The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation.
Angers S, Thorpe CJ, Biechele TL, Goldenberg SJ, Zheng N, MacCoss MJ, Moon RT
Nat Cell Biol. 2006 Apr . 8(4):348-57.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 15100 | V51 pIRESpuro-GLUE (pGLUE) | tandem-affinity purification plasmid; streptavidin-(streptag) and calmodulin-(CBP) binding affinity tags |
| 15101 | M76 pIRESpuro-GLUE-hDsh2 | |
| 15102 | M77 pIRESpuro-GLUE-hDsh3 | |
| 16752 | XE257 pCDNA3.1(zeo)-hDsh3-truncDEP | |
| 16753 | XE256 pCDNA3.1(zeo)-hDsh3-deltaCTER | |
| 16754 | XE255 pCDNA3.1(zeo)-hDsh3-truncPDZ | |
| 16755 | XE254 pCDNA3.1(zeo)-hDsh3-497-716 | |
| 16756 | XE253 pCDNA3.1(zeo)-hDsh3-82-716 | |
| 16757 | XE252 pCDNA3.1(zeo)-hDsh3-333-716 | |
| 16758 | XE251 pCDNA3.1(zeo)-hDsh3 | |
| 16759 | XE250 pCDNA3.1 + (zeo)- VSV-KLHL12-Q405X | |
| 16761 | XE248 pCDNA3.1+zeo-VSV-KLHL12 | |
| 17132 | M78 pIRESpuro-CBP-2xTEV-StrepTag |