M. Blood. 2013 Mar 7;121(10):1729-39. doi: 10.1182/blood-2012-02-408997. Epub 2013 Jan 9. PubMed
SOX9 regulates low density lipoprotein receptor-related protein 6 (LRP6) and T-cell factor 4 (TCF4) expression and Wnt/beta-catenin activation in breast cancer. Wang H, He L, Ma F, Regan MM, Balk SP, Richardson AL, Yuan X. J Biol Chem. 2013 Mar 1;288(9):6478-87. doi: 10.1074/jbc.M112.419184. Epub 2013 Jan 10. PubMed
Regeneration-associated WNT signaling is activated in long-term reconstituting AC133bright acute myeloid leukemia cells. Beghini A, Corlazzoli F, Del Giacco L, Re M, Lazzaroni F, Brioschi M, Valentini G, Ferrazzi F, Ghilardi A, Righi M, Turrini M, Mignardi M, Cesana C, Bronte V, Nilsson M, Morra E, Cairoli R. Neoplasia. 2012 Dec;14(12):1236-48. PubMed
SOX15 is a candidate tumor suppressor in pancreatic cancer with a potential role in Wnt/beta-catenin signaling. Thu KL, Radulovich N, Becker-Santos DD, Pikor LA, Pusic A, Lockwood WW, Lam WL, Tsao MS. Oncogene. 2014 Jan 16;33(3):279-88. doi: 10.1038/onc.2012.595. Epub 2013 Jan 14. PubMed
Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target. Verjee LS, Verhoekx JS, Chan JK, Krausgruber T, Nicolaidou V, Izadi D, Davidson D, Feldmann M, Midwood KS, Nanchahal J. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):E928-37. doi: 10.1073/pnas.1301100110. Epub 2013 Feb 19. PubMed
Androgen activates beta-catenin signaling in bladder cancer cells. Li Y, Zheng Y, Izumi K, Ishiguro H, Ye B, Li F, Miyamoto H. Endocr Relat Cancer. 2013 May 20;20(3):293-304. doi: 10.1530/ERC-12-0328. Print 2013 Jun. PubMed
Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened. Gorojankina T, Hoch L, Faure H, Roudaut H, Traiffort E, Schoenfelder A, Girard N, Mann A, Manetti F, Solinas A, Petricci E, Taddei M, Ruat M. Mol Pharmacol. 2013 May;83(5):1020-9. doi: 10.1124/mol.112.084590. Epub 2013 Feb 28. PubMed
Zinc protoporphyrin suppresses cancer cell viability through a heme oxygenase-1-independent mechanism: the involvement of the Wnt/beta-catenin signaling pathway. Wang S, Avery JE, Hannafon BN, Lind SE, Ding WQ. Biochem Pharmacol. 2013 Jun 1;85(11):1611-8. doi: 10.1016/j.bcp.2013.03.011. Epub 2013 Mar 21. PubMed
Agonism of Wnt-beta-catenin signalling promotes mesenchymal stem cell (MSC) expansion. Hoffman MD, Benoit DS. J Tissue Eng Regen Med. 2013 Apr 1. doi: 10.1002/term.1736. PubMed
Foxc2 induces Wnt4 and Bmp4 expression during muscle regeneration and osteogenesis. Gozo MC, Aspuria PJ, Cheon DJ, Walts AE, Berel D, Miura N, Karlan BY, Orsulic S. Cell Death Differ. 2013 Aug;20(8):1031-42. doi: 10.1038/cdd.2013.34. Epub 2013 May 3. PubMed
Tumor necrosis factor alpha-induced hypoxia-inducible factor 1alpha-beta-catenin axis regulates major histocompatibility complex class I gene activation through chromatin remodeling. Ghosh S, Paul A, Sen E. Mol Cell Biol. 2013 Jul;33(14):2718-31. doi: 10.1128/MCB.01254-12. Epub 2013 May 13. PubMed
Genome-wide RNAi screen reveals a new role of a WNT/CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses. Baril M, Es-Saad S, Chatel-Chaix L, Fink K, Pham T, Raymond VA, Audette K, Guenier AS, Duchaine J, Servant M, Bilodeau M, Cohen E, Grandvaux N, Lamarre D. PLoS Pathog. 2013;9(6):e1003416. doi: 10.1371/journal.ppat.1003416. Epub 2013 Jun 13. PubMed
KLF8 and FAK cooperatively enrich the active MMP14 on the cell surface required for the metastatic progression of breast cancer. Lu H, Hu L, Yu L, Wang X, Urvalek AM, Li T, Shen C, Mukherjee D, Lahiri SK, Wason MS, Zhao J. Oncogene. 2014 May 29;33(22):2909-17. doi: 10.1038/onc.2013.247. Epub 2013 Jul 1. PubMed
MicroRNA-based discovery of barriers to dedifferentiation of fibroblasts to pluripotent stem cells. Judson RL, Greve TS, Parchem RJ, Blelloch R. Nat Struct Mol Biol. 2013 Oct;20(10):1227-35. doi: 10.1038/nsmb.2665. Epub 2013 Sep 15. PubMed
WNT5A encodes two isoforms with distinct functions in cancers. Bauer M, Benard J, Gaasterland T, Willert K, Cappellen D. PLoS One. 2013 Nov 18;8(11):e80526. doi: 10.1371/journal.pone.0080526. eCollection 2013. PubMed
DKK1 promotes hepatocellular carcinoma cell migration and invasion through beta-catenin/MMP7 signaling pathway. Chen L, Li M, Li Q, Wang CJ, Xie SQ. Mol Cancer. 2013 Dec 10;12:157. doi: 10.1186/1476-4598-12-157. PubMed
Anti-leprosy drug clofazimine inhibits growth of triple-negative breast cancer cells via inhibition of canonical Wnt signaling. Koval AV, Vlasov P, Shichkova P, Khunderyakova S, Markov Y, Panchenko J, Volodina A, Kondrashov FA, Katanaev VL. Biochem Pharmacol. 2014 Feb 15;87(4):571-8. doi: 10.1016/j.bcp.2013.12.007. Epub 2013 Dec 16. PubMed
The Fanconi anemia pathway has a dual function in Dickkopf-1 transcriptional repression. Huard CC, Tremblay CS, Magron A, Levesque G, Carreau M. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2152-7. doi: 10.1073/pnas.1314226111. Epub 2014 Jan 27. PubMed
Preclinical activity of the oral proteasome inhibitor MLN9708 in Myeloma bone disease. Garcia-Gomez A, Quwaider D, Canavese M, Ocio EM, Tian Z, Blanco JF, Berger AJ, Ortiz-de-Solorzano C, Hernandez-Iglesias T, Martens AC, Groen RW, Mateo-Urdiales J, Fraile S, Galarraga M, Chauhan D, San Miguel JF, Raje N, Garayoa M. Clin Cancer Res. 2014 Mar 15;20(6):1542-54. doi: 10.1158/1078-0432.CCR-13-1657. Epub 2014 Jan 31. PubMed
Loss of FTO antagonises Wnt signaling and leads to developmental defects associated with ciliopathies. Osborn DP, Roccasecca RM, McMurray F, Hernandez-Hernandez V, Mukherjee S, Barroso I, Stemple D, Cox R, Beales PL, Christou-Savina S. PLoS One. 2014 Feb 4;9(2):e87662. doi: 10.1371/journal.pone.0087662. eCollection 2014. PubMed
Modulating and measuring Wingless signalling. Vincent JP. Methods. 2014 Jun 15;68(1):194-8. doi: 10.1016/j.ymeth.2014.03.015. Epub 2014 Mar 25. PubMed
High-resolution chromatin immunoprecipitation (ChIP) sequencing reveals novel binding targets and prognostic role for SOX11 in mantle cell lymphoma. Kuo PY, Leshchenko VV, Fazzari MJ, Perumal D, Gellen T, He T, Iqbal J, Baumgartner-Wennerholm S, Nygren L, Zhang F, Zhang W, Suh KS, Goy A, Yang DT, Chan WC, Kahl BS, Verma AK, Gascoyne RD, Kimby E, Sander B, Ye BH, Melnick AM, Parekh S. Oncogene. 2015 Mar 5;34(10):1231-40. doi: 10.1038/onc.2014.44. Epub 2014 Mar 31. PubMed
Barx2 and Pax7 have antagonistic functions in regulation of wnt signaling and satellite cell differentiation. Zhuang L, Hulin JA, Gromova A, Tran Nguyen TD, Yu RT, Liddle C, Downes M, Evans RM, Makarenkova HP, Meech R. Stem Cells. 2014 Jun;32(6):1661-73. doi: 10.1002/stem.1674. PubMed
MiR-29b downregulates canonical Wnt signaling by suppressing coactivators of beta-catenin in human colorectal cancer cells. Subramanian M, Rao SR, Thacker P, Chatterjee S, Karunagaran D. J Cell Biochem. 2014 Nov;115(11):1974-84. doi: 10.1002/jcb.24869. PubMed
Pax6 regulates the expression of Dkk3 in murine and human cell lines, and altered responses to Wnt signaling are shown in FlpIn-3T3 cells stably expressing either the Pax6 or the Pax6(5a) isoform. Forsdahl S, Kiselev Y, Hogseth R, Mjelle JE, Mikkola I. PLoS One. 2014 Jul 16;9(7):e102559. doi: 10.1371/journal.pone.0102559. eCollection 2014. PubMed
Casein kinase 1 alpha phosphorylates the Wnt regulator Jade-1 and modulates its activity. Borgal L, Rinschen MM, Dafinger C, Hoff S, Reinert MJ, Lamkemeyer T, Lienkamp SS, Benzing T, Schermer B. J Biol Chem. 2014 Sep 19;289(38):26344-56. doi: 10.1074/jbc.M114.562165. Epub 2014 Aug 6. PubMed
Pin1 positively affects tumorigenesis of esophageal squamous cell carcinoma and correlates with poor survival of patients. Lin FC, Lee YC, Goan YG, Tsai CH, Yao YC, Cheng HC, Lai WW, Wang YC, Sheu BS, Lu PJ. J Biomed Sci. 2014 Aug 27;21:75. doi: 10.1186/s12929-014-0075-1. PubMed
Tenascin-C is required for normal Wnt/beta-catenin signaling in the whisker follicle stem cell niche. Hendaoui I, Tucker RP, Zingg D, Bichet S, Schittny J, Chiquet-Ehrismann R. Matrix Biol. 2014 Nov;40:46-53. doi: 10.1016/j.matbio.2014.08.017. Epub 2014 Sep 6. PubMed
Emodin suppresses Wnt signaling in human colorectal cancer cells SW480 and SW620. Pooja T, Karunagaran D. Eur J Pharmacol. 2014 Nov 5;742:55-64. doi: 10.1016/j.ejphar.2014.08.028. Epub 2014 Sep 6. PubMed
