PG13-luc (wt p53 binding sites) Citations (45)

Originally described in: WAF1, a potential mediator of p53 tumor suppression.
el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B Cell. 1993 Nov 19. 75(4):817-25. PubMed Journal

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Articles Citing PG13-luc (wt p53 binding sites)

Articles
Enhancement of imatinib-induced apoptosis of BCR/ABL-expressing cells by nutlin-3 through synergistic activation of the mitochondrial apoptotic pathway. Kurosu T, Wu N, Oshikawa G, Kagechika H, Miura O. Apoptosis. 2010 May;15(5):608-20. doi: 10.1007/s10495-010-0457-0. PubMed
Novel tumor growth inhibition mechanism by cell cycle regulator cdk2ap1 involves antiangiogenesis modulation. Zolochevska O, Figueiredo ML. Microvasc Res. 2010 Dec;80(3):324-31. doi: 10.1016/j.mvr.2010.06.001. Epub 2010 Jun 10. PubMed
Hairless expression attenuates apoptosis in a mouse model and the COS cell line; involvement of p53. O'Driscoll C, Bressler JP. PLoS One. 2010 Sep 23;5(9):e12911. doi: 10.1371/journal.pone.0012911. PubMed
Naturally occurring germline and tumor-associated mutations within the ATP-binding motifs of PTEN lead to oxidative damage of DNA associated with decreased nuclear p53. He X, Ni Y, Wang Y, Romigh T, Eng C. Hum Mol Genet. 2011 Jan 1;20(1):80-9. doi: 10.1093/hmg/ddq434. Epub 2010 Oct 6. PubMed
p53 in trichostatin A induced C6 glioma cell death. Hsu YF, Sheu JR, Hsiao G, Lin CH, Chang TH, Chiu PT, Wang CY, Hsu MJ. Biochim Biophys Acta. 2011 May;1810(5):504-13. doi: 10.1016/j.bbagen.2011.02.006. Epub 2011 Mar 2. PubMed
PKCzeta mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation. Heo KS, Lee H, Nigro P, Thomas T, Le NT, Chang E, McClain C, Reinhart-King CA, King MR, Berk BC, Fujiwara K, Woo CH, Abe J. J Cell Biol. 2011 May 30;193(5):867-84. doi: 10.1083/jcb.201010051. PubMed
p53-Independent expression of wild-type p53-induced phosphatase 1 (Wip1) in methylmethane sulfonate-treated cancer cell lines and human tumors. Park JY, Song JY, Kim HM, Han HS, Seol HS, Jang SJ, Choi J. Int J Biochem Cell Biol. 2012 Jun;44(6):896-904. doi: 10.1016/j.biocel.2012.02.013. Epub 2012 Feb 24. PubMed
Identification of HEXIM1 as a positive regulator of p53. Lew QJ, Chia YL, Chu KL, Lam YT, Gurumurthy M, Xu S, Lam KP, Cheong N, Chao SH. J Biol Chem. 2012 Oct 19;287(43):36443-54. doi: 10.1074/jbc.M112.374157. Epub 2012 Sep 4. PubMed
Inhibition of autophagy via p53-mediated disruption of ULK1 in a SCA7 polyglutamine disease model. Yu X, Munoz-Alarcon A, Ajayi A, Webling KE, Steinhof A, Langel U, Strom AL. J Mol Neurosci. 2013 Jul;50(3):586-99. doi: 10.1007/s12031-013-0012-x. Epub 2013 Apr 18. PubMed
Plakoglobin interacts with the transcription factor p53 and regulates the expression of 14-3-3sigma. Aktary Z, Kulak S, Mackey J, Jahroudi N, Pasdar M. J Cell Sci. 2013 Jul 15;126(Pt 14):3031-42. doi: 10.1242/jcs.120642. Epub 2013 May 17. PubMed
Classification of a frameshift/extended and a stop mutation in WT1 as gain-of-function mutations that activate cell cycle genes and promote Wilms tumour cell proliferation. Busch M, Schwindt H, Brandt A, Beier M, Gorldt N, Romaniuk P, Toska E, Roberts S, Royer HD, Royer-Pokora B. Hum Mol Genet. 2014 Aug 1;23(15):3958-74. doi: 10.1093/hmg/ddu111. Epub 2014 Mar 11. PubMed
