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Activation of concurrent apoptosis and necroptosis by SMAC mimetics for the treatment of refractory and relapsed ALL.

McComb S, Aguade-Gorgorio J, Harder L, Marovca B, Cario G, Eckert C, Schrappe M, Stanulla M, von Stackelberg A, Bourquin JP, Bornhauser BC
Sci Transl Med. 2016 May 18;8(339):339ra70. doi: 10.1126/scitranslmed.aad2986. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
75159pLentiCRISPR-EGFPDerived from LentiCRISPR v1 but expresses EGFP instead of puromycin resistance
75160pLentiCRISPR-tagBFPDerived from LentiCRISPR v1 but expresses tagBFP instead of puromycin resistance
75161pLentiCRISPR-mCherryDerived from LentiCRISPR v1 but expresses mCherry instead of puromycin resistance. 3rd generation.
75162pLentiCRISPR-RFP657Derived from LentiCRISPR v1 but expresses RFP657 instead of puromycin resistance
75163pLC-EGFP-RIP1LentiCRISPR-EGFP with sgRNA targeting human RIPk1
75164pLC-RFP657-CASP8LentiCRISPR-RFP657 with sgRNA targeting human Caspase-8
75165pLC-EGFP-RIP3LentiCRISPR-EGFP with sgRNA targeting human RIP3
75166pLC-BFP-FADDLentiCRISPR-BFP with sgRNA targeting human FADD
75167pLC-mCherry-MLKLLentiCRISPR-mCherry with sgRNA targeting human MLKL

Antibodies from Article