CD44 functions in Wnt signaling by regulating LRP6 localization and activation. Schmitt M, Metzger M, Gradl D, Davidson G, Orian-Rousseau V. Cell Death Differ. 2015 Apr;22(4):677-89. doi: 10.1038/cdd.2014.156. Epub 2014 Oct 10. PubMed
RHOA inactivation enhances Wnt signalling and promotes colorectal cancer. Rodrigues P, Macaya I, Bazzocco S, Mazzolini R, Andretta E, Dopeso H, Mateo-Lozano S, Bilic J, Carton-Garcia F, Nieto R, Suarez-Lopez L, Afonso E, Landolfi S, Hernandez-Losa J, Kobayashi K, Ramon y Cajal S, Tabernero J, Tebbutt NC, Mariadason JM, Schwartz S Jr, Arango D. Nat Commun. 2014 Nov 21;5:5458. doi: 10.1038/ncomms6458. PubMed
MicroRNA-214 controls skin and hair follicle development by modulating the activity of the Wnt pathway. Ahmed MI, Alam M, Emelianov VU, Poterlowicz K, Patel A, Sharov AA, Mardaryev AN, Botchkareva NV. J Cell Biol. 2014 Nov 24;207(4):549-67. doi: 10.1083/jcb.201404001. PubMed
Fezf2 promotes neuronal differentiation through localised activation of Wnt/beta-catenin signalling during forebrain development. Zhang S, Li J, Lea R, Vleminckx K, Amaya E. Development. 2014 Dec;141(24):4794-805. doi: 10.1242/dev.115691. PubMed
Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the Caspase-dependent degradation of AKT. Bisson JA, Mills B, Paul Helt JC, Zwaka TP, Cohen ED. Dev Biol. 2015 Feb 1;398(1):80-96. doi: 10.1016/j.ydbio.2014.11.015. Epub 2014 Dec 5. PubMed
Inhibition of mesothelioma cancer stem-like cells with adenovirus-mediated NK4 gene therapy. Deng XB, Xiao L, Wu Y, Jin F, Mossman B, Testa JR, Xiao GH. Int J Cancer. 2015 Jul 15;137(2):481-90. doi: 10.1002/ijc.29391. Epub 2014 Dec 27. PubMed
Disruption of cell-cell contact-mediated notch signaling via hydrogel encapsulation reduces mesenchymal stem cell chondrogenic potential: winner of the Society for Biomaterials Student Award in the Undergraduate Category, Charlotte, NC, April 15 to 18, 2015. Chen AX, Hoffman MD, Chen CS, Shubin AD, Reynolds DS, Benoit DS. J Biomed Mater Res A. 2015 Apr;103(4):1291-302. doi: 10.1002/jbm.a.35383. Epub 2014 Dec 31. PubMed
Dose-dependent nuclear beta-catenin response segregates endomesoderm along the sea star primary axis. McCauley BS, Akyar E, Saad HR, Hinman VF. Development. 2015 Jan 1;142(1):207-17. doi: 10.1242/dev.113043. PubMed
Paired related homeobox 1 is associated with the invasive properties of glioblastoma cells. Sugiyama M, Hasegawa H, Ito S, Sugiyama K, Maeda M, Aoki K, Wakabayashi T, Hamaguchi M, Natsume A, Senga T. Oncol Rep. 2015 Mar;33(3):1123-30. doi: 10.3892/or.2014.3681. Epub 2014 Dec 18. PubMed
Renal developmental defects resulting from in utero hypoxia are associated with suppression of ureteric beta-catenin signaling. Wilkinson LJ, Neal CS, Singh RR, Sparrow DB, Kurniawan ND, Ju A, Grieve SM, Dunwoodie SL, Moritz KM, Little MH. Kidney Int. 2015 May;87(5):975-83. doi: 10.1038/ki.2014.394. Epub 2015 Jan 14. PubMed
Identification of therapeutic small-molecule leads in cultured cells using multiplexed pathway reporter readouts. Kulak O, Yamaguchi K, Lum L. Methods Mol Biol. 2015;1263:3-14. doi: 10.1007/978-1-4939-2269-7_1. PubMed
RSPO2 Enhances Canonical Wnt Signaling to Confer Stemness-Associated Traits to Susceptible Pancreatic Cancer Cells. Ilmer M, Boiles AR, Regel I, Yokoi K, Michalski CW, Wistuba II, Rodriguez J, Alt E, Vykoukal J. Cancer Res. 2015 May 1;75(9):1883-96. doi: 10.1158/0008-5472.CAN-14-1327. Epub 2015 Mar 13. PubMed
Transformation of the intestinal epithelium by the MSI2 RNA-binding protein. Wang S, Li N, Yousefi M, Nakauka-Ddamba A, Li F, Parada K, Rao S, Minuesa G, Katz Y, Gregory BD, Kharas MG, Yu Z, Lengner CJ. Nat Commun. 2015 Mar 16;6:6517. doi: 10.1038/ncomms7517. PubMed
Curcumin and emodin down-regulate TGF-beta signaling pathway in human cervical cancer cells. Thacker PC, Karunagaran D. PLoS One. 2015 Mar 18;10(3):e0120045. doi: 10.1371/journal.pone.0120045. eCollection 2015. PubMed
Targeting the neurokinin-1 receptor inhibits growth of human colon cancer cells. Garnier A, Vykoukal J, Hubertus J, Alt E, von Schweinitz D, Kappler R, Berger M, Ilmer M. Int J Oncol. 2015 Jul;47(1):151-60. doi: 10.3892/ijo.2015.3016. Epub 2015 May 21. PubMed
An IkappaB Kinase-Regulated Feedforward Circuit Prolongs Inflammation. Perez JM, Chirieleison SM, Abbott DW. Cell Rep. 2015 Jul 28;12(4):537-44. doi: 10.1016/j.celrep.2015.06.050. Epub 2015 Jul 16. PubMed
beta-Catenin destruction complex-independent regulation of Hippo-YAP signaling by APC in intestinal tumorigenesis. Cai J, Maitra A, Anders RA, Taketo MM, Pan D. Genes Dev. 2015 Jul 15;29(14):1493-506. doi: 10.1101/gad.264515.115. Epub 2015 Jul 20. PubMed
Angiotensin II prevents calcification in vascular smooth muscle cells by enhancing magnesium influx. Herencia C, Rodriguez-Ortiz ME, Munoz-Castaneda JR, Martinez-Moreno JM, Canalejo R, Montes de Oca A, Diaz-Tocados JM, Peralbo-Santaella E, Marin C, Canalejo A, Rodriguez M, Almaden Y. Eur J Clin Invest. 2015 Nov;45(11):1129-44. doi: 10.1111/eci.12517. Epub 2015 Sep 13. PubMed
Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion. Elsarraj HS, Hong Y, Valdez KE, Michaels W, Hook M, Smith WP, Chien J, Herschkowitz JI, Troester MA, Beck M, Inciardi M, Gatewood J, May L, Cusick T, McGinness M, Ricci L, Fan F, Tawfik O, Marks JR, Knapp JR, Yeh HW, Thomas P, Carrasco DR, Fields TA, Godwin AK, Behbod F. Breast Cancer Res. 2015 Sep 17;17:128. doi: 10.1186/s13058-015-0630-z. PubMed
MicroRNA-1 down-regulates proliferation and migration of breast cancer stem cells by inhibiting the Wnt/beta-catenin pathway. Liu T, Hu K, Zhao Z, Chen G, Ou X, Zhang H, Zhang X, Wei X, Wang D, Cui M, Liu C. Oncotarget. 2015 Dec 8;6(39):41638-49. doi: 10.18632/oncotarget.5873. PubMed
Targeting the Neurokinin-1 Receptor Compromises Canonical Wnt Signaling in Hepatoblastoma. Ilmer M, Garnier A, Vykoukal J, Alt E, von Schweinitz D, Kappler R, Berger M. Mol Cancer Ther. 2015 Dec;14(12):2712-21. doi: 10.1158/1535-7163.MCT-15-0206. Epub 2015 Oct 29. PubMed
The canonical Wnt pathway regulates the metastasis-promoting mucin MUC4 in pancreatic ductal adenocarcinoma. Pai P, Rachagani S, Lakshmanan I, Macha MA, Sheinin Y, Smith LM, Ponnusamy MP, Batra SK. Mol Oncol. 2016 Feb;10(2):224-39. doi: 10.1016/j.molonc.2015.10.005. Epub 2015 Oct 19. PubMed
Comprehensive functional characterization of cancer-testis antigens defines obligate participation in multiple hallmarks of cancer. Maxfield KE, Taus PJ, Corcoran K, Wooten J, Macion J, Zhou Y, Borromeo M, Kollipara RK, Yan J, Xie Y, Xie XJ, Whitehurst AW. Nat Commun. 2015 Nov 16;6:8840. doi: 10.1038/ncomms9840. PubMed
Wnt/beta-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance. Wickstrom M, Dyberg C, Milosevic J, Einvik C, Calero R, Sveinbjornsson B, Sanden E, Darabi A, Siesjo P, Kool M, Kogner P, Baryawno N, Johnsen JI. Nat Commun. 2015 Nov 25;6:8904. doi: 10.1038/ncomms9904. PubMed
beta-Catenin, a Transcription Factor Activated by Canonical Wnt Signaling, Is Expressed in Sensory Neurons of Calves Latently Infected with Bovine Herpesvirus 1. Liu Y, Hancock M, Workman A, Doster A, Jones C. J Virol. 2016 Jan 6;90(6):3148-59. doi: 10.1128/JVI.02971-15. PubMed
Identification of DPY19L3 as the C-mannosyltransferase of R-spondin1 in human cells. Niwa Y, Suzuki T, Dohmae N, Simizu S. Mol Biol Cell. 2016 Jan 13. pii: mbc.E15-06-0373. PubMed
Prenatal beta-catenin/Brn2/Tbr2 transcriptional cascade regulates adult social and stereotypic behaviors. Belinson H, Nakatani J, Babineau BA, Birnbaum RY, Ellegood J, Bershteyn M, McEvilly RJ, Long JM, Willert K, Klein OD, Ahituv N, Lerch JP, Rosenfeld MG, Wynshaw-Boris A. Mol Psychiatry. 2016 Feb 2. doi: 10.1038/mp.2015.207. PubMed
Biphasic modulation of Wnt signaling supports efficient foregut endoderm formation from human pluripotent stem cells. Hoepfner J, Kleinsorge M, Papp O, Ackermann M, Alfken S, Rinas U, Solodenko W, Kirschning A, Sgodda M, Cantz T. Cell Biol Int. 2016 May;40(5):534-48. doi: 10.1002/cbin.10590. Epub 2016 Feb 25. PubMed
