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A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing.
Wang A, Conicella AE, Schmidt HB, Martin EW, Rhoads SN, Reeb AN, Nourse A, Ramirez Montero D, Ryan VH, Rohatgi R, Shewmaker F, Naik MT, Mittag T, Ayala YM, Fawzi NL
EMBO J. 2018 Mar 1;37(5). pii: embj.201797452. doi: 10.15252/embj.201797452. Epub 2018 Feb 9.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
104478TDP-43_NTD1-80_Y4Rbacterial expression of TDP-43 NTD Y4R
104479TDP-43_NTD1-80_E17Rbacterial expression of TDP-43 NTD E17R
104480pJ4M/TDP-43bacterial expression of TDP-43
104481pJ4M/TDP-43 S48Ebacterial expression of TDP-43 S48E

Recombinant Antibodies from Article