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pEGFP-Q74 Citations (25)

Plasmid Article: A molecular investigation of true dominance in Huntington's disease.
Narain Y, Wyttenbach A, Rankin J, Furlong RA, Rubinsztein DC J Med Genet. 1999 Oct;36(10):739-46.
PubMed Journal

Articles Citing pEGFP-Q74

Articles
Sigma-1 receptor is involved in degradation of intranuclear inclusions in a cellular model of Huntington's disease. Miki Y, Tanji K, Mori F, Wakabayashi K. Neurobiol Dis. 2015 Feb;74:25-31. doi: 10.1016/j.nbd.2014.11.005. Epub 2014 Nov 14. PubMed
HDAC6 inhibition induces mitochondrial fusion, autophagic flux and reduces diffuse mutant huntingtin in striatal neurons. Guedes-Dias P, de Proenca J, Soares TR, Leitao-Rocha A, Pinho BR, Duchen MR, Oliveira JM. Biochim Biophys Acta. 2015 Nov;1852(11):2484-93. doi: 10.1016/j.bbadis.2015.08.012. Epub 2015 Aug 21. PubMed
The Social Amoeba Dictyostelium discoideum Is Highly Resistant to Polyglutamine Aggregation. Santarriaga S, Petersen A, Ndukwe K, Brandt A, Gerges N, Bruns Scaglione J, Scaglione KM. J Biol Chem. 2015 Oct 16;290(42):25571-8. doi: 10.1074/jbc.M115.676247. Epub 2015 Sep 1. PubMed
Blocking the association of HDAC4 with MAP1S accelerates autophagy clearance of mutant Huntingtin. Yue F, Li W, Zou J, Chen Q, Xu G, Huang H, Xu Z, Zhang S, Gallinari P, Wang F, McKeehan WL, Liu L. Aging (Albany NY). 2015 Oct;7(10):839-53. PubMed
The role of NUB1 in alpha-synuclein degradation in Lewy body disease model mice. Tanji K, Miki Y, Maruyama A, Mori F, Mimura J, Itoh K, Kamitani T, Wakabayashi K. Biochem Biophys Res Commun. 2016 Jan 18. pii: S0006-291X(16)30093-6. doi: 10.1016/j.bbrc.2016.01.093. PubMed
C/EBPbeta regulates sensitivity to bortezomib in prostate cancer cells by inducing REDD1 and autophagosome-lysosome fusion. Barakat DJ, Mendonca J, Barberi T, Zhang J, Kachhap SK, Paz-Priel I, Friedman AD. Cancer Lett. 2016 May 28;375(1):152-61. doi: 10.1016/j.canlet.2016.03.005. Epub 2016 Mar 8. PubMed
Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function. Sakamaki JI, Wilkinson S, Hahn M, Tasdemir N, O'Prey J, Clark W, Hedley A, Nixon C, Long JS, New M, Van Acker T, Tooze SA, Lowe SW, Dikic I, Ryan KM. Mol Cell. 2017 May 18;66(4):517-532.e9. doi: 10.1016/j.molcel.2017.04.027. PubMed
The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress alpha-synuclein aggregation. Aprile FA, Kallstig E, Limorenko G, Vendruscolo M, Ron D, Hansen C. Sci Rep. 2017 Aug 22;7(1):9039. doi: 10.1038/s41598-017-08324-z. PubMed
A Method for the Acute and Rapid Degradation of Endogenous Proteins. Clift D, McEwan WA, Labzin LI, Konieczny V, Mogessie B, James LC, Schuh M. Cell. 2017 Nov 13. pii: S0092-8674(17)31255-2. doi: 10.1016/j.cell.2017.10.033. PubMed