The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesis. Leow SC, Poschmann J, Too PG, Yin J, Joseph R, McFarlane C, Dogra S, Shabbir A, Ingham PW, Prabhakar S, Leow MK, Lee YS, Ng KL, Chong YS, Gluckman PD, Stunkel W. Development. 2016 Mar 15;143(6):950-61. doi: 10.1242/dev.131573. Epub 2016 Feb 18. PubMed
Identification of Novel Candidate Genes for Early-Onset Colorectal Cancer Susceptibility. de Voer RM, Hahn MM, Weren RD, Mensenkamp AR, Gilissen C, van Zelst-Stams WA, Spruijt L, Kets CM, Zhang J, Venselaar H, Vreede L, Schubert N, Tychon M, Derks R, Schackert HK, Geurts van Kessel A, Hoogerbrugge N, Ligtenberg MJ, Kuiper RP. PLoS Genet. 2016 Feb 22;12(2):e1005880. doi: 10.1371/journal.pgen.1005880. eCollection 2016 Feb. PubMed
Synergistic role of beta-catenin1 and 2 in ovarian differentiation and maintenance of female pathway in Nile tilapia. Wu L, Wu F, Xie L, Wang D, Zhou L. Mol Cell Endocrinol. 2016 May 15;427:33-44. doi: 10.1016/j.mce.2016.03.002. Epub 2016 Mar 4. PubMed
An Epigenetic Reprogramming Strategy to Resensitize Radioresistant Prostate Cancer Cells. Peitzsch C, Cojoc M, Hein L, Kurth I, Mabert K, Trautmann F, Klink B, Schrock E, Wirth MP, Krause M, Stakhovsky EA, Telegeev GD, Novotny V, Toma M, Muders M, Baretton GB, Frame FM, Maitland NJ, Baumann M, Dubrovska A. Cancer Res. 2016 May 1;76(9):2637-51. doi: 10.1158/0008-5472.CAN-15-2116. Epub 2016 Mar 16. PubMed
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MicroRNA-29 impairs the early phase of reprogramming process by targeting active DNA demethylation enzymes and Wnt signaling. Fraguas MS, Eggenschwiler R, Hoepfner J, Schiavinato JL, Haddad R, Oliveira LH, Araujo AG, Zago MA, Panepucci RA, Cantz T. Stem Cell Res. 2016 Dec 19;19:21-30. doi: 10.1016/j.scr.2016.12.020. PubMed
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A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma. Tammela T, Sanchez-Rivera FJ, Cetinbas NM, Wu K, Joshi NS, Helenius K, Park Y, Azimi R, Kerper NR, Wesselhoeft RA, Gu X, Schmidt L, Cornwall-Brady M, Yilmaz OH, Xue W, Katajisto P, Bhutkar A, Jacks T. Nature. 2017 May 18;545(7654):355-359. doi: 10.1038/nature22334. Epub 2017 May 10. PubMed
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Genetic analysis of Wnt/PCP genes in neural tube defects. Chen Z, Lei Y, Cao X, Zheng Y, Wang F, Bao Y, Peng R, Finnell RH, Zhang T, Wang H. BMC Med Genomics. 2018 Apr 4;11(1):38. doi: 10.1186/s12920-018-0355-9. PubMed
MicroRNA-26a is a key regulon that inhibits progression and metastasis of c-Myc/EZH2 double high advanced hepatocellular carcinoma. Zhang X, Zhang X, Wang T, Wang L, Tan Z, Wei W, Yan B, Zhao J, Wu K, Yang A, Zhang R, Jia L. Cancer Lett. 2018 Jul 10;426:98-108. doi: 10.1016/j.canlet.2018.04.005. Epub 2018 Apr 11. PubMed
Promotion of malignant phenotype after disruption of the three-dimensional structure of cultured spheroids from colorectal cancer. Piulats JM, Kondo J, Endo H, Ono H, Hagihara T, Okuyama H, Nishizawa Y, Tomita Y, Ohue M, Okita K, Oyama H, Bono H, Masuko T, Inoue M. Oncotarget. 2018 Mar 23;9(22):15968-15983. doi: 10.18632/oncotarget.24641. eCollection 2018 Mar 23. PubMed
SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling via Transcriptional and Posttranslational Regulation of beta-Catenin in Lung Cancer. Han F, Liu WB, Shi XY, Yang JT, Zhang X, Li ZM, Jiang X, Yin L, Li JJ, Huang CS, Cao J, Liu JY. EBioMedicine. 2018 May;31:253-266. doi: 10.1016/j.ebiom.2018.04.026. Epub 2018 May 5. PubMed
An In Vivo Screen Identifies PYGO2 as a Driver for Metastatic Prostate Cancer. Lu X, Pan X, Wu CJ, Zhao D, Feng S, Zang Y, Lee R, Khadka S, Amin SB, Jin EJ, Shang X, Deng P, Luo Y, Morgenlander WR, Weinrich J, Lu X, Jiang S, Chang Q, Navone NM, Troncoso P, DePinho RA, Wang YA. Cancer Res. 2018 Jul 15;78(14):3823-3833. doi: 10.1158/0008-5472.CAN-17-3564. Epub 2018 May 16. PubMed
Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner. Lee Y, Kim NH, Cho ES, Yang JH, Cha YH, Kang HE, Yun JS, Cho SB, Lee SH, Paclikova P, Radaszkiewicz TW, Bryja V, Kang CG, Yuk YS, Cha SY, Kim SY, Kim HS, Yook JI. Nat Commun. 2018 Jun 12;9(1):2301. doi: 10.1038/s41467-018-04757-w. PubMed
A molecular mechanism for Wnt ligand-specific signaling. Eubelen M, Bostaille N, Cabochette P, Gauquier A, Tebabi P, Dumitru AC, Koehler M, Gut P, Alsteens D, Stainier DYR, Garcia-Pino A, Vanhollebeke B. Science. 2018 Aug 17;361(6403). pii: science.aat1178. doi: 10.1126/science.aat1178. Epub 2018 Jul 19. PubMed
The canonical Wnt/beta-catenin signaling pathway stimulates herpes simplex virus 1 productive infection. Zhu L, Jones C. Virus Res. 2018 Sep 2;256:29-37. doi: 10.1016/j.virusres.2018.07.020. Epub 2018 Aug 2. PubMed
JARID2 and the PRC2 complex regulate skeletal muscle differentiation through regulation of canonical Wnt signaling. Adhikari A, Davie J. Epigenetics Chromatin. 2018 Aug 17;11(1):46. doi: 10.1186/s13072-018-0217-x. PubMed
Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia. Lee SH, Singh I, Tisdale S, Abdel-Wahab O, Leslie CS, Mayr C. Nature. 2018 Sep;561(7721):127-131. doi: 10.1038/s41586-018-0465-8. Epub 2018 Aug 27. PubMed
Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer. Wagner AH, Devarakonda S, Skidmore ZL, Krysiak K, Ramu A, Trani L, Kunisaki J, Masood A, Waqar SN, Spies NC, Morgensztern D, Waligorski J, Ponce J, Fulton RS, Maggi LB Jr, Weber JD, Watson MA, O'Conor CJ, Ritter JH, Olsen RR, Cheng H, Mukhopadhyay A, Can I, Cessna MH, Oliver TG, Mardis ER, Wilson RK, Griffith M, Griffith OL, Govindan R. Nat Commun. 2018 Sep 17;9(1):3787. doi: 10.1038/s41467-018-06162-9. PubMed
Combined Proteomic and In Silico Target Identification Reveal a Role for 5-Lipoxygenase in Developmental Signaling Pathways. Brand S, Roy S, Schroder P, Rathmer B, Roos J, Kapoor S, Patil S, Pommerenke C, Maier T, Janning P, Eberth S, Steinhilber D, Schade D, Schneider G, Kumar K, Ziegler S, Waldmann H. Cell Chem Biol. 2018 Sep 20;25(9):1095-1106.e23. doi: 10.1016/j.chembiol.2018.05.016. Epub 2018 Jun 28. PubMed
Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes beta-catenin. Kim J, Alavi Naini F, Sun Y, Ma L. Am J Cancer Res. 2018 Sep 1;8(9):1823-1836. eCollection 2018. PubMed
Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/beta-Catenin Signaling. Cha B, Geng X, Mahamud MR, Zhang JY, Chen L, Kim W, Jho EH, Kim Y, Choi D, Dixon JB, Chen H, Hong YK, Olson L, Kim TH, Merrill BJ, Davis MJ, Srinivasan RS. Cell Rep. 2018 Oct 16;25(3):571-584.e5. doi: 10.1016/j.celrep.2018.09.049. PubMed
Expression of the Hutchinson-Gilford Progeria Mutation Leads to Aberrant Dentin Formation. Choi H, Kim TH, Jeong JK, Strandgren C, Eriksson M, Cho ES. Sci Rep. 2018 Oct 18;8(1):15368. doi: 10.1038/s41598-018-33764-6. PubMed
Clotrimazole inhibits the Wnt/beta-catenin pathway by activating two eIF2alpha kinases: The heme-regulated translational inhibitor and the double-stranded RNA-induced protein kinase. Yonezawa H, Ogawa M, Katayama S, Shimizu Y, Omori N, Oku Y, Sakyo T, Uehara Y, Nishiya N. Biochem Biophys Res Commun. 2018 Nov 17;506(1):183-188. doi: 10.1016/j.bbrc.2018.10.053. Epub 2018 Oct 17. PubMed
Chromomycin A2 potently inhibits glucose-stimulated insulin secretion from pancreatic beta cells. Kalwat MA, Hwang IH, Macho J, Grzemska MG, Yang JZ, McGlynn K, MacMillan JB, Cobb MH. J Gen Physiol. 2018 Dec 3;150(12):1747-1757. doi: 10.1085/jgp.201812177. Epub 2018 Oct 23. PubMed
SLIT3 regulates endochondral ossification by beta-catenin suppression in chondrocytes. Kim H, Choi YJ, Lee YS, Park SY, Baek JE, Kim HK, Kim BJ, Lee SH, Koh JM. Biochem Biophys Res Commun. 2018 Dec 2;506(4):847-853. doi: 10.1016/j.bbrc.2018.10.167. Epub 2018 Oct 31. PubMed
Hypoxia Stimulates the Epithelial-to-Mesenchymal Transition in Lung Cancer Cells Through Accumulation of Nuclear beta-Catenin. Liu KH, Tsai YT, Chin SY, Lee WR, Chen YC, Shen SC. Anticancer Res. 2018 Nov;38(11):6299-6308. doi: 10.21873/anticanres.12986. PubMed
Oncogenic potential of N-terminal deletion and S45Y mutant beta-catenin in promoting hepatocellular carcinoma development in mice. Qiao Y, Xu M, Tao J, Che L, Cigliano A, Monga SP, Calvisi DF, Chen X. BMC Cancer. 2018 Nov 12;18(1):1093. doi: 10.1186/s12885-018-4870-z. PubMed
