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RNA isoform screens uncover the essentiality and tumor-suppressor activity of ultraconserved poison exons.
Thomas JD, Polaski JT, Feng Q, De Neef EJ, Hoppe ER, McSharry MV, Pangallo J, Gabel AM, Belleville AE, Watson J, Nkinsi NT, Berger AH, Bradley RK
Nat Genet. 2020 Jan;52(1):84-94. doi: 10.1038/s41588-019-0555-z. Epub 2020 Jan 7.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
138084Human CRISPR Poison Exon Knockout LibraryThe human pgPoison library induces skipping of “poison” cassette exons and corresponding upstream constitutive exons by targeting 3' splice sites with paired gRNAs (pgRNAs).