Associated Plasmids

Inhibition of PIP4Kgamma ameliorates the pathological effects of mutant huntingtin protein. Al-Ramahi I, Panapakkam Giridharan SS, Chen YC, Patnaik S, Safren N, Hasegawa J, de Haro M, Wagner Gee AK, Titus SA, Jeong H, Clarke J, Krainc D, Zheng W, Irvine RF, Barmada S, Ferrer M, Southall N, Weisman LS, Botas J, Marugan JJ. Elife. 2017 Dec 26;6. pii: 29123. doi: 10.7554/eLife.29123. PubMed
YOD1 attenuates neurogenic proteotoxicity through its deubiquitinating activity. Tanji K, Mori F, Miki Y, Utsumi J, Sasaki H, Kakita A, Takahashi H, Wakabayashi K. Neurobiol Dis. 2018 Apr;112:14-23. doi: 10.1016/j.nbd.2018.01.006. Epub 2018 Jan 10. PubMed
Striatal neurons directly converted from Huntington's disease patient fibroblasts recapitulate age-associated disease phenotypes. Victor MB, Richner M, Olsen HE, Lee SW, Monteys AM, Ma C, Huh CJ, Zhang B, Davidson BL, Yang XW, Yoo AS. Nat Neurosci. 2018 Mar;21(3):341-352. doi: 10.1038/s41593-018-0075-7. Epub 2018 Feb 5. PubMed
Correction of Huntington's Disease Phenotype by Genistein-Induced Autophagy in the Cellular Model. Pierzynowska K, Gaffke L, Hac A, Mantej J, Niedzialek N, Brokowska J, Wegrzyn G. Neuromolecular Med. 2018 Mar;20(1):112-123. doi: 10.1007/s12017-018-8482-1. Epub 2018 Feb 12. PubMed
A Split Transcriptional Repressor That Links Protein Solubility to an Orthogonal Genetic Circuit. Zeng Y, Jones AM, Thomas EE, Nassif B, Silberg JJ, Segatori L. ACS Synth Biol. 2018 Sep 21;7(9):2126-2138. doi: 10.1021/acssynbio.8b00129. Epub 2018 Aug 23. PubMed
TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy. Jena KK, Kolapalli SP, Mehto S, Nath P, Das B, Sahoo PK, Ahad A, Syed GH, Raghav SK, Senapati S, Chauhan S, Chauhan S. EMBO J. 2018 Sep 14;37(18). pii: embj.201798358. doi: 10.15252/embj.201798358. Epub 2018 Aug 24. PubMed
Heat shock promotes inclusion body formation of mutant huntingtin (mHtt) and alleviates mHtt-induced transcription factor dysfunction. Chen JY, Parekh M, Seliman H, Bakshinskaya D, Dai W, Kwan K, Chen KY, Liu AYC. J Biol Chem. 2018 Oct 5;293(40):15581-15593. doi: 10.1074/jbc.RA118.002933. Epub 2018 Aug 24. PubMed
GLP-1 Analogue Liraglutide Attenuates Mutant Huntingtin-Induced Neurotoxicity by Restoration of Neuronal Insulin Signaling. Chang CC, Lin TC, Ho HL, Kuo CY, Li HH, Korolenko TA, Chen WJ, Lai TJ, Ho YJ, Lin CL. Int J Mol Sci. 2018 Aug 24;19(9). pii: ijms19092505. doi: 10.3390/ijms19092505. PubMed
Mitochondrial superoxide generation induces a parkinsonian phenotype in zebrafish and huntingtin aggregation in human cells. Pinho BR, Reis SD, Hartley RC, Murphy MP, Oliveira JMA. Free Radic Biol Med. 2019 Jan;130:318-327. doi: 10.1016/j.freeradbiomed.2018.10.446. Epub 2018 Oct 31. PubMed
The sensitivity to Hsp90 inhibitors of both normal and oncogenically transformed cells is determined by the equilibrium between cellular quiescence and activity. Echeverria PC, Bhattacharya K, Joshi A, Wang T, Picard D. PLoS One. 2019 Feb 6;14(2):e0208287. doi: 10.1371/journal.pone.0208287. eCollection 2019. PubMed
Phosphorylated NUB1 distinguishes alpha-synuclein in Lewy bodies from that in glial cytoplasmic inclusions in multiple system atrophy. Tanji K, Miki Y, Mori F, Kon T, Kakita A, Takahashi H, Wakabayashi K. Brain Pathol. 2019 Apr 21. doi: 10.1111/bpa.12728. PubMed
Molecular mechanisms of heterogeneous oligomerization of huntingtin proteins. Bonfanti S, Lionetti MC, Fumagalli MR, Chirasani VR, Tiana G, Dokholyan NV, Zapperi S, La Porta CAM. Sci Rep. 2019 May 20;9(1):7615. doi: 10.1038/s41598-019-44151-0. PubMed
The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington's disease. Nobrega C, Conceicao A, Costa RG, Koppenol R, Sequeira RL, Nunes R, Carmo-Silva S, Marcelo A, Matos CA, Betuing S, Caboche J, Cartier N, Alves S. BMC Res Notes. 2020 Apr 10;13(1):210. doi: 10.1186/s13104-020-05053-x. PubMed
MEF2 impairment underlies skeletal muscle atrophy in polyglutamine disease. Nath SR, Lieberman ML, Yu Z, Marchioretti C, Jones ST, Danby ECE, Van Pelt KM, Soraru G, Robins DM, Bates GP, Pennuto M, Lieberman AP. Acta Neuropathol. 2020 Jul;140(1):63-80. doi: 10.1007/s00401-020-02156-4. Epub 2020 Apr 18. PubMed
ATP and spontaneous calcium oscillations control neural stem cell fate determination in Huntington's disease: a novel approach for cell clock research. Glaser T, Shimojo H, Ribeiro DE, Martins PPL, Beco RP, Kosinski M, Sampaio VFA, Correa-Velloso J, Oliveira-Giacomelli A, Lameu C, de Jesus Santos AP, de Souza HDN, Teng YD, Kageyama R, Ulrich H. Mol Psychiatry. 2020 Apr 29. pii: 10.1038/s41380-020-0717-5. doi: 10.1038/s41380-020-0717-5. PubMed
Co-chaperones DNAJA1 and DNAJB6 are critical for regulation of polyglutamine aggregation. Rodriguez-Gonzalez C, Lin S, Arkan S, Hansen C. Sci Rep. 2020 May 18;10(1):8130. doi: 10.1038/s41598-020-65046-5. PubMed

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