A Novel Regulatory Axis, CHD1L-MicroRNA 486-Matrix Metalloproteinase 2, Controls Spermatogonial Stem Cell Properties. Liu SS, Maguire EM, Bai YS, Huang L, Liu Y, Xu L, Fauzi I, Zhang SQ, Xiao Q, Ma NF. Mol Cell Biol. 2019 Feb 4;39(4). pii: MCB.00357-18. doi: 10.1128/MCB.00357-18. Print 2019 Feb 15. PubMed
Identifying chondroprotective diet-derived bioactives and investigating their synergism. Davidson RK, Green J, Gardner S, Bao Y, Cassidy A, Clark IM. Sci Rep. 2018 Nov 21;8(1):17173. doi: 10.1038/s41598-018-35455-8. PubMed
Cartilage Oligomeric Matrix Protein initiates cancer stem cells through activation of Jagged1-Notch3 signaling. Papadakos KS, Bartoschek M, Rodriguez C, Gialeli C, Jin SB, Lendahl U, Pietras K, Blom AM. Matrix Biol. 2018 Nov 28. pii: S0945-053X(18)30391-3. doi: 10.1016/j.matbio.2018.11.007. PubMed
SOX30 specially prevents Wnt-signaling to suppress metastasis and improve prognosis of lung adenocarcinoma patients. Han F, Zhang MQ, Liu WB, Sun L, Hao XL, Yin L, Jiang X, Cao J, Liu JY. Respir Res. 2018 Dec 4;19(1):241. doi: 10.1186/s12931-018-0952-3. PubMed
Nutritional stress reprograms dedifferention in glioblastoma multiforme driven by PTEN/Wnt/Hedgehog axis: a stochastic model of cancer stem cells. Mondal S, Bhattacharya K, Mandal C. Cell Death Discov. 2018 Dec 5;4:110. doi: 10.1038/s41420-018-0126-6. eCollection 2018. PubMed
Cyclin G2 suppresses Wnt/beta-catenin signaling and inhibits gastric cancer cell growth and migration through Dapper1. Gao J, Zhao C, Liu Q, Hou X, Li S, Xing X, Yang C, Luo Y. J Exp Clin Cancer Res. 2018 Dec 14;37(1):317. doi: 10.1186/s13046-018-0973-2. PubMed
Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells. Brown BA, Connolly GM, Mill CEJ, Williams H, Angelini GD, Johnson JL, George SJ. Aging Cell. 2019 Feb;18(1):e12844. doi: 10.1111/acel.12844. Epub 2018 Dec 12. PubMed
Transcriptome 3'end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma. Ogorodnikov A, Levin M, Tattikota S, Tokalov S, Hoque M, Scherzinger D, Marini F, Poetsch A, Binder H, Macher-Goppinger S, Probst HC, Tian B, Schaefer M, Lackner KJ, Westermann F, Danckwardt S. Nat Commun. 2018 Dec 14;9(1):5331. doi: 10.1038/s41467-018-07580-5. PubMed
(Pro)renin receptor promotes colorectal cancer through the Wnt/beta-catenin signalling pathway despite constitutive pathway component mutations. Wang J, Shibayama Y, Zhang A, Ohsaki H, Asano E, Suzuki Y, Kushida Y, Kobara H, Masaki T, Wang Z, Nishiyama A. Br J Cancer. 2019 Jan;120(2):229-237. doi: 10.1038/s41416-018-0350-0. Epub 2018 Dec 17. PubMed
The Wnt modulator ICG001 mediates the inhibition of nasopharyngeal carcinoma cell migration in vitro via the miR150/CD44 axis. Chan LS, Man OY, Kwok HH, Chen L, Chan KC, Lung HL, Ngan RK, Wong RN, Lo KW, Lee AW, Tsao GS, Kahn M, Lung ML, Mak NK. Int J Oncol. 2019 Mar;54(3):1010-1020. doi: 10.3892/ijo.2018.4664. Epub 2018 Dec 12. PubMed
A high-throughput assay pipeline for specific targeting of frizzled GPCRs in cancer. Shaw HV, Koval A, Katanaev VL. Methods Cell Biol. 2019;149:57-75. doi: 10.1016/bs.mcb.2018.08.006. Epub 2018 Sep 17. PubMed
Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts. Ferrari N, Ranftl R, Chicherova I, Slaven ND, Moeendarbary E, Farrugia AJ, Lam M, Semiannikova M, Westergaard MCW, Tchou J, Magnani L, Calvo F. Nat Commun. 2019 Jan 10;10(1):130. doi: 10.1038/s41467-018-07987-0. PubMed
beta-Catenin is essential for differentiation of primary myoblasts via cooperation with MyoD and alpha-catenin. Cui S, Li L, Yu RT, Downes M, Evans RM, Hulin JA, Makarenkova HP, Meech R. Development. 2019 Mar 19;146(6). pii: dev.167080. doi: 10.1242/dev.167080. PubMed
Axis inhibition protein 1 (Axin1) Deletion-Induced Hepatocarcinogenesis Requires Intact beta-Catenin but Not Notch Cascade in Mice. Qiao Y, Wang J, Karagoz E, Liang B, Song X, Shang R, Evert K, Xu M, Che L, Evert M, Calvisi DF, Tao J, Wang B, Monga SP, Chen X. Hepatology. 2019 Feb 8. doi: 10.1002/hep.30556. PubMed
Tryptophan-kynurenine pathway attenuates beta-catenin-dependent pro-parasitic role of STING-TICAM2-IRF3-IDO1 signalosome in Toxoplasma gondii infection. Majumdar T, Sharma S, Kumar M, Hussain MA, Chauhan N, Kalia I, Sahu AK, Rana VS, Bharti R, Haldar AK, Singh AP, Mazumder S. Cell Death Dis. 2019 Feb 15;10(3):161. doi: 10.1038/s41419-019-1420-9. PubMed
Hyaluronan-mediated motility receptor confers resistance to chemotherapy via TGFbeta/Smad2-induced epithelial-mesenchymal transition in gastric cancer. Zhang H, Ren L, Ding Y, Li F, Chen X, Ouyang Y, Zhang Y, Zhang D. FASEB J. 2019 May;33(5):6365-6377. doi: 10.1096/fj.201802186R. Epub 2019 Feb 25. PubMed
Innate extracellular vesicles from melanoma patients suppress beta-catenin in tumor cells by miRNA-34a. Lee JH, Dindorf J, Eberhardt M, Lai X, Ostalecki C, Koliha N, Gross S, Blume K, Bruns H, Wild S, Schuler G, Vera J, Baur AS. Life Sci Alliance. 2019 Mar 7;2(2). pii: 2/2/e201800205. doi: 10.26508/lsa.201800205. Print 2019 Apr. PubMed
RAL GTPases Drive Intestinal Stem Cell Function and Regeneration through Internalization of WNT Signalosomes. Johansson J, Naszai M, Hodder MC, Pickering KA, Miller BW, Ridgway RA, Yu Y, Peschard P, Brachmann S, Campbell AD, Cordero JB, Sansom OJ. Cell Stem Cell. 2019 Apr 4;24(4):592-607.e7. doi: 10.1016/j.stem.2019.02.002. Epub 2019 Mar 7. PubMed
Targeting FER Kinase Inhibits Melanoma Growth and Metastasis. Ivanova IA, Arulanantham S, Barr K, Cepeda M, Parkins KM, Hamilton AM, Johnston D, Penuela S, Hess DA, Ronald JA, Dagnino L. Cancers (Basel). 2019 Mar 24;11(3). pii: cancers11030419. doi: 10.3390/cancers11030419. PubMed
Proton pump inhibitor pantoprazole inhibits gastric cancer metastasis via suppression of telomerase reverse transcriptase gene expression. Zhang B, Ling T, Zhaxi P, Cao Y, Qian L, Zhao D, Kang W, Zhang W, Wang L, Xu G, Zou X. Cancer Lett. 2019 Jun 28;452:23-30. doi: 10.1016/j.canlet.2019.03.029. Epub 2019 Mar 23. PubMed
Identification of two independent SUMO-interacting motifs in Fas-associated factor 1 (FAF1): Implications for mineralocorticoid receptor (MR)-mediated transcriptional regulation. Wang CH, Hung PW, Chiang CW, Lombes M, Chen CH, Lee KH, Lo YC, Wu MH, Chang WC, Lin DY. Biochim Biophys Acta Mol Cell Res. 2019 Aug;1866(8):1282-1297. doi: 10.1016/j.bbamcr.2019.03.014. Epub 2019 Mar 29. PubMed
Cmannosylation of Rspondin2 activates Wnt/betacatenin signaling and migration activity in human tumor cells. Mizuta H, Kuga K, Suzuki T, Niwa Y, Dohmae N, Simizu S. Int J Oncol. 2019 Jun;54(6):2127-2138. doi: 10.3892/ijo.2019.4767. Epub 2019 Apr 1. PubMed
Molecular determinants of WNT9b responsiveness in nephron progenitor cells. Dickinson KK, Hammond LC, Karner CM, Hastie ND, Carroll TJ, Goodyer P. PLoS One. 2019 Apr 12;14(4):e0215139. doi: 10.1371/journal.pone.0215139. eCollection 2019. PubMed
Organoid culture media formulated with growth factors of defined cellular activity. Urbischek M, Rannikmae H, Foets T, Ravn K, Hyvonen M, de la Roche M. Sci Rep. 2019 Apr 17;9(1):6193. doi: 10.1038/s41598-019-42604-0. PubMed

Associated Plasmids

Drug Design and Synthesis of First in Class PDZ1 Targeting NHERF1 Inhibitors as Anticancer Agents. Coluccia A, La Regina G, Naccarato V, Nalli M, Orlando V, Biagioni S, De Angelis ML, Baiocchi M, Gautier C, Gianni S, Di Pastena F, Di Magno L, Canettieri G, Coluccia AML, Silvestri R. ACS Med Chem Lett. 2019 Jan 14;10(4):499-503. doi: 10.1021/acsmedchemlett.8b00532. eCollection 2019 Apr 11. PubMed
Antagonistic interactions between osterix and pyrophosphate during cementum formation. Choi H, Liu Y, Jeong JK, Kim TH, Cho ES. Bone. 2019 Aug;125:8-15. doi: 10.1016/j.bone.2019.05.001. Epub 2019 May 4. PubMed
Downregulated Wnt/beta-catenin signalling in the Down syndrome hippocampus. Granno S, Nixon-Abell J, Berwick DC, Tosh J, Heaton G, Almudimeegh S, Nagda Z, Rain JC, Zanda M, Plagnol V, Tybulewicz VLJ, Cleverley K, Wiseman FK, Fisher EMC, Harvey K. Sci Rep. 2019 May 13;9(1):7322. doi: 10.1038/s41598-019-43820-4. PubMed
