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pOTTC293 - pAAV EF1a V5-synuclein (WT) Citations (5)

Originally described in: The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse.
Savolainen MH, Richie CT, Harvey BK, Mannisto PT, Maguire-Zeiss KA, Myohanen TT Neurobiol Dis. 2014 Aug;68:1-15. doi: 10.1016/j.nbd.2014.04.003. Epub 2014 Apr 16.
PubMed Journal

Articles Citing pOTTC293 - pAAV EF1a V5-synuclein (WT)

Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo. Svarcbahs R, Julku UH, Norrbacka S, Myohanen TT. Sci Rep. 2018 Jan 24;8(1):1552. doi: 10.1038/s41598-018-19823-y. PubMed
Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats. Back S, Necarsulmer J, Whitaker LR, Coke LM, Koivula P, Heathward EJ, Fortuno LV, Zhang Y, Yeh CG, Baldwin HA, Spencer MD, Mejias-Aponte CA, Pickel J, Hoffman AF, Spivak CE, Lupica CR, Underhill SM, Amara SG, Domanskyi A, Anttila JE, Airavaara M, Hope BT, Hamra FK, Richie CT, Harvey BK. Neuron. 2019 Feb 8. pii: S0896-6273(19)30062-5. doi: 10.1016/j.neuron.2019.01.035. PubMed

Associated Plasmids

Neuronal Activation Stimulates Cytomegalovirus Promoter-Driven Transgene Expression. Back S, Dossat A, Parkkinen I, Koivula P, Airavaara M, Richie CT, Chen YH, Wang Y, Harvey BK. Mol Ther Methods Clin Dev. 2019 Jul 3;14:180-188. doi: 10.1016/j.omtm.2019.06.006. eCollection 2019 Sep 13. PubMed
Prolyl Oligopeptidase Regulates Dopamine Transporter Oligomerization and Phosphorylation in a PKC- and ERK-Independent Manner. Julku UH, Jantti M, Svarcbahs R, Myohanen TT. Int J Mol Sci. 2021 Feb 10;22(4). pii: ijms22041777. doi: 10.3390/ijms22041777. PubMed
Prolyl oligopeptidase inhibition reduces alpha-synuclein aggregation in a cellular model of multiple system atrophy. Cui H, Kilpelainen T, Zouzoula L, Auno S, Trontti K, Kurvonen S, Norrbacka S, Hovatta I, Jensen PH, Myohanen TT. J Cell Mol Med. 2021 Oct;25(20):9634-9646. doi: 10.1111/jcmm.16910. Epub 2021 Sep 5. PubMed

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