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HA-Akt DN (K179M) Citations (13)

Originally described in: HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway.
Zhou BP, Hu MC, Miller SA, Yu Z, Xia W, Lin SY, Hung MC J Biol Chem. 2000 Mar 17. 275(11):8027-31.
PubMed Journal

Articles Citing HA-Akt DN (K179M)

Activation of phosphatidylinositol 3-kinase/Akt and impairment of nuclear factor-kappaB: molecular mechanisms behind the arrested maturation/activation state of Leishmania infantum-infected dendritic cells. Neves BM, Silvestre R, Resende M, Ouaissi A, Cunha J, Tavares J, Loureiro I, Santarem N, Silva AM, Lopes MC, Cruz MT, Cordeiro da Silva A. Am J Pathol. 2010 Dec;177(6):2898-911. doi: 10.2353/ajpath.2010.100367. Epub 2010 Oct 29. PubMed
Vinexin-beta protects against cardiac hypertrophy by blocking the Akt-dependent signalling pathway. Chen K, Gao L, Liu Y, Zhang Y, Jiang DS, Wei X, Zhu XH, Zhang R, Chen Y, Yang Q, Kioka N, Zhang XD, Li H. Basic Res Cardiol. 2013 Mar;108(2):338. doi: 10.1007/s00395-013-0338-0. Epub 2013 Feb 22. PubMed
Akt isoforms differentially protect against stroke-induced neuronal injury by regulating mTOR activities. Xie R, Cheng M, Li M, Xiong X, Daadi M, Sapolsky RM, Zhao H. J Cereb Blood Flow Metab. 2013 Dec;33(12):1875-85. doi: 10.1038/jcbfm.2013.132. Epub 2013 Aug 14. PubMed

Associated Plasmids

Light activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotection. Rajala A, Gupta VK, Anderson RE, Rajala RV. Mitochondrion. 2013 Nov;13(6):566-76. doi: 10.1016/j.mito.2013.08.005. Epub 2013 Aug 30. PubMed
The T-box transcription factor, TBX3, is a key substrate of AKT3 in melanomagenesis. Peres J, Mowla S, Prince S. Oncotarget. 2015 Jan 30;6(3):1821-33. PubMed
Integrin alpha6beta1 Expressed in ESCs Instructs the Differentiation to Endothelial Cells. Toya SP, Wary KK, Mittal M, Li F, Toth PT, Park C, Rehman J, Malik AB. Stem Cells. 2015 Jun;33(6):1719-29. doi: 10.1002/stem.1974. PubMed
Apigenin inhibits cell proliferation, migration, and invasion by targeting Akt in the A549 human lung cancer cell line. Zhou Z, Tang M, Liu Y, Zhang Z, Lu R, Lu J. Anticancer Drugs. 2017 Apr;28(4):446-456. doi: 10.1097/CAD.0000000000000479. PubMed
CSF-1-induced Src signaling can instruct monocytic lineage choice. Endele M, Loeffler D, Kokkaliaris KD, Hilsenbeck O, Skylaki S, Hoppe PS, Schambach A, Stanley ER, Schroeder T. Blood. 2017 Mar 23;129(12):1691-1701. doi: 10.1182/blood-2016-05-714329. Epub 2017 Feb 3. PubMed
Transcription factor Foxo1 is essential for IL-9 induction in T helper cells. Malik S, Sadhu S, Elesela S, Pandey RP, Chawla AS, Sharma D, Panda L, Rathore D, Ghosh B, Ahuja V, Awasthi A. Nat Commun. 2017 Oct 9;8(1):815. doi: 10.1038/s41467-017-00674-6. PubMed
REDD1 Activates a ROS-Generating Feedback Loop in the Retina of Diabetic Mice. Miller WP, Toro AL, Barber AJ, Dennis MD. Invest Ophthalmol Vis Sci. 2019 May 1;60(6):2369-2379. doi: 10.1167/iovs.19-26606. PubMed
Simultaneously inactivating Src and AKT by saracatinib/capivasertib co-delivery nanoparticles to improve the efficacy of anti-Src therapy in head and neck squamous cell carcinoma. Lang L, Shay C, Zhao X, Xiong Y, Wang X, Teng Y. J Hematol Oncol. 2019 Dec 5;12(1):132. doi: 10.1186/s13045-019-0827-1. PubMed
Loss of melusin is a novel, neuronal NO synthase/FoxO3-independent master switch of unloading-induced muscle atrophy. Vitadello M, Sorge M, Percivalle E, Germinario E, Danieli-Betto D, Turco E, Tarone G, Brancaccio M, Gorza L. J Cachexia Sarcopenia Muscle. 2020 Jun;11(3):802-819. doi: 10.1002/jcsm.12546. Epub 2020 Mar 10. PubMed
Small-molecule Akt-activation in airway cells induces NO production and reduces IL-8 transcription through Nrf-2. Gopallawa I, Kuek LE, Adappa ND, Palmer JN, Lee RJ. Respir Res. 2021 Oct 19;22(1):267. doi: 10.1186/s12931-021-01865-y. PubMed

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