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CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency.
Matharu N, Rattanasopha S, Tamura S, Maliskova L, Wang Y, Bernard A, Hardin A, Eckalbar WL, Vaisse C, Ahituv N Science. 2018 Dec 13. pii: science.aau0629. doi: 10.1126/science.aau0629.