Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer.
Bell RJ, Rube HT, Kreig A, Mancini A, Fouse SD, Nagarajan RP, Choi S, Hong C, He D, Pekmezci M, Wiencke JK, Wrensch MR, Chang SM, Walsh KM, Myong S, Song JS, Costello JF
Science. 2015 May 29;348(6238):1036-9. doi: 10.1126/science.aab0015. Epub 2015 May 14. PubMed Article
Bell RJ, Rube HT, Kreig A, Mancini A, Fouse SD, Nagarajan RP, Choi S, Hong C, He D, Pekmezci M, Wiencke JK, Wrensch MR, Chang SM, Walsh KM, Myong S, Song JS, Costello JF
Science. 2015 May 29;348(6238):1036-9. doi: 10.1126/science.aab0015. Epub 2015 May 14. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 84924 | pGL4.0-TERT WT | luciferase reporter for TERT promoter |
| 84925 | pGL4.0-TERT G250A | luciferase reporter for mutant TERT promoter |
| 84926 | pGL4.0-TERT G228A | luciferase reporter for mutant TERT promoter |