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Directed evolution of adenine base editors with increased activity and therapeutic application.
Gaudelli NM, Lam DK, Rees HA, Sola-Esteves NM, Barrera LA, Born DA, Edwards A, Gehrke JM, Lee SJ, Liquori AJ, Murray R, Packer MS, Rinaldi C, Slaymaker IM, Yen J, Young LE, Ciaramella G
Nat Biotechnol. 2020 Apr 13. pii: 10.1038/s41587-020-0491-6. doi: 10.1038/s41587-020-0491-6.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
136294ABE8.8-mexpresses ABE8.8-m in mammalian cells
136295ABE8.8-dexpresses ABE8.8-d in mammalian cells
136296ABE8.13-mexpresses ABE8.13-m in mammalian cells
136297ABE8.13-dexpresses ABE8.13-d in mammalian cells
136298ABE8.17-mexpresses ABE8.17-m in mammalian cells
136299ABE8.17-dexpresses ABE8.17-d in mammalian cells
136300ABE8.20-m expresses ABE8.20-m in mammalian cells
136301ABE8.20-dexpresses ABE8.20-d in mammalian cells