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An inducible lentiviral guide RNA platform enables the identification of tumor-essential genes and tumor-promoting mutations in vivo.
Aubrey BJ, Kelly GL, Kueh AJ, Brennan MS, O'Connor L, Milla L, Wilcox S, Tai L, Strasser A, Herold MJ
Cell Rep. 2015 Mar 3;10(8):1422-32. doi: 10.1016/j.celrep.2015.02.002. Epub 2015 Feb 26.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
70182FUCas9CherryExpresses Cas9 with fluorescent Cherry reporter
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70183FgH1tUTGInducible expression of guide RNA with fluorescent GFP reporter
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85530FgH1tUTG_huMcl-1.1Inducible expression of guide RNA (huMcl-1.1) with fluorescent GFP reporter
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85531FgH1tUTG_huMcl-1.2Inducible expression of guide RNA (huMcl-1.2) with fluorescent GFP reporter
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85532FgH1tUTG_huBim_Ex3Inducible expression of guide RNA (huBim_Ex3) with fluorescent GFP reporter
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85533FgH1tUTG_muBim_Ex3Inducible expression of guide RNA (muBim_Ex3) with fluorescent GFP reporter
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85534FgH1tUTG_mup53_Ex4Inducible expression of guide RNA (mup53_Ex4) with fluorescent GFP reporter
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85535FgH1tUTG_mup53_Ex5Inducible expression of guide RNA (mup53_Ex5) with fluorescent GFP reporter
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