pCMV6M-Pak1 Citations (16)

Originally described in: Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells.
Sells MA, Knaus UG, Bagrodia S, Ambrose DM, Bokoch GM, Chernoff J Curr Biol. 1997 Mar 1. 7(3):202-10. PubMed Journal

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Articles Citing pCMV6M-Pak1

Articles
COX-2 promoter activation by AT1R-Gq-PAK-p38beta signaling in intestinal epithelial cells. Pham H, Vincenti R, Slice LW. Biochim Biophys Acta. 2008 Jun-Jul;1779(6-7):408-13. doi: 10.1016/j.bbagrm.2008.05.004. Epub 2008 May 13. PubMed
Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor-positive breast cancer cells. Long JS, Edwards J, Watson C, Tovey S, Mair KM, Schiff R, Natarajan V, Pyne NJ, Pyne S. Mol Cell Biol. 2010 Aug;30(15):3827-41. doi: 10.1128/MCB.01133-09. Epub 2010 Jun 1. PubMed
Quercetin inhibits HGF/c-Met signaling and HGF-stimulated melanoma cell migration and invasion. Cao HH, Cheng CY, Su T, Fu XQ, Guo H, Li T, Tse AK, Kwan HY, Yu H, Yu ZL. Mol Cancer. 2015 May 14;14:103. doi: 10.1186/s12943-015-0367-4. PubMed
PAK1 is involved in sensing the orientation of collagen stiffness gradients in mouse fibroblasts. Pinto VI, Mohammadi H, Lee WS, Cheung A, McCulloch CA. Biochim Biophys Acta. 2015 May 27. pii: S0167-4889(15)00173-1. doi: 10.1016/j.bbamcr.2015.05.019. PubMed
Suppression of Nkx3.2 by phosphatidylinositol-3-kinase signaling regulates cartilage development by modulating chondrocyte hypertrophy. Kim JA, Im S, Cantley LC, Kim DW. Cell Signal. 2015 Dec;27(12):2389-400. doi: 10.1016/j.cellsig.2015.09.004. Epub 2015 Sep 9. PubMed
p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase. Barrows D, Schoenfeld SM, Hodakoski C, Silkov A, Honig B, Couvillon A, Shymanets A, Nurnberg B, Asara JM, Parsons R. J Biol Chem. 2015 Nov 27;290(48):28915-31. doi: 10.1074/jbc.M115.668244. Epub 2015 Oct 5. PubMed
p27(Kip1) promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway. Jeannot P, Nowosad A, Perchey RT, Callot C, Bennana E, Katsube T, Mayeux P, Guillonneau F, Manenti S, Besson A. Elife. 2017 Mar 13;6. doi: 10.7554/eLife.22207. PubMed
Protein kinase D1 (PKD1) phosphorylation on Ser203 by type I p21-activated kinase (PAK) regulates PKD1 localization. Chang JK, Ni Y, Han L, Sinnett-Smith J, Jacamo R, Rey O, Young SH, Rozengurt E. J Biol Chem. 2017 Jun 9;292(23):9523-9539. doi: 10.1074/jbc.M116.771394. Epub 2017 Apr 13. PubMed
PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in spinocerebellar ataxia type 1. Bondar VV, Adamski CJ, Onur TS, Tan Q, Wang L, Diaz-Garcia J, Park J, Orr HT, Botas J, Zoghbi HY. Hum Mol Genet. 2018 Aug 15;27(16):2863-2873. doi: 10.1093/hmg/ddy200. PubMed
Pathogenic Escherichia coli Hijacks GTPase-Activated p21-Activated Kinase for Actin Pedestal Formation. Singh V, Davidson A, Hume PJ, Koronakis V. mBio. 2019 Aug 20;10(4). pii: mBio.01876-19. doi: 10.1128/mBio.01876-19. PubMed
Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5. Feng X, Zhang H, Meng L, Song H, Zhou Q, Qu C, Zhao P, Li Q, Zou C, Liu X, Zhang Z. Autophagy. 2021 Mar;17(3):723-742. doi: 10.1080/15548627.2020.1731266. Epub 2020 Mar 18. PubMed
PAK1 Regulates MEC-17 Acetyltransferase Activity and Microtubule Acetylation during Proplatelet Extension. van Dijk J, Bompard G, Rabeharivelo G, Cau J, Delsert C, Morin N. Int J Mol Sci. 2020 Oct 13;21(20):7531. doi: 10.3390/ijms21207531. PubMed
Vimentin tunes cell migration on collagen by controlling beta1 integrin activation and clustering. Ostrowska-Podhorodecka Z, Ding I, Lee W, Tanic J, Abbasi S, Arora PD, Liu RS, Patteson AE, Janmey PA, McCulloch CA. J Cell Sci. 2021 Mar 29;134(6). pii: jcs.254359. doi: 10.1242/jcs.254359. PubMed
PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding. Soares AC, Ferreira A, Marien J, Delay C, Lee E, Trojanowski JQ, Moechars D, Annaert W, De Muynck L. J Biol Chem. 2021 Jan-Jun;296:100636. doi: 10.1016/j.jbc.2021.100636. Epub 2021 Apr 6. PubMed
p21-Activated Kinase 1 Promotes Breast Tumorigenesis via Phosphorylation and Activation of the Calcium/Calmodulin-Dependent Protein Kinase II. Saldivar-Ceron HI, Villamar-Cruz O, Wells CM, Oguz I, Spaggiari F, Chernoff J, Patino-Lopez G, Huerta-Yepez S, Montecillo-Aguado M, Rivera-Pazos CM, Loza-Mejia MA, Vivar-Sierra A, Briseno-Diaz P, Zentella-Dehesa A, Leon-Del-Rio A, Lopez-Saavedra A, Padierna-Mota L, Ibarra-Sanchez MJ, Esparza-Lopez J, Hernandez-Rivas R, Arias-Romero LE. Front Cell Dev Biol. 2022 Jan 17;9:759259. doi: 10.3389/fcell.2021.759259. eCollection 2021. PubMed
Development and Utility of a PAK1-Selective Degrader. Chow HY, Karchugina S, Groendyke BJ, Toenjes S, Hatcher J, Donovan KA, Fischer ES, Abalakov G, Faezov B, Dunbrack R, Gray NS, Chernoff J. J Med Chem. 2022 Dec 8;65(23):15627-15641. doi: 10.1021/acs.jmedchem.2c00756. Epub 2022 Nov 23. PubMed

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