Small Heterodimer Partner Controls the Virus-Mediated Antiviral Immune Response by Targeting CREB-Binding Protein in the Nucleus. Kim JH, Yoon JE, Nikapitiya C, Kim TH, Uddin MB, Lee HC, Kim YH, Hwang JH, Chathuranga K, Chathuranga WAG, Choi HS, Kim CJ, Jung JU, Lee CH, Lee JS. Cell Rep. 2019 May 14;27(7):2105-2118.e5. doi: 10.1016/j.celrep.2019.04.071. PubMed
Lithium chloride corrects weakness and myopathology in a preclinical model of LGMD1D. Findlay AR, Bengoechea R, Pittman SK, Chou TF, True HL, Weihl CC. Neurol Genet. 2019 Apr 18;5(2):e318. doi: 10.1212/NXG.0000000000000318. eCollection 2019 Apr. PubMed
Silencing LGR6 Attenuates Stemness and Chemoresistance via Inhibiting Wnt/beta-Catenin Signaling in Ovarian Cancer. Ruan X, Liu A, Zhong M, Wei J, Zhang W, Rong Y, Liu W, Li M, Qing X, Chen G, Li R, Liao Y, Liu Q, Zhang X, Ren D, Wang Y. Mol Ther Oncolytics. 2019 Apr 19;14:94-106. doi: 10.1016/j.omto.2019.04.002. eCollection 2019 Sep 27. PubMed
Piplartine suppresses proliferation and invasion of hepatocellular carcinoma by LINC01391-modulated Wnt/beta-catenin pathway inactivation through ICAT. Fan X, Song J, Zhao Z, Chen M, Tu J, Lu C, Wu F, Zhang D, Weng Q, Zheng L, Xu M, Ji J. Cancer Lett. 2019 Sep 28;460:119-127. doi: 10.1016/j.canlet.2019.06.008. Epub 2019 Jun 14. PubMed
Activation of Wnt signaling promotes olaparib resistant ovarian cancer. Yamamoto TM, McMellen A, Watson ZL, Aguilera J, Ferguson R, Nurmemmedov E, Thakar T, Moldovan GL, Kim H, Cittelly DM, Joglar AM, Brennecke EP, Wilson H, Behbakht K, Sikora MJ, Bitler BG. Mol Carcinog. 2019 Jun 10. doi: 10.1002/mc.23064. PubMed
WNT-3A-induced beta-catenin signaling does not require signaling through heterotrimeric G proteins. Bowin CF, Inoue A, Schulte G. J Biol Chem. 2019 Aug 2;294(31):11677-11684. doi: 10.1074/jbc.AC119.009412. Epub 2019 Jun 24. PubMed
Vitamin K3 (menadione) suppresses epithelial-mesenchymal-transition and Wnt signaling pathway in human colorectal cancer cells. Kishore C, Sundaram S, Karunagaran D. Chem Biol Interact. 2019 Aug 25;309:108725. doi: 10.1016/j.cbi.2019.108725. Epub 2019 Jun 22. PubMed
Exostosin-1 enhances canonical Wnt signaling activity during chondrogenic differentiation. Wang X, Cornelis FMF, Lories RJ, Monteagudo S. Osteoarthritis Cartilage. 2019 Nov;27(11):1702-1710. doi: 10.1016/j.joca.2019.07.007. Epub 2019 Jul 19. PubMed
Overexpression of long noncoding RNA HOXB-AS3 indicates an unfavorable prognosis and promotes tumorigenesis in epithelial ovarian cancer via Wnt/beta-catenin signaling pathway. Zhuang XH, Liu Y, Li JL. Biosci Rep. 2019 Aug 2;39(8). pii: BSR20190906. doi: 10.1042/BSR20190906. Print 2019 Aug 30. PubMed
Newcastle disease virus mediated apoptosis and migration inhibition of human oral cancer cells: A probable role of beta-catenin and matrix metalloproteinase-7. Morla S, Kumar A, Kumar S. Sci Rep. 2019 Jul 26;9(1):10882. doi: 10.1038/s41598-019-47244-y. PubMed
Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction. Costa R, Peruzzo R, Bachmann M, Monta GD, Vicario M, Santinon G, Mattarei A, Moro E, Quintana-Cabrera R, Scorrano L, Zeviani M, Vallese F, Zoratti M, Paradisi C, Argenton F, Brini M, Cali T, Dupont S, Szabo I, Leanza L. Cell Rep. 2019 Aug 20;28(8):1949-1960.e6. doi: 10.1016/j.celrep.2019.07.050. PubMed
Mutationally-activated PI3'-kinase-alpha promotes de-differentiation of lung tumors initiated by the BRAF(V600E) oncoprotein kinase. van Veen JE, Scherzer M, Boshuizen J, Chu M, Liu A, Landman A, Green S, Trejo C, McMahon M. Elife. 2019 Aug 27;8. pii: 43668. doi: 10.7554/eLife.43668. PubMed
FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy. Diaz Osterman CJ, Ozmadenci D, Kleinschmidt EG, Taylor KN, Barrie AM, Jiang S, Bean LM, Sulzmaier FJ, Jean C, Tancioni I, Anderson K, Uryu S, Cordasco EA, Li J, Chen XL, Fu G, Ojalill M, Rappu P, Heino J, Mark AM, Xu G, Fisch KM, Kolev VN, Weaver DT, Pachter JA, Gyorffy B, McHale MT, Connolly DC, Molinolo A, Stupack DG, Schlaepfer DD. Elife. 2019 Sep 3;8. pii: 47327. doi: 10.7554/eLife.47327. PubMed
Silencing of CARMA3 inhibits bladder cancer cell migration and invasion via deactivating beta-catenin signaling pathway. Man X, Liu T, Jiang Y, Zhang Z, Zhu Y, Li Z, Kong C, He J. Onco Targets Ther. 2019 Aug 9;12:6309-6322. doi: 10.2147/OTT.S191502. eCollection 2019. PubMed
Proton pump inhibitors attenuate myofibroblast formation associated with thyroid eye disease through the aryl hydrocarbon receptor. Hammond CL, Roztocil E, Phipps RP, Feldon SE, Woeller CF. PLoS One. 2019 Sep 19;14(9):e0222779. doi: 10.1371/journal.pone.0222779. eCollection 2019. PubMed
HER2 Regulates Cancer Stem Cell Activities via the Wnt Signaling Pathway in Gastric Cancer Cells. Jung DH, Bae YJ, Kim JH, Shin YK, Jeung HC. Oncology. 2019;97(5):311-318. doi: 10.1159/000502845. Epub 2019 Sep 24. PubMed
Targeting transcription factor TCF4 by gamma-Mangostin, a natural xanthone. Krishnamachary B, Subramaniam D, Dandawate P, Ponnurangam S, Srinivasan P, Ramamoorthy P, Umar S, Thomas SM, Dhar A, Septer S, Weir SJ, Attard T, Anant S. Oncotarget. 2019 Sep 24;10(54):5576-5591. doi: 10.18632/oncotarget.27159. eCollection 2019 Sep 24. PubMed
Pathogenic FAM83G palmoplantar keratoderma mutations inhibit the PAWS1:CK1alpha association and attenuate Wnt signalling. Wu KZL, Jones RA, Tachie-Menson T, Macartney TJ, Wood NT, Varghese J, Gourlay R, Soares RF, Smith JC, Sapkota GP. Wellcome Open Res. 2019 Sep 9;4:133. doi: 10.12688/wellcomeopenres.15403.1. eCollection 2019. PubMed
An integrative pharmacogenomics analysis identifies therapeutic targets in KRAS-mutant lung cancer. Wang H, Lv Q, Xu Y, Cai Z, Zheng J, Cheng X, Dai Y, Janne PA, Ambrogio C, Kohler J. EBioMedicine. 2019 Nov;49:106-117. doi: 10.1016/j.ebiom.2019.10.012. Epub 2019 Oct 23. PubMed
SOX21 Ensures Rostral Forebrain Identity by Suppression of WNT8B during Neural Regionalization of Human Embryonic Stem Cells. Fang Z, Liu X, Wen J, Tang F, Zhou Y, Jing N, Jin Y. Stem Cell Reports. 2019 Dec 10;13(6):1038-1052. doi: 10.1016/j.stemcr.2019.10.013. Epub 2019 Nov 21. PubMed
TRIM30 modulates Interleukin-22-regulated papillary thyroid Cancer cell migration and invasion by targeting Sox17 for K48-linked Polyubiquitination. Li W, Li F, Lei W, Tao Z. Cell Commun Signal. 2019 Dec 10;17(1):162. doi: 10.1186/s12964-019-0484-6. PubMed
Luminescent and fluorescent triple reporter plasmid constructs for Wnt, Hedgehog and Notch pathway. Maier J, Elmenofi S, Taschauer A, Anton M, Sami H, Ogris M. PLoS One. 2019 Dec 20;14(12):e0226570. doi: 10.1371/journal.pone.0226570. eCollection 2019. PubMed

Associated Plasmids

miR-424-5p Promotes Anoikis Resistance and Lung Metastasis by Inactivating Hippo Signaling in Thyroid Cancer. Liu X, Fu Y, Zhang G, Zhang D, Liang N, Li F, Li C, Sui C, Jiang J, Lu H, Zhao Z, Dionigi G, Sun H. Mol Ther Oncolytics. 2019 Nov 13;15:248-260. doi: 10.1016/j.omto.2019.10.008. eCollection 2019 Dec 20. PubMed
Cytokeratin 5 alters beta-catenin dynamics in breast cancer cells. McGinn O, Ward AV, Fettig LM, Riley D, Ivie J, Paul KV, Kabos P, Finlay-Schultz J, Sartorius CA. Oncogene. 2020 Mar;39(12):2478-2492. doi: 10.1038/s41388-020-1164-0. Epub 2020 Jan 27. PubMed
Cancer cell-intrinsic function of CD177 in attenuating beta-catenin signaling. Kluz PN, Kolb R, Xie Q, Borcherding N, Liu Q, Luo Y, Kim MC, Wang L, Zhang Y, Li W, Stipp C, Gibson-Corley KN, Zhao C, Qi HH, Bellizzi A, Tao AW, Sugg S, Weigel RJ, Zhou D, Shen X, Zhang W. Oncogene. 2020 Apr;39(14):2877-2889. doi: 10.1038/s41388-020-1203-x. Epub 2020 Feb 10. PubMed
ALDH1A1 maintains the cancer stem-like cells properties of esophageal squamous cell carcinoma by activating the AKT signal pathway and interacting with beta-catenin. Wang W, He S, Zhang R, Peng J, Guo D, Zhang J, Xiang B, Li L. Biomed Pharmacother. 2020 May;125:109940. doi: 10.1016/j.biopha.2020.109940. Epub 2020 Feb 7. PubMed
Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ss-catenin. Zhou T, Gao B, Fan Y, Liu Y, Feng S, Cong Q, Zhang X, Zhou Y, Yadav PS, Lin J, Wu N, Zhao L, Huang D, Zhou S, Su P, Yang Y. Elife. 2020 Mar 18;9. pii: 52779. doi: 10.7554/eLife.52779. PubMed
Truncating mutations in SHANK3 associated with global developmental delay interfere with nuclear beta-catenin signaling. Hassani Nia F, Woike D, Kloth K, Kortum F, Kreienkamp HJ. J Neurochem. 2020 Mar 23. doi: 10.1111/jnc.15014. PubMed
