Skip to main content
This website uses cookies to ensure you get the best experience. By continuing to use this site, you agree to the use of cookies.

Addgene is open for ordering and depositing; find up-to-date details here. To learn more about how we are supporting COVID-19 research and to find related plasmids, check out our COVID-19 and Coronavirus Plasmids & Resources page.

Please note: Your browser does not support the features used on Addgene's website. You may not be able to create an account or request plasmids through this website until you upgrade your browser. Learn more

Please note: Your browser does not fully support some of the features used on Addgene's website. If you run into any problems registering, depositing, or ordering please contact us at [email protected] Learn more

pCI flag PCAF Citations (15)

Plasmid Article: A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A.
Yang XJ, Ogryzko VV, Nishikawa J, Howard BH, Nakatani Y Nature. 1996 Jul 25. 382(6589):319-24.
PubMed Journal

Articles Citing pCI flag PCAF

Articles
HDAC inhibition promotes neuronal outgrowth and counteracts growth cone collapse through CBP/p300 and P/CAF-dependent p53 acetylation. Gaub P, Tedeschi A, Puttagunta R, Nguyen T, Schmandke A, Di Giovanni S. Cell Death Differ. 2010 Sep;17(9):1392-408. doi: 10.1038/cdd.2009.216. Epub 2010 Jan 22. PubMed
Repression of interferon-alpha stimulated genes expression by Kaposi's sarcoma-associated herpesvirus K-bZIP protein. Lefort S, Gravel A, Flamand L. Virology. 2010 Dec 5;408(1):14-30. doi: 10.1016/j.virol.2010.07.027. Epub 2010 Sep 26. PubMed
Acetylation of a conserved lysine residue in the ATP binding pocket of p38 augments its kinase activity during hypertrophy of cardiomyocytes. Pillai VB, Sundaresan NR, Samant SA, Wolfgeher D, Trivedi CM, Gupta MP. Mol Cell Biol. 2011 Jun;31(11):2349-63. doi: 10.1128/MCB.01205-10. Epub 2011 Mar 28. PubMed
A novel function for p21Cip1 and acetyltransferase p/CAF as critical transcriptional regulators of TGFbeta-mediated breast cancer cell migration and invasion. Dai M, Al-Odaini AA, Arakelian A, Rabbani SA, Ali S, Lebrun JJ. Breast Cancer Res. 2012 Sep 20;14(5):R127. doi: 10.1186/bcr3322. PubMed
Glucagon-induced acetylation of Foxa2 regulates hepatic lipid metabolism. von Meyenn F, Porstmann T, Gasser E, Selevsek N, Schmidt A, Aebersold R, Stoffel M. Cell Metab. 2013 Mar 5;17(3):436-47. doi: 10.1016/j.cmet.2013.01.014. Epub 2013 Feb 14. PubMed
p300, but not PCAF, collaborates with IRF-1 in stimulating TRIM22 expression independently of its histone acetyltransferase activity. Gao B, Xu W, Zhong L, Zhang Q, Su Y, Xiong S. Eur J Immunol. 2013 Aug;43(8):2174-84. doi: 10.1002/eji.201343308. Epub 2013 Jun 12. PubMed
PCAF-dependent epigenetic changes promote axonal regeneration in the central nervous system. Puttagunta R, Tedeschi A, Soria MG, Hervera A, Lindner R, Rathore KI, Gaub P, Joshi Y, Nguyen T, Schmandke A, Laskowski CJ, Boutillier AL, Bradke F, Di Giovanni S. Nat Commun. 2014 Apr 1;5:3527. doi: 10.1038/ncomms4527. PubMed
SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. North BJ, Rosenberg MA, Jeganathan KB, Hafner AV, Michan S, Dai J, Baker DJ, Cen Y, Wu LE, Sauve AA, van Deursen JM, Rosenzweig A, Sinclair DA. EMBO J. 2014 Jul 1;33(13):1438-53. doi: 10.15252/embj.201386907. Epub 2014 May 12. PubMed
Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth. Sun T, Li X, Zhang P, Chen WD, Zhang HL, Li DD, Deng R, Qian XJ, Jiao L, Ji J, Li YT, Wu RY, Yu Y, Feng GK, Zhu XF. Nat Commun. 2015 May 26;6:7215. doi: 10.1038/ncomms8215. PubMed
Human T-cell leukemia virus type-1-encoded protein HBZ represses p53 function by inhibiting the acetyltransferase activity of p300/CBP and HBO1. Wright DG, Marchal C, Hoang K, Ankney JA, Nguyen ST, Rushing AW, Polakowski N, Miotto B, Lemasson I. Oncotarget. 2016 Jan 12;7(2):1687-706. doi: 10.18632/oncotarget.6424. PubMed
Wnt/beta-catenin-dependent acetylation of Pygo2 by CBP/p300 histone acetyltransferase family members. Andrews PG, Kao KR. Biochem J. 2016 Nov 15;473(22):4193-4203. Epub 2016 Sep 19. PubMed
Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis. Kikani CK, Wu X, Paul L, Sabic H, Shen Z, Shakya A, Keefe A, Villanueva C, Kardon G, Graves B, Tantin D, Rutter J. Elife. 2016 Sep 23;5. pii: e17985. doi: 10.7554/eLife.17985. PubMed
Sirtuin 7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR4. Karim MF, Yoshizawa T, Sobuz SU, Sato Y, Yamagata K. Biochem Biophys Res Commun. 2017 Aug 19;490(2):423-428. doi: 10.1016/j.bbrc.2017.06.057. Epub 2017 Jun 14. PubMed
P300/CBP-associated factor regulates transcription and function of isocitrate dehydrogenase 2 during muscle differentiation. Savoia M, Cencioni C, Mori M, Atlante S, Zaccagnini G, Devanna P, Di Marcotullio L, Botta B, Martelli F, Zeiher AM, Pontecorvi A, Farsetti A, Spallotta F, Gaetano C. FASEB J. 2019 Mar;33(3):4107-4123. doi: 10.1096/fj.201800788R. Epub 2018 Dec 10. PubMed
PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth. Cai W, Su L, Liao L, Liu ZZ, Langbein L, Dulaimi E, Testa JR, Uzzo RG, Zhong Z, Jiang W, Yan Q, Zhang Q, Yang H. Nat Commun. 2019 Dec 20;10(1):5800. doi: 10.1038/s41467-019-13608-1. PubMed

If you have published an article using this plasmid, please email us at [email protected] to have your article added to this page.