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Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras.
Wang T, Yu H, Hughes NW, Liu B, Kendirli A, Klein K, Chen WW, Lander ES, Sabatini DM
Cell. 2017 Feb 1. pii: S0092-8674(17)30061-2. doi: 10.1016/j.cell.2017.01.013.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
86122pMXs-HA-C1orf27Retroviral vector expressing HA-C1orf27-IRES-Bsd
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86124pMXs-RAP2A-GFPRetroviral vector expressing RAP2A-GFP-IRES-Bsd
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86125pMXs-NDUFAF5-HARetroviral vector expressing NDUFAF5-HA-IRES-Bsd
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86127LentiCRISPR-sgPREX1Lentiviral vector expressing Cas9 and an sgRNA targeting PREX1
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86128LentiCRISPR-sgSHOC2-1Lentiviral vector expressing Cas9 and an sgRNA targeting SHOC2
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86129LentiCRISPR-sgSHOC2-2Lentiviral vector expressing Cas9 and an sgRNA targeting SHOC2
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86130LentiCRISPR-sgC1orf27-1Lentiviral vector expressing Cas9 and an sgRNA targeting C1orf27
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86131LentiCRISPR-sgC1orf27-2Lentiviral vector expressing Cas9 and an sgRNA targeting C1orf27
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86132LentiCRISPR-sgUBA5Lentiviral vector expressing Cas9 and an sgRNA targeting UBA5
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86133LentiCRISPR-sgUFM1Lentiviral vector expressing Cas9 and an sgRNA targeting UFM1
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86134LentiCRISPR-sgUFSP2Lentiviral vector expressing Cas9 and an sgRNA targeting UFSP2
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86135LentiCRISPR-sgC17orf89-2Lentiviral vector expressing Cas9 and an sgRNA targeting C17orf89
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86136LentiCRISPR-sgC17orf89-3Lentiviral vector expressing Cas9 and an sgRNA targeting C17orf89
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86137LentiCRISPR-sgC17orf89-1Lentiviral vector expressing Cas9 and an sgRNA targeting C17orf89
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86138pMXs2-RAC1Retrolviral vector expressing RAC1-IRES-Bsd-p2A-RFP
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86139pMXs2-RAC1 G12VRetroviral vector expressing RAC1(G12V)-IRES-Bsd-p2A-RFP
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86141pMXs2-MEK1Retroviral vector expressing MEK1-IRES-Bsd-p2A-RFP
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86143pMXs3-TIAM1Retroviral vector expressing TIAM1-IRES-RFP
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86144pMXs3-NRAS G13DRetroviral vector expressing NRAS(G13D)-IRES-RFP
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86145pLenti-Cas9-GFPLentiviral vector expressing Cas9-GFP
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92352Sabatini/Lander Lab Ras synthetic lethal candidate focused human sgRNA library in lentiCRISPRv1contains 6,661 sgRNAs (comprising 499 intergenic control sgRNAs and 6,162 sgRNAs targeting 132 control and candidate Ras synthetic lethal genes at up to 50 sgRNAs per gene)
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