The Inhibition of Wnt Restrain KRAS(G12V)-Driven Metastasis in Non-Small-Cell Lung Cancer. Hung PS, Huang MH, Kuo YY, Yang JC. Cancers (Basel). 2020 Mar 31;12(4). pii: cancers12040837. doi: 10.3390/cancers12040837. PubMed
Inhibition of GSK3 Represses the Expression of Retinoic Acid Synthetic Enzyme ALDH1A2 via Wnt/beta-Catenin Signaling in WiT49 Cells. Li Y, Gong H, Ding J, Zhao F, Du J, Wan J, Zhang J, Liu S, Li J, Wang L, Zhou B. Front Cell Dev Biol. 2020 Mar 17;8:94. doi: 10.3389/fcell.2020.00094. eCollection 2020. PubMed
Gain-of-Function Genetic Alterations of G9a Drive Oncogenesis. Kato S, Weng QY, Insco ML, Chen KY, Muralidhar S, Pozniak J, Diaz JMS, Drier Y, Nguyen N, Lo JA, van Rooijen E, Kemeny LV, Zhan Y, Feng Y, Silkworth W, Powell CT, Liau BB, Xiong Y, Jin J, Newton-Bishop J, Zon LI, Bernstein BE, Fisher DE. Cancer Discov. 2020 Jul;10(7):980-997. doi: 10.1158/2159-8290.CD-19-0532. Epub 2020 Apr 8. PubMed
The heparan sulfate proteoglycan syndecan-1 regulates colon cancer stem cell function via a focal adhesion kinase-Wnt signaling axis. Kumar Katakam S, Tria V, Sim WC, Yip GW, Molgora S, Karnavas T, Elghonaimy EA, Pelucchi P, Piscitelli E, Ibrahim SA, Zucchi I, Reinbold R, Greve B, Gotte M. FEBS J. 2021 Jan;288(2):486-506. doi: 10.1111/febs.15356. Epub 2020 May 25. PubMed
Inhibition of Wnt/beta-catenin pathway reverses multi-drug resistance and EMT in Oct4(+)/Nanog(+) NSCLC cells. Liu L, Zhu H, Liao Y, Wu W, Liu L, Liu L, Wu Y, Sun F, Lin HW. Biomed Pharmacother. 2020 Jul;127:110225. doi: 10.1016/j.biopha.2020.110225. Epub 2020 May 16. PubMed
LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/beta-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes. Zhou C, Yi C, Yi Y, Qin W, Yan Y, Dong X, Zhang X, Huang Y, Zhang R, Wei J, Ali DW, Michalak M, Chen XZ, Tang J. Mol Cancer. 2020 Jul 29;19(1):118. doi: 10.1186/s12943-020-01237-y. PubMed
SOX6 represses tumor growth of clear cell renal cell carcinoma by HMG domain-dependent regulation of Wnt/beta-catenin signaling. Chen L, Xie Y, Ma X, Zhang Y, Li X, Zhang F, Gao Y, Fan Y, Gu L, Wang L, Zhang X, Fu B. Mol Carcinog. 2020 Oct;59(10):1159-1173. doi: 10.1002/mc.23246. Epub 2020 Aug 14. PubMed
TBX3 acts as tissue-specific component of the Wnt/beta-catenin transcriptional complex. Zimmerli D, Borrelli C, Jauregi-Miguel A, Soderholm S, Brutsch S, Doumpas N, Reichmuth J, Murphy-Seiler F, Aguet M, Basler K, Moor AE, Cantu C. Elife. 2020 Aug 18;9. pii: 58123. doi: 10.7554/eLife.58123. PubMed
A uniform expression library for the exploration of FOX transcription factor biology. Moparthi L, Koch S. Differentiation. 2020 Sep - Oct;115:30-36. doi: 10.1016/j.diff.2020.08.002. Epub 2020 Aug 20. PubMed
IMU1003, an atrarate derivative, inhibits Wnt/beta-catenin signaling. Yonezawa H, Sugawara A, Sakyo T, Uehara Y, Kawano T, Nishiya N. Biochem Biophys Res Commun. 2020 Nov 12;532(3):440-445. doi: 10.1016/j.bbrc.2020.08.031. Epub 2020 Sep 3. PubMed
Estrogen receptor-beta signaling induces cisplatin resistance in bladder cancer. Goto T, Kashiwagi E, Jiang G, Nagata Y, Teramoto Y, Baras AS, Yamashita S, Ito A, Arai Y, Miyamoto H. Am J Cancer Res. 2020 Aug 1;10(8):2523-2534. eCollection 2020. PubMed
Viruses harness YxxO motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target. Yuan S, Chu H, Huang J, Zhao X, Ye ZW, Lai PM, Wen L, Cai JP, Mo Y, Cao J, Liang R, Poon VK, Sze KH, Zhou J, To KK, Chen Z, Chen H, Jin DY, Chan JF, Yuen KY. Sci Adv. 2020 Aug 28;6(35):eaba7910. doi: 10.1126/sciadv.aba7910. eCollection 2020 Aug. PubMed
beta-Catenin inhibition shapes tumor immunity and synergizes with immunotherapy in colorectal cancer. Wang C, Yan J, Yin P, Gui L, Ji L, Ma B, Gao WQ. Oncoimmunology. 2020 Aug 31;9(1):1809947. doi: 10.1080/2162402X.2020.1809947. PubMed
Wnt signaling mediates oncogenic synergy between Akt and Dlx5 in T-cell lymphomagenesis by enhancing cholesterol synthesis. Tan Y, Sementino E, Liu Z, Cai KQ, Testa JR. Sci Rep. 2020 Sep 28;10(1):15837. doi: 10.1038/s41598-020-72822-w. PubMed
Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the family. Peruzzo R, Mattarei A, Azzolini M, Becker-Flegler KA, Romio M, Rigoni G, Carrer A, Biasutto L, Parrasia S, Kadow S, Manago A, Urbani A, Rossa A, Semenzato G, Soriano ME, Trentin L, Ahmad S, Edwards M, Gulbins E, Paradisi C, Zoratti M, Leanza L, Szabo I. Redox Biol. 2020 Oct;37:101705. doi: 10.1016/j.redox.2020.101705. Epub 2020 Sep 6. PubMed
Activated Beta-Catenin Signaling Ameliorates Radiation-Induced Skin Injury by Suppressing Marvel D3 Expression. Cao J, Zhong L, Feng Y, Qian K, Xiao Y, Wang G, Tu W, Yue L, Zhang Q, Yang H, Jiao Y, Zhu W, Cao J. Radiat Res. 2021 Feb 1;195(2):173-190. doi: 10.1667/RADE-20-00050.1. PubMed
Volumetric Compression Induces Intracellular Crowding to Control Intestinal Organoid Growth via Wnt/beta-Catenin Signaling. Li Y, Chen M, Hu J, Sheng R, Lin Q, He X, Guo M. Cell Stem Cell. 2021 Jan 7;28(1):63-78.e7. doi: 10.1016/j.stem.2020.09.012. Epub 2020 Oct 13. PubMed
Dehydroxyhispolon Methyl Ether, A Hispolon Derivative, Inhibits WNT/beta-Catenin Signaling to Elicit Human Colorectal Carcinoma Cell Apoptosis. Fan HC, Hsieh YC, Li LH, Chang CC, Janouskova K, Ramani MV, Subbaraju GV, Cheng KT, Chang CC. Int J Mol Sci. 2020 Nov 22;21(22). pii: ijms21228839. doi: 10.3390/ijms21228839. PubMed
Embryonic Stem Cell Differentiation Is Regulated by SET through Interactions with p53 and beta-Catenin. Harikumar A, Lim PSL, Nissim-Rafinia M, Park JE, Sze SK, Meshorer E. Stem Cell Reports. 2020 Dec 8;15(6):1260-1274. doi: 10.1016/j.stemcr.2020.11.004. PubMed
Long Noncoding RNA DANCR Activates Wnt/beta-Catenin Signaling through MiR-216a Inhibition in Non-Small Cell Lung Cancer. Yu JE, Ju JA, Musacchio N, Mathias TJ, Vitolo MI. Biomolecules. 2020 Dec 8;10(12). pii: biom10121646. doi: 10.3390/biom10121646. PubMed
Selective activation of FZD7 promotes mesendodermal differentiation of human pluripotent stem cells. Gumber D, Do M, Suresh Kumar N, Sonavane PR, Wu CCN, Cruz LS, Grainger S, Carson D, Gaasterland T, Willert K. Elife. 2020 Dec 17;9. pii: 63060. doi: 10.7554/eLife.63060. PubMed
CMTM6 drives cisplatin resistance by regulating Wnt signaling through the ENO-1/AKT/GSK3beta axis. Mohapatra P, Shriwas O, Mohanty S, Ghosh A, Smita S, Kaushik SR, Arya R, Rath R, Das Majumdar SK, Muduly DK, Raghav SK, Nanda RK, Dash R. JCI Insight. 2021 Feb 22;6(4). pii: 143643. doi: 10.1172/jci.insight.143643. PubMed
The effect of strontium ranelate on titanium particle-induced periprosthetic osteolysis regulated by WNT/beta-catenin signaling in vivo and in vitro. Wang B, Guo H, Geng T, Sun K, Zhang L, Lu Z, Jin Q. Biosci Rep. 2021 Jan 29;41(1). pii: 227588. doi: 10.1042/BSR20203003. PubMed
FOLFOX Therapy Induces Feedback Upregulation of CD44v6 through YB-1 to Maintain Stemness in Colon Initiating Cells. Ghatak S, Hascall VC, Markwald RR, Misra S. Int J Mol Sci. 2021 Jan 13;22(2). pii: ijms22020753. doi: 10.3390/ijms22020753. PubMed
A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells. Murakami K, Terakado Y, Saito K, Jomen Y, Takeda H, Oshima M, Barker N. Proc Natl Acad Sci U S A. 2021 Jan 26;118(4). pii: 2016806118. doi: 10.1073/pnas.2016806118. PubMed
Colorectal Cancer-Associated Smad4 R361 Hotspot Mutations Boost Wnt/beta-Catenin Signaling through Enhanced Smad4-LEF1 Binding. Lanauze CB, Sehgal P, Hayer K, Torres-Diz M, Pippin JA, Grant SFA, Thomas-Tikhonenko A. Mol Cancer Res. 2021 May;19(5):823-833. doi: 10.1158/1541-7786.MCR-20-0721. Epub 2021 Feb 19. PubMed
Modulation of lanosterol synthase drives 24,25-epoxysterol synthesis and oligodendrocyte formation. Hubler Z, Friedrich RM, Sax JL, Allimuthu D, Gao F, Rivera-Leon AM, Pleshinger MJ, Bederman I, Adams DJ. Cell Chem Biol. 2021 Jun 17;28(6):866-875.e5. doi: 10.1016/j.chembiol.2021.01.025. Epub 2021 Feb 25. PubMed
CST1 Promoted Gastric Cancer Migration and Invasion Through Activating Wnt Pathway. Chen S, Liu Y, Zhang K, Chen L. Cancer Manag Res. 2021 Feb 24;13:1901-1907. doi: 10.2147/CMAR.S277770. eCollection 2021. PubMed
