pCDH-EF1-FHC-POLQ Citations (6)

Originally described in: Mechanism of suppression of chromosomal instability by DNA polymerase POLQ.
Yousefzadeh MJ, Wyatt DW, Takata K, Mu Y, Hensley SC, Tomida J, Bylund GO, Doublie S, Johansson E, Ramsden DA, McBride KM, Wood RD PLoS Genet. 2014 Oct 2;10(10):e1004654. doi: 10.1371/journal.pgen.1004654. eCollection 2014 Oct. PubMed Journal

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Articles Citing pCDH-EF1-FHC-POLQ

Articles
DNA polymerase theta (POLQ) is important for repair of DNA double-strand breaks caused by fork collapse. Wang Z, Song Y, Li S, Kurian S, Xiang R, Chiba T, Wu X. J Biol Chem. 2019 Mar 15;294(11):3909-3919. doi: 10.1074/jbc.RA118.005188. Epub 2019 Jan 17. PubMed
EMT Transcription Factor ZEB1 Represses the Mutagenic POLtheta-Mediated End-Joining Pathway in Breast Cancers. Prodhomme MK, Pommier RM, Franchet C, Fauvet F, Bergoglio V, Brousset P, Morel AP, Brunac AC, Devouassoux-Shisheboran M, Petrilli V, Moyret-Lalle C, Hoffmann JS, Puisieux A, Tissier A. Cancer Res. 2021 Mar 15;81(6):1595-1606. doi: 10.1158/0008-5472.CAN-20-2626. Epub 2020 Nov 25. PubMed
Poltheta promotes the repair of 5'-DNA-protein crosslinks by microhomology-mediated end-joining. Chandramouly G, Liao S, Rusanov T, Borisonnik N, Calbert ML, Kent T, Sullivan-Reed K, Vekariya U, Kashkina E, Skorski T, Yan H, Pomerantz RT. Cell Rep. 2021 Mar 9;34(10):108820. doi: 10.1016/j.celrep.2021.108820. PubMed
PARG is essential for Poltheta-mediated DNA end-joining by removing repressive poly-ADP-ribose marks. Vekariya U, Minakhin L, Chandramouly G, Tyagi M, Kent T, Sullivan-Reed K, Atkins J, Ralph D, Nieborowska-Skorska M, Kukuyan AM, Tang HY, Pomerantz RT, Skorski T. Nat Commun. 2024 Jul 11;15(1):5822. doi: 10.1038/s41467-024-50158-7. PubMed
Microhomology-mediated end joining acts directly on replication forks to repair single-ended double-strand breaks. Li S, Zhao Y, Li Y, Shah SB, Shi Y, Nguyen T, Wang Z, Chang CY, Ray A, Bu TH, Loguercio S, Sasaki T, Sussman JH, Wang H, Gilbert DM, Aladjem MI, Wu X. Mol Cell. 2026 Apr 2;86(7):1230-1246.e8. doi: 10.1016/j.molcel.2026.02.016. Epub 2026 Mar 16. PubMed
Poltheta activity modulates sensitivity to standard therapies in DNMT3A-deficient leukemia. Le BV, Vekariya U, Toma MM, Nieborowska-Skorska M, Caron MC, Gozdecka M, Haydar Z, Walsh M, Ghosh J, Vaughan-Williams E, Podszywalow-Bartnicka P, Kukuyan AM, Ziolkowska S, Atkins J, Hadzijusufovic E, Chandramouly G, Nejati R, Piwocka K, Pomerantz R, Vassiliou GS, Huntly BJP, Valent P, Wasik M, Bellacosa A, Masson JY, Gupta GP, Challen GA, Skorski T. Cell Rep Med. 2026 Mar 17;7(3):102687. doi: 10.1016/j.xcrm.2026.102687. PubMed

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