HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species.
Nicholson HE, Tariq Z, Housden BE, Jennings RB, Stransky LA, Perrimon N, Signoretti S, Kaelin WG Jr
Sci Signal. 2019 Oct 1;12(601). pii: 12/601/eaay0482. doi: 10.1126/scisignal.aay0482. PubMed Article
Nicholson HE, Tariq Z, Housden BE, Jennings RB, Stransky LA, Perrimon N, Signoretti S, Kaelin WG Jr
Sci Signal. 2019 Oct 1;12(601). pii: 12/601/eaay0482. doi: 10.1126/scisignal.aay0482. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 187638 | pLenti-EF1a-CDK6-mutPAM-PGK-puro | sg resistant CDK6 ORF |
| 187640 | pLX304-EV-IRES-GFP | Empty Vector control modified to express GFP |
| 187641 | pLX304-VHL-IRES-GFP | VHL Expression vector with GFP |
| 187642 | pLX304-VHLdeltaB-IRES-GFP | Mutant VHL Expression vector with GFP |
| 187643 | pLX304-VHL-IRES-Tdtomato | VHL Expression vector with Tdtomato |