N-cadherin upregulation mediates adaptive radioresistance in glioblastoma. Osuka S, Zhu D, Zhang Z, Li C, Stackhouse CT, Sampetrean O, Olson JJ, Gillespie GY, Saya H, Willey CD, Van Meir EG. J Clin Invest. 2021 Mar 15;131(6). pii: 136098. doi: 10.1172/JCI136098. PubMed
Pyrvinium Treatment Confers Hepatic Metabolic Benefits via beta-Catenin Downregulation and AMPK Activation. Zhou S, Obianom ON, Huang J, Guo D, Yang H, Li Q, Shu Y. Pharmaceutics. 2021 Mar 4;13(3). pii: pharmaceutics13030330. doi: 10.3390/pharmaceutics13030330. PubMed
DZIP1 regulates mammalian cardiac valve development through a Cby1-beta-catenin mechanism. Guo L, Beck T, Fulmer D, Ramos-Ortiz S, Glover J, Wang C, Moore K, Gensemer C, Morningstar J, Moore R, Schott JJ, Le Tourneau T, Koren N, Norris RA. Dev Dyn. 2021 Apr 2. doi: 10.1002/dvdy.342. PubMed
Reduced RECK levels accelerate skeletal muscle differentiation, improve muscle regeneration, and decrease fibrosis. Gutierrez J, Gonzalez D, Escalona-Rivano R, Takahashi C, Brandan E. FASEB J. 2021 May;35(5):e21503. doi: 10.1096/fj.202001646RR. PubMed
Zbed3 Is Indispensable for Wnt Signaling Regulation of Cortical Layers Formation in Developing Brain. Ruan X, Liu G, Zhou J, Chen P, Sun C, Liu W, Wu C, Hou L, Yin B, Qiang B, Shu P, Peng X. Cereb Cortex. 2021 Jul 29;31(9):4078-4091. doi: 10.1093/cercor/bhab070. PubMed
Homeobox-A13 acts as a functional prognostic and diagnostic biomarker via regulating P53 and Wnt signaling pathways in lung cancer. Wang Y, He B, Dong Y, He GJ, Qi XW, Li Y, Yang YF, Rao Y, Cen ZS, Han F, Ding J, Li JJ. Cancer Biomark. 2021;31(3):239-254. doi: 10.3233/CBM-200540. PubMed
Multilevel Regulation of beta-Catenin Activity by SETD2 Suppresses the Transition from Polycystic Kidney Disease to Clear Cell Renal Cell Carcinoma. Rao H, Li X, Liu M, Liu J, Feng W, Tang H, Xu J, Gao WQ, Li L. Cancer Res. 2021 Jul 1;81(13):3554-3567. doi: 10.1158/0008-5472.CAN-20-3960. Epub 2021 Apr 28. PubMed
Downregulation of ARID1B, a tumor suppressor in the WNT subgroup medulloblastoma, activates multiple oncogenic signaling pathways. Deogharkar A, Singh SV, Bharambe HS, Paul R, Moiyadi A, Goel A, Shetty P, Sridhar E, Gupta T, Jalali R, Goel N, Gadewal N, Muthukumar S, Shirsat NV. Hum Mol Genet. 2021 Aug 28;30(18):1721-1733. doi: 10.1093/hmg/ddab134. PubMed
Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of beta-catenin signaling. Kim YM, Krantz S, Jambusaria A, Toth PT, Moon HG, Gunarathna I, Park GY, Rehman J. Nat Commun. 2021 May 12;12(1):2736. doi: 10.1038/s41467-021-23047-6. PubMed
Cell surface GRP78 and Dermcidin cooperate to regulate breast cancer cell migration through Wnt signaling. Lager TW, Conner C, Keating CR, Warshaw JN, Panopoulos AD. Oncogene. 2021 Jun;40(23):4050-4059. doi: 10.1038/s41388-021-01821-6. Epub 2021 May 12. PubMed
The human WNT5A isoforms display similar patterns of expression but distinct and overlapping activities in normal human osteoblasts. Bhandari D, Elshaarrawi A, Katula KS. J Cell Biochem. 2021 May 13. doi: 10.1002/jcb.29950. PubMed
miR-433-3p suppresses bone formation and mRNAs critical for osteoblast function in mice. Garcia J, Smith SS, Karki S, Drissi H, Hrdlicka HH, Youngstrom DW, Delany AM. J Bone Miner Res. 2021 Sep;36(9):1808-1822. doi: 10.1002/jbmr.4339. Epub 2021 Jun 4. PubMed
Isoorientin inhibits epithelial-to-mesenchymal properties and cancer stem-cell-like features in oral squamous cell carcinoma by blocking Wnt/beta-catenin/STAT3 axis. Liu SC, Huang CS, Huang CM, Hsieh MS, Huang MS, Fong IH, Yeh CT, Lin CC. Toxicol Appl Pharmacol. 2021 Aug 1;424:115581. doi: 10.1016/j.taap.2021.115581. Epub 2021 May 18. PubMed
Optogenetic Control of the Canonical Wnt Signaling Pathway During Xenopus laevis Embryonic Development. Krishnamurthy VV, Hwang H, Fu J, Yang J, Zhang K. J Mol Biol. 2021 Sep 3;433(18):167050. doi: 10.1016/j.jmb.2021.167050. Epub 2021 May 19. PubMed
Inhibiting Wnt/beta-catenin in CTNNB1-mutated endometrial cancer. Moroney MR, Woodruff E, Qamar L, Bradford AP, Wolsky R, Bitler BG, Corr BR. Mol Carcinog. 2021 Aug;60(8):511-523. doi: 10.1002/mc.23308. Epub 2021 May 26. PubMed
miR-637 Prevents Glioblastoma Progression by Interrupting ZEB2/WNT/beta-catenin Cascades. Wang W, Zhao Z, Han S, Wu D. Cell Mol Neurobiol. 2021 May 28. pii: 10.1007/s10571-021-01107-1. doi: 10.1007/s10571-021-01107-1. PubMed
ICG-001, an Inhibitor of the beta-Catenin and cAMP Response Element-Binding Protein Dependent Gene Transcription, Decreases Proliferation but Enhances Migration of Osteosarcoma Cells. Danieau G, Morice S, Renault S, Brion R, Biteau K, Amiaud J, Cade M, Heymann D, Lezot F, Verrecchia F, Redini F, Brounais-Le Royer B. Pharmaceuticals (Basel). 2021 May 1;14(5). pii: ph14050421. doi: 10.3390/ph14050421. PubMed
A Wnt-Independent LGR4-EGFR Signaling Axis in Cancer Metastasis. Yue F, Jiang W, Ku AT, Young AIJ, Zhang W, Souto EP, Gao Y, Yu Z, Wang Y, Creighton CJ, Nagi C, Wang T, Hilsenbeck SG, Feng XH, Huang S, Coarfa C, Zhang XH, Liu Q, Lin X, Li Y. Cancer Res. 2021 Sep 1;81(17):4441-4454. doi: 10.1158/0008-5472.CAN-21-1112. Epub 2021 Jun 7. PubMed
miR-802 regulates Paneth cell function and enterocyte differentiation in the mouse small intestine. Goga A, Yagabasan B, Herrmanns K, Godbersen S, Silva PN, Denzler R, Zund M, Furter M, Schwank G, Sunagawa S, Hardt WD, Stoffel M. Nat Commun. 2021 Jun 7;12(1):3339. doi: 10.1038/s41467-021-23298-3. PubMed
Targeted Protein Degradation through Fast Optogenetic Activation and Its Application to the Control of Cell Signaling. Ryan A, Liu J, Deiters A. J Am Chem Soc. 2021 Jun 23;143(24):9222-9229. doi: 10.1021/jacs.1c04324. Epub 2021 Jun 13. PubMed
Mist1 Inhibits Epithelial-Mesenchymal Transition in Gastric Adenocarcinoma via Downregulating the Wnt/beta-catenin Pathway. Xie X, Zhou Z, Song Y, Zhang X, Dang C, Zhang H. J Cancer. 2021 Jun 1;12(15):4574-4584. doi: 10.7150/jca.59138. eCollection 2021. PubMed
Quantitative Profiling of WNT-3A Binding to All Human Frizzled Paralogues in HEK293 Cells by NanoBiT/BRET Assessments. Kozielewicz P, Shekhani R, Moser S, Bowin CF, Wesslowski J, Davidson G, Schulte G. ACS Pharmacol Transl Sci. 2021 May 11;4(3):1235-1245. doi: 10.1021/acsptsci.1c00084. eCollection 2021 Jun 11. PubMed
Residue 6.43 defines receptor function in class F GPCRs. Turku A, Schihada H, Kozielewicz P, Bowin CF, Schulte G. Nat Commun. 2021 Jun 24;12(1):3919. doi: 10.1038/s41467-021-24004-z. PubMed
Low-Density Lipoprotein Receptor-Related Protein 6 Cell Surface Availability Regulates Fuel Metabolism in Astrocytes. Chow HM, Sun JK, Hart RP, Cheng KK, Hung CHL, Lau TM, Kwan KM. Adv Sci (Weinh). 2021 Aug;8(16):e2004993. doi: 10.1002/advs.202004993. Epub 2021 Jun 27. PubMed
beta-Catenin Restricts Zika Virus Internalization by Downregulating Axl. Jimenez OA, Narasipura SD, Barbian HJ, Albalawi YA, Seaton MS, Robinson KF, Al-Harthi L. J Virol. 2021 Aug 10;95(17):e0070521. doi: 10.1128/JVI.00705-21. Epub 2021 Aug 10. PubMed
EVI1 activates tumor-promoting transcriptional enhancers in pancreatic cancer. Kim HR, Yim J, Yoo HB, Lee SE, Oh S, Jung S, Hwang CI, Shin DM, Kim T, Yoo KH, Kim YS, Lee HW, Roe JS. NAR Cancer. 2021 Jun 17;3(2):zcab023. doi: 10.1093/narcan/zcab023. eCollection 2021 Jun. PubMed
LncRNA H19 Promoted the Epithelial to Mesenchymal Transition and Metastasis in Gastric Cancer via Activating Wnt/beta-Catenin Signaling. Liu J, Wang G, Zhao J, Liu X, Zhang K, Gong G, Pan H, Jiang Z. Dig Dis. 2021 Jul 27. pii: 000518627. doi: 10.1159/000518627. PubMed
Intrinsic activation of beta-catenin signaling by CRISPR/Cas9-mediated exon skipping contributes to immune evasion in hepatocellular carcinoma. Akasu M, Shimada S, Kabashima A, Akiyama Y, Shimokawa M, Akahoshi K, Kudo A, Yamaoka S, Tanabe M, Tanaka S. Sci Rep. 2021 Aug 24;11(1):16732. doi: 10.1038/s41598-021-96167-0. PubMed
ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium. Ma X, Takahashi Y, Wu W, Liang W, Chen J, Chakraborty D, Li Y, Du Y, Benyajati S, Ma JX. J Biol Chem. 2021 Oct;297(4):101185. doi: 10.1016/j.jbc.2021.101185. Epub 2021 Sep 10. PubMed