Proline, glutamic acid and leucine-rich protein-1 is essential for optimal p53-mediated DNA damage response. Nair BC, Krishnan SR, Sareddy GR, Mann M, Xu B, Natarajan M, Hasty P, Brann D, Tekmal RR, Vadlamudi RK. Cell Death Differ. 2014 Sep;21(9):1409-18. doi: 10.1038/cdd.2014.55. Epub 2014 May 2. PubMed
Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells. Shim HS, Wei M, Brandhorst S, Longo VD. Cancer Res. 2015 Mar 15;75(6):1056-67. doi: 10.1158/0008-5472.CAN-14-2249. Epub 2015 Jan 22. PubMed
PATZ1 Is a DNA Damage-Responsive Transcription Factor That Inhibits p53 Function. Keskin N, Deniz E, Eryilmaz J, Un M, Batur T, Ersahin T, Cetin Atalay R, Sakaguchi S, Ellmeier W, Erman B. Mol Cell Biol. 2015 May;35(10):1741-53. doi: 10.1128/MCB.01475-14. Epub 2015 Mar 9. PubMed
Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1-p53 signaling pathways. Wang Y, Jiang Y, Fan X, Tan H, Zeng H, Wang Y, Chen P, Huang M, Bi H. Toxicol Lett. 2015 Jul 16;236(2):82-9. doi: 10.1016/j.toxlet.2015.05.001. Epub 2015 May 5. PubMed
Lafora disease proteins laforin and malin negatively regulate the HIPK2-p53 cell death pathway. Upadhyay M, Gupta S, Bhadauriya P, Ganesh S. Biochem Biophys Res Commun. 2015 Aug 14;464(1):106-11. doi: 10.1016/j.bbrc.2015.06.018. Epub 2015 Jun 21. PubMed
Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1. Lee WY, Lee WT, Cheng CH, Chen KC, Chou CM, Chung CH, Sun MS, Cheng HW, Ho MN, Lin CW. Oncotarget. 2015 Sep 29;6(29):27580-95. doi: 10.18632/oncotarget.4768. PubMed
Human T-cell leukemia virus type-1-encoded protein HBZ represses p53 function by inhibiting the acetyltransferase activity of p300/CBP and HBO1. Wright DG, Marchal C, Hoang K, Ankney JA, Nguyen ST, Rushing AW, Polakowski N, Miotto B, Lemasson I. Oncotarget. 2016 Jan 12;7(2):1687-706. doi: 10.18632/oncotarget.6424. PubMed
Heat shock modulates the subcellular localization, stability, and activity of HIPK2. Upadhyay M, Bhadauriya P, Ganesh S. Biochem Biophys Res Commun. 2016 Apr 15;472(4):580-4. doi: 10.1016/j.bbrc.2016.03.035. Epub 2016 Mar 10. PubMed
Down regulation of Chk1 by p53 plays a role in synergistic induction of apoptosis by chemotherapeutics and inhibitors for Jak2 or BCR/ABL in hematopoietic cells. Umezawa Y, Kurosu T, Akiyama H, Wu N, Nogami A, Nagao T, Miura O. Oncotarget. 2016 Jul 12;7(28):44448-44461. doi: 10.18632/oncotarget.9844. PubMed
RECQ1 expression is upregulated in response to DNA damage and in a p53-dependent manner. Parvathaneni S, Lu X, Chaudhary R, Lal A, Madhusudan S, Sharma S. Oncotarget. 2017 May 27. doi: 10.18632/oncotarget.18237. PubMed
Exploring the Human-Nipah Virus Protein-Protein Interactome. Martinez-Gil L, Vera-Velasco NM, Mingarro I. J Virol. 2017 Nov 14;91(23). pii: JVI.01461-17. doi: 10.1128/JVI.01461-17. Print 2017 Dec 1. PubMed
RECQ1 expression is upregulated in response to DNA damage and in a p53-dependent manner. Parvathaneni S, Lu X, Chaudhary R, Lal A, Madhusudan S, Sharma S. Oncotarget. 2017 May 27;8(44):75924-75942. doi: 10.18632/oncotarget.18237. eCollection 2017 Sep 29. PubMed
PEPD is a pivotal regulator of p53 tumor suppressor. Yang L, Li Y, Bhattacharya A, Zhang Y. Nat Commun. 2017 Dec 12;8(1):2052. doi: 10.1038/s41467-017-02097-9. PubMed
