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A cell-based screening for TAZ activators identifies ethacridine, a widely used antiseptic and abortifacient, as a compound that promotes dephosphorylation of TAZ and inhibits adipogenesis in C3H10T1/2 cells.
Kawano S, Maruyama J, Nagashima S, Inami K, Qiu W, Iwasa H, Nakagawa K, Ishigami-Yuasa M, Kagechika H, Nishina H, Hata Y
J Biochem. 2015 May 14. pii: mvv051.
PubMed Article

Plasmids from Article

ID Plasmid Purpose
128348pCIneoLuc-PP1AVector for LUMIER assay
128349pCIneoLuc-PP2AVector for LUMIER assay
139648pLL3.7-K122-TEAD-p-H2B-mCherryReporter assay
139649pLL3.7-K122-FH-TAZ-TEAD-p-H2B-mCherryReporter assay

Antibodies from Article