Assessing the Wnt-reactivity of cytonemes of mouse embryonic stem cells using a bioengineering approach. Junyent S, Reeves J, Habib SJ. STAR Protoc. 2021 Sep 15;2(3):100813. doi: 10.1016/j.xpro.2021.100813. eCollection 2021 Sep 17. PubMed
Mechanosensitive miR-100 coordinates TGFbeta and Wnt signaling in osteocytes during fluid shear stress. Dole NS, Yoon J, Monteiro DA, Yang J, Mazur CM, Kaya S, Belair CD, Alliston T. FASEB J. 2021 Oct;35(10):e21883. doi: 10.1096/fj.202100930. PubMed
The Candidate IBD Risk Gene CCNY Is Dispensable for Intestinal Epithelial Homeostasis. Molinas A, Heil S, Koch S. Cells. 2021 Sep 6;10(9). pii: cells10092330. doi: 10.3390/cells10092330. PubMed
Niclosamide and Pyrvinium Are Both Potential Therapeutics for Osteosarcoma, Inhibiting Wnt-Axin2-Snail Cascade. Yi Y, Woo YM, Hwang KH, Kim HS, Lee SH. Cancers (Basel). 2021 Sep 15;13(18). pii: cancers13184630. doi: 10.3390/cancers13184630. PubMed
Antioxidant and Antiproliferative Activity of Finasteride against Glioblastoma Cells. Kim HJ, Kim TJ, Kim YG, Seong C, Cho JH, Kim W, Lee KH, Kim DY. Pharmaceutics. 2021 Sep 6;13(9). pii: pharmaceutics13091410. doi: 10.3390/pharmaceutics13091410. PubMed
Differentiation of mouse fetal lung alveolar progenitors in serum-free organotypic cultures. Gkatzis K, Panza P, Peruzzo S, Stainier DY. Elife. 2021 Sep 29;10. pii: 65811. doi: 10.7554/eLife.65811. PubMed
MYC Hyperactivates Wnt Signaling in APC/CTNNB1-Mutated Colorectal Cancer Cells through miR-92a-Dependent Repression of DKK3. Sehgal P, Lanauze C, Wang X, Hayer KE, Torres-Diz M, Leu NA, Sela Y, Stanger BZ, Lengner CJ, Thomas-Tikhonenko A. Mol Cancer Res. 2021 Dec;19(12):2003-2014. doi: 10.1158/1541-7786.MCR-21-0666. Epub 2021 Sep 30. PubMed
Transmembrane protein TMEM184B is necessary for interleukin-31-induced itch. Larsen EG, Cho TS, McBride ML, Feng J, Manivannan B, Madura C, Klein NE, Wright EB, Wickstead ES, Garcia-Verdugo HD, Jarvis C, Khanna R, Hu H, Largent-Milnes TM, Bhattacharya MRC. Pain. 2022 May 1;163(5):e642-e653. doi: 10.1097/j.pain.0000000000002452. PubMed
The FHP01 DDX3X Helicase Inhibitor Exerts Potent Anti-Tumor Activity In Vivo in Breast Cancer Pre-Clinical Models. Gherardini L, Inzalaco G, Imperatore F, D'Aurizio R, Franci L, Miragliotta V, Boccuto A, Calandro P, Andreini M, Tarditi A, Chiariello M. Cancers (Basel). 2021 Sep 27;13(19). pii: cancers13194830. doi: 10.3390/cancers13194830. PubMed
Inhibition of Wnt/beta-Catenin Signaling Sensitizes Esophageal Cancer Cells to Chemoradiotherapy. Spitzner M, Emons G, Schutz KB, Wolff HA, Rieken S, Ghadimi BM, Schneider G, Grade M. Int J Mol Sci. 2021 Sep 24;22(19). pii: ijms221910301. doi: 10.3390/ijms221910301. PubMed
MsrB1 Promotes Proliferation and Invasion of Colorectal Cancer Cells via GSK-3beta/beta-catenin Signaling Axis. Chen XY, Yang SY, Ruan XJ, Ding HY, Wang NX, Liu F, Li JC, Li Y. Cell Transplant. 2021 Jan-Dec;30:9636897211053203. doi: 10.1177/09636897211053203. PubMed
Disruption of beta-Catenin-Dependent Wnt Signaling in Colon Cancer Cells Remodels the Microenvironment to Promote Tumor Invasion. Chen GT, Tifrea DF, Murad R, Habowski AN, Lyou Y, Duong MR, Hosohama L, Mortazavi A, Edwards RA, Waterman ML. Mol Cancer Res. 2022 Mar 1;20(3):468-484. doi: 10.1158/1541-7786.MCR-21-0349. PubMed
Dickkopf-1 Inhibition Reactivates Wnt/beta-Catenin Signaling in Rhabdomyosarcoma, Induces Myogenic Markers In Vitro and Impairs Tumor Cell Survival In Vivo. Giralt I, Gallo-Oller G, Navarro N, Zarzosa P, Pons G, Magdaleno A, Segura MF, Sabado C, Hladun R, Arango D, Sanchez de Toledo J, Moreno L, Gallego S, Roma J. Int J Mol Sci. 2021 Nov 29;22(23). pii: ijms222312921. doi: 10.3390/ijms222312921. PubMed
Functional analysis of the 1p34.3 risk locus implicates GNL2 in high-grade serous ovarian cancer. Nakamura K, Reid BM, Chen A, Chen Z, Goode EL, Permuth JB, Teer JK, Tyrer J, Yu X, Kanetsky PA, Pharoah PD, Gayther SA, Sellers TA, Lawrenson K, Karreth FA. Am J Hum Genet. 2022 Jan 6;109(1):116-135. doi: 10.1016/j.ajhg.2021.11.020. Epub 2021 Dec 28. PubMed
A novel C-terminal heat shock protein 90 inhibitor that overcomes STAT3-Wnt-beta-catenin signaling-mediated drug resistance and adverse effects. Lee HJ, Min HY, Yong YS, Ann J, Nguyen CT, La MT, Hyun SY, Le HT, Kim H, Kwon H, Nam G, Park HJ, Lee J, Lee HY. Theranostics. 2022 Jan 1;12(1):105-125. doi: 10.7150/thno.63788. eCollection 2022. PubMed
Reconstitution of purified membrane protein dimers in lipid nanodiscs with defined stoichiometry and orientation using a split GFP tether. Bruguera ES, Mahoney JP, Weis WI. J Biol Chem. 2022 Jan 21:101628. doi: 10.1016/j.jbc.2022.101628. PubMed

Associated Plasmids

Evidence for a Dual-Pathway, 2-Hit Genetic Model for Focal Cortical Dysplasia and Epilepsy. Bennett MF, Hildebrand MS, Kayumi S, Corbett MA, Gupta S, Ye Z, Krivanek M, Burgess R, Henry OJ, Damiano JA, Boys A, Gecz J, Bahlo M, Scheffer IE, Berkovic SF. Neurol Genet. 2022 Jan 25;8(1):e652. doi: 10.1212/NXG.0000000000000652. eCollection 2022 Feb. PubMed
Regulation of Myogenesis by a Na/K-ATPase alpha1 Caveolin-Binding Motif. Huang M, Wang X, Banerjee M, Mukherji ST, Kutz LC, Zhao A, Sepanski M, Fan CM, Zhu GZ, Tian J, Wang DZ, Zhu H, Xie ZJ, Pierre SV, Cai L. Stem Cells. 2022 Mar 16;40(2):133-148. doi: 10.1093/stmcls/sxab012. PubMed
Design, synthesis and evaluation of 4,7-disubstituted 8-methoxyquinazoline derivatives as potential cytotoxic agents targeting beta-catenin/TCF4 signaling pathway. Neogi K, Murumkar PR, Sharma P, Yadav P, Tewari M, Karunagaran D, Nayak PK, Yadav MR. Transl Oncol. 2022 May;19:101395. doi: 10.1016/j.tranon.2022.101395. Epub 2022 Mar 21. PubMed
Canonical Wnt signaling induces focal adhesion and Integrin beta-1 endocytosis. Tejeda-Munoz N, Morselli M, Moriyama Y, Sheladiya P, Pellegrini M, De Robertis EM. iScience. 2022 Mar 19;25(4):104123. doi: 10.1016/j.isci.2022.104123. eCollection 2022 Apr 15. PubMed
Human pancreatic microenvironment promotes beta-cell differentiation via non-canonical WNT5A/JNK and BMP signaling. Chmielowiec J, Szlachcic WJ, Yang D, Scavuzzo MA, Wamble K, Sarrion-Perdigones A, Sabek OM, Venken KJT, Borowiak M. Nat Commun. 2022 Apr 12;13(1):1952. doi: 10.1038/s41467-022-29646-1. PubMed
RNF43 R117fs mutant positively regulates Wnt/beta-catenin signaling by failing to internalize FZD expressed on the cell surface. Cho AR, Sul HJ, Kim YJ, Kim B, Zang DY. Sci Rep. 2022 Apr 29;12(1):7013. doi: 10.1038/s41598-022-10868-8. PubMed
Transcription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron content. Papes F, Camargo AP, de Souza JS, Carvalho VMA, Szeto RA, LaMontagne E, Teixeira JR, Avansini SH, Sanchez-Sanchez SM, Nakahara TS, Santo CN, Wu W, Yao H, Araujo BMP, Velho PENF, Haddad GG, Muotri AR. Nat Commun. 2022 May 2;13(1):2387. doi: 10.1038/s41467-022-29942-w. PubMed
Ivermectin represses Wnt/beta-catenin signaling by binding to TELO2, a regulator of phosphatidylinositol 3-kinase-related kinases. Yonezawa H, Ikeda A, Takahashi R, Endo H, Sugawara Y, Goto M, Kanno M, Ogawa S, Nakamura K, Ujiie H, Iwatsuki M, Hirose T, Sunazuka T, Uehara Y, Nishiya N. iScience. 2022 Mar 7;25(3):103912. doi: 10.1016/j.isci.2022.103912. eCollection 2022 Mar 18. PubMed
5-hydroxytryptamine produced by enteric serotonergic neurons initiates colorectal cancer stem cell self-renewal and tumorigenesis. Zhu P, Lu T, Chen Z, Liu B, Fan D, Li C, Wu J, He L, Zhu X, Du Y, Tian Y, Fan Z. Neuron. 2022 Jul 20;110(14):2268-2282.e4. doi: 10.1016/j.neuron.2022.04.024. Epub 2022 May 12. PubMed
RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition. Fang L, Ford-Roshon D, Russo M, O'Brien C, Xiong X, Gurjao C, Grandclaudon M, Raghavan S, Corsello SM, Carr SA, Udeshi ND, Berstler J, Sicinska E, Ng K, Giannakis M. Nat Commun. 2022 Jun 8;13(1):3181. doi: 10.1038/s41467-022-30794-7. PubMed
The risk variant rs11836367 contributes to breast cancer onset and metastasis by attenuating Wnt signaling via regulating NTN4 expression. Yang H, Ting X, Geng YH, Xie Y, Nierenberg JL, Huo YF, Zhou YT, Huang Y, Yu YQ, Yu XY, Li XF, Ziv E, Zhang H, Fang WG, Shen Y, Tian XX. Sci Adv. 2022 Jun 10;8(23):eabn3509. doi: 10.1126/sciadv.abn3509. Epub 2022 Jun 10. PubMed

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