pcDNA3 HA-PHLPP1 full length Citations (6)

Originally described in: Mislocalization of the E3 ligase, beta-transducin repeat-containing protein 1 (beta-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt.
Warfel NA, Niederst M, Stevens MW, Brennan PM, Frame MC, Newton AC J Biol Chem. 2011 Jun 3;286(22):19777-88. Epub 2011 Mar 28. PubMed Journal

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Articles Citing pcDNA3 HA-PHLPP1 full length

Articles
Interactome of the negative regulator of nuclear import BRCA1-binding protein 2. Fatima S, Wagstaff KM, Loveland KL, Jans DA. Sci Rep. 2015 Mar 30;5:9459. doi: 10.1038/srep09459. PubMed
Tumor suppressor REIC/DKK-3 and co-chaperone SGTA: Their interaction and roles in the androgen sensitivity. Ochiai K, Morimatsu M, Kato Y, Ishiguro-Oonuma T, Udagawa C, Rungsuriyawiboon O, Azakami D, Michishita M, Ariyoshi Y, Ueki H, Nasu Y, Kumon H, Watanabe M, Omi T. Oncotarget. 2016 Jan 19;7(3):3283-96. doi: 10.18632/oncotarget.6488. PubMed
The tuberous sclerosis complex subunit TBC1D7 is stabilized by Akt phosphorylation-mediated 14-3-3 binding. Madigan JP, Hou F, Ye L, Hu J, Dong A, Tempel W, Yohe ME, Randazzo PA, Jenkins LMM, Gottesman MM, Tong Y. J Biol Chem. 2018 Oct 19;293(42):16142-16159. doi: 10.1074/jbc.RA118.003525. Epub 2018 Aug 24. PubMed
Inhibition of PHLPP1/2 phosphatases rescues pancreatic beta-cells in diabetes. Lupse B, Annamalai K, Ibrahim H, Kaur S, Geravandi S, Sarma B, Pal A, Awal S, Joshi A, Rafizadeh S, Madduri MK, Khazaei M, Liu H, Yuan T, He W, Gorrepati KDD, Azizi Z, Qi Q, Ye K, Oberholzer J, Maedler K, Ardestani A. Cell Rep. 2021 Aug 3;36(5):109490. doi: 10.1016/j.celrep.2021.109490. PubMed
PHLPP1 Overexpression was Associated With a Good Prognosis With Decreased AKT Activity in Gastric Cancer. Park SY, Jeong SH, Jung EJ, Ju YT, Jeong CY, Kim JY, Park T, Park J, Kim TH, Park M, Yang JW, Lee YJ. Technol Cancer Res Treat. 2022 Jan-Dec;21:15330338211067063. doi: 10.1177/15330338211067063. PubMed
FKBP51 plays an essential role in Akt ubiquitination that requires Hsp90 and PHLPP. Tufano M, Marrone L, D'Ambrosio C, Di Giacomo V, Urzini S, Xiao Y, Matuozzo M, Scaloni A, Romano MF, Romano S. Cell Death Dis. 2023 Feb 13;14(2):116. doi: 10.1038/s41419-023-05629-y. PubMed

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