Evolved Cas9 variants with broad PAM compatibility and high DNA specificity.
Hu JH, Miller SM, Geurts MH, Tang W, Chen L, Sun N, Zeina CM, Gao X, Rees HA, Lin Z, Liu DR
Nature. 2018 Feb 28. pii: nature26155. doi: 10.1038/nature26155.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 108379 | xCas9 3.7 | Mammalian expression vector for xCas9 3.7 |
| 108380 | xCas9(3.7)-BE3 | Mammalian expression vector for xCas9(3.7)-BE3 |
| 108381 | xCas9(3.7)-BE4 | Mammalian expression vector for xCas9(3.7)-BE4 |
| 108382 | xCas9(3.7)-ABE(7.10) | Mammalian expression vector for xCas9(3.7)-ABE |
| 108383 | dxCas(3.7)-VPR | Mammalian expression vector for xCas9 3.7 with VP64-p65-Rta (VPR) fused to its C-terminus |
| 108384 | xCas9 3.6 | Mammalian expression vector for xCas9 3.6 |
| 108385 | xCas9(3.6)-BE3 | Mammalian expression vector for xCas9(3.6)-BE3 |
| 108386 | xCas9(3.6)-BE4 | Mammalian expression vector for xCas9(3.6)-BE4 |
| 108387 | xCas9(3.6)-ABE(7.10) | Mammalian expression vector for xCas9(3.6)-ABE |
| 108388 | dxCas(3.6)-VPR | Mammalian expression vector for xCas9 3.6 with VP64-p65-Rta (VPR) fused to its C-terminus |