Directed evolution of adenine base editors with increased activity and therapeutic application.
Gaudelli NM, Lam DK, Rees HA, Sola-Esteves NM, Barrera LA, Born DA, Edwards A, Gehrke JM, Lee SJ, Liquori AJ, Murray R, Packer MS, Rinaldi C, Slaymaker IM, Yen J, Young LE, Ciaramella G
Nat Biotechnol. 2020 Apr 13. pii: 10.1038/s41587-020-0491-6. doi: 10.1038/s41587-020-0491-6. PubMed Article
Gaudelli NM, Lam DK, Rees HA, Sola-Esteves NM, Barrera LA, Born DA, Edwards A, Gehrke JM, Lee SJ, Liquori AJ, Murray R, Packer MS, Rinaldi C, Slaymaker IM, Yen J, Young LE, Ciaramella G
Nat Biotechnol. 2020 Apr 13. pii: 10.1038/s41587-020-0491-6. doi: 10.1038/s41587-020-0491-6. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 136294 | ABE8.8-m | expresses ABE8.8-m in mammalian cells |
| 136295 | ABE8.8-d | expresses ABE8.8-d in mammalian cells |
| 136296 | ABE8.13-m | expresses ABE8.13-m in mammalian cells |
| 136297 | ABE8.13-d | expresses ABE8.13-d in mammalian cells |
| 136298 | ABE8.17-m | expresses ABE8.17-m in mammalian cells |
| 136299 | ABE8.17-d | expresses ABE8.17-d in mammalian cells |
| 136300 | ABE8.20-m | expresses ABE8.20-m in mammalian cells |
| 136301 | ABE8.20-d | expresses ABE8.20-d in mammalian cells |