APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia.
Sienski G, Narayan P, Bonner JM, Kory N, Boland S, Arczewska AA, Ralvenius WT, Akay L, Lockshin E, He L, Milo B, Graziosi A, Baru V, Lewis CA, Kellis M, Sabatini DM, Tsai LH, Lindquist S
Sci Transl Med. 2021 Mar 3;13(583). pii: 13/583/eaaz4564. doi: 10.1126/scitranslmed.aaz4564. PubMed Article
Sienski G, Narayan P, Bonner JM, Kory N, Boland S, Arczewska AA, Ralvenius WT, Akay L, Lockshin E, He L, Milo B, Graziosi A, Baru V, Lewis CA, Kellis M, Sabatini DM, Tsai LH, Lindquist S
Sci Transl Med. 2021 Mar 3;13(583). pii: 13/583/eaaz4564. doi: 10.1126/scitranslmed.aaz4564. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 160541 | pGS_101 | Expresses Human APOE4 with a yeast secretory signal peptide under the control of the yeast Gal promoter |
| 160650 | pGS_107 | Expresses Human APOE4 with a yeast secretory signal peptide under the control of the yeast Gal promoter |
| 160651 | pGS_128 | Expresses Human APOE3 with a yeast secretory signal peptide under the control of a beta-estradiol inducible promoter |
| 160652 | pGS_129 | Expresses Human APOE4 with a yeast secretory signal peptide under the control of a beta-estradiol inducible promoter |
| 160653 | pGS_591 | Expresses OLE1 under the control of the yeast Sup35 promoter |