A Combination of SAHA and Quinacrine Is Effective in Inducing Cancer Cell Death in Upper Gastrointestinal Cancers. Zhu S, Chen Z, Wang L, Peng D, Belkhiri A, Lockhart AC, El-Rifai W. Clin Cancer Res. 2018 Apr 15;24(8):1905-1916. doi: 10.1158/1078-0432.CCR-17-1716. Epub 2018 Jan 31. PubMed
Targeting of PP2Cdelta By a Small Molecule C23 Inhibits High Glucose-Induced Breast Cancer Progression In Vivo. Wu K, Yu X, Huang Z, Zhu D, Yi X, Wu YL, Hao Q, Kemp KT 2nd, Elshimali Y, Iyer R, Nguyen KT, Zheng S, Chen G, Chen QH, Wang G, Vadgama JV, Wu Y. Antioxid Redox Signal. 2019 Jun 10;30(17):1983-1998. doi: 10.1089/ars.2017.7486. Epub 2018 Jul 13. PubMed
A tight balance of Karyopherin beta1 expression is required in cervical cancer cells. Carden S, van der Watt P, Chi A, Ajayi-Smith A, Hadley K, Leaner VD. BMC Cancer. 2018 Nov 16;18(1):1123. doi: 10.1186/s12885-018-5044-8. PubMed
Estrogen therapy induces an unfolded protein response to drive cell death in ER+ breast cancer. Hosford SR, Shee K, Wells JD, Traphagen NA, Fields JL, Hampsch RA, Kettenbach AN, Demidenko E, Miller TW. Mol Oncol. 2019 Aug;13(8):1778-1794. doi: 10.1002/1878-0261.12528. Epub 2019 Jul 9. PubMed
PP2Cdelta inhibits p300-mediated p53 acetylation via ATM/BRCA1 pathway to impede DNA damage response in breast cancer. Li Q, Hao Q, Cao W, Li J, Wu K, Elshimali Y, Zhu D, Chen QH, Chen G, Pollack JR, Vadgama J, Wu Y. Sci Adv. 2019 Oct 16;5(10):eaaw8417. doi: 10.1126/sciadv.aaw8417. eCollection 2019 Oct. PubMed
Nucleotide depletion reveals the impaired ribosome biogenesis checkpoint as a barrier against DNA damage. Pelletier J, Riano-Canalias F, Almacellas E, Mauvezin C, Samino S, Feu S, Menoyo S, Domostegui A, Garcia-Cajide M, Salazar R, Cortes C, Marcos R, Tauler A, Yanes O, Agell N, Kozma SC, Gentilella A, Thomas G. EMBO J. 2020 Jul 1;39(13):e103838. doi: 10.15252/embj.2019103838. Epub 2020 Jun 2. PubMed
Murine Cytomegalovirus M25 Proteins Sequester the Tumor Suppressor Protein p53 in Nuclear Accumulations. Kutle I, Szymanska-de Wijs KM, Bogdanow B, Cuvalo B, Steinbruck L, Jonjic S, Wagner K, Niedenthal R, Selbach M, Wiebusch L, Dezeljin M, Messerle M. J Virol. 2020 Sep 29;94(20):e00574-20. doi: 10.1128/JVI.00574-20. Print 2020 Sep 29. PubMed
Identification of miPEP133 as a novel tumor-suppressor microprotein encoded by miR-34a pri-miRNA. Kang M, Tang B, Li J, Zhou Z, Liu K, Wang R, Jiang Z, Bi F, Patrick D, Kim D, Mitra AK, Yang-Hartwich Y. Mol Cancer. 2020 Sep 14;19(1):143. doi: 10.1186/s12943-020-01248-9. PubMed
Inhibition of Kpnbeta1 mediated nuclear import enhances cisplatin chemosensitivity in cervical cancer. Chi RA, van der Watt P, Wei W, Birrer MJ, Leaner VD. BMC Cancer. 2021 Feb 2;21(1):106. doi: 10.1186/s12885-021-07819-3. PubMed
USP42 protects ZNRF3/RNF43 from R-spondin-dependent clearance and inhibits Wnt signalling. Giebel N, de Jaime-Soguero A, Garcia Del Arco A, Landry JJM, Tietje M, Villacorta L, Benes V, Fernandez-Saiz V, Acebron SP. EMBO Rep. 2021 May 5;22(5):e51415. doi: 10.15252/embr.202051415. Epub 2021 Mar 30. PubMed
Inhibition of nonsense-mediated decay rescues p53beta/gamma isoform expression and activates the p53 pathway in MDM2-overexpressing and select p53-mutant cancers. Gudikote JP, Cascone T, Poteete A, Sitthideatphaiboon P, Wu Q, Morikawa N, Zhang F, Peng S, Tong P, Li L, Shen L, Nilsson M, Jones P, Sulman EP, Wang J, Bourdon JC, Johnson FM, Heymach JV. J Biol Chem. 2021 Nov;297(5):101163. doi: 10.1016/j.jbc.2021.101163. Epub 2021 Sep 3. PubMed
Autophagy inhibition mediated by MCOLN1/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53/p53 pathway. Xing Y, Wei X, Liu Y, Wang MM, Sui Z, Wang X, Zhu W, Wu M, Lu C, Fei YH, Jiang Y, Zhang Y, Wang Y, Guo F, Cao JL, Qi J, Wang W. Autophagy. 2022 Aug;18(8):1932-1954. doi: 10.1080/15548627.2021.2008752. Epub 2021 Dec 8. PubMed
Pharmacological CDK4/6 inhibition reveals a p53-dependent senescent state with restricted toxicity. Wang B, Varela-Eirin M, Brandenburg SM, Hernandez-Segura A, van Vliet T, Jongbloed EM, Wilting SM, Ohtani N, Jager A, Demaria M. EMBO J. 2022 Mar 15;41(6):e108946. doi: 10.15252/embj.2021108946. Epub 2022 Jan 5. PubMed
Unprotected peptide macrocyclization and stapling via a fluorine-thiol displacement reaction. Islam MS, Junod SL, Zhang S, Buuh ZY, Guan Y, Zhao M, Kaneria KH, Kafley P, Cohen C, Maloney R, Lyu Z, Voelz VA, Yang W, Wang RE. Nat Commun. 2022 Jan 17;13(1):350. doi: 10.1038/s41467-022-27995-5. PubMed
A noninvasive iRFP713 p53 reporter reveals dynamic p53 activity in response to irradiation and liver regeneration in vivo. Humpton TJ, Hock AK, Kiourtis C, De Donatis M, Fercoq F, Nixon C, Bryson S, Strathdee D, Carlin LM, Bird TG, Blyth K, Vousden KH. Sci Signal. 2022 Feb 8;15(720):eabd9099. doi: 10.1126/scisignal.abd9099. Epub 2022 Feb 8. PubMed
Zebrafish imaging reveals TP53 mutation switching oncogene-induced senescence from suppressor to driver in primary tumorigenesis. Haraoka Y, Akieda Y, Nagai Y, Mogi C, Ishitani T. Nat Commun. 2022 Mar 18;13(1):1417. doi: 10.1038/s41467-022-29061-6. PubMed
NF90-NF45 is essential for beta cell compensation under obesity-inducing metabolic stress through suppression of p53 signaling pathway. Lai S, Higuchi T, Tsuda M, Sugiyama Y, Morisawa K, Taniguchi T, Sakamoto S. Sci Rep. 2022 May 25;12(1):8837. doi: 10.1038/s41598-022-12600-y. PubMed
TRPML1-induced autophagy inhibition triggers mitochondrial mediated apoptosis. Liu Y, Wang X, Zhu W, Sui Z, Wei X, Zhang Y, Qi J, Xing Y, Wang W. Cancer Lett. 2022 Aug 10;541:215752. doi: 10.1016/j.canlet.2022.215752. Epub 2022 May 26. PubMed
Long non-coding RNA TILR constitutively represses TP53 and apoptosis in lung cancer. Iwai M, Kajino T, Nakatochi M, Yanagisawa K, Hosono Y, Isomura H, Shimada Y, Suzuki M, Taguchi A, Takahashi T. Oncogene. 2023 Jan;42(5):364-373. doi: 10.1038/s41388-022-02546-w. Epub 2022 Dec 15. PubMed
Elephant TP53-RETROGENE 9 induces transcription-independent apoptosis at the mitochondria. Preston AJ, Rogers A, Sharp M, Mitchell G, Toruno C, Barney BB, Donovan LN, Bly J, Kennington R, Payne E, Iovino A, Furukawa G, Robinson R, Shamloo B, Buccilli M, Anders R, Eckstein S, Fedak EA, Wright T, Maley CC, Kiso WK, Schmitt D, Malkin D, Schiffman JD, Abegglen LM. Cell Death Discov. 2023 Feb 16;9(1):66. doi: 10.1038/s41420-023-01348-7. PubMed
NUDT22 promotes cancer growth through pyrimidine salvage. Walter M, Mayr F, Hanna BMF, Cookson V, Mortusewicz O, Helleday T, Herr P. Oncogene. 2023 Apr;42(16):1282-1293. doi: 10.1038/s41388-023-02643-4. Epub 2023 Mar 